Post-traumatic and post-surgical Absidia corymbifera infection in a young, healthy man

Mucormycoses caused byLichtheimiaspecies

“…These cases are generally associated with previous wounds or fractures due to traumatic accidents or surgery. Thus, contamination of wounds, either with plant material during accidents, or via non‐sterile bandages or surgical dressings, is the most likely route of infection . However, nosocomial infections due to person‐to‐person transmission also appear possible .…”

“…However, nosocomial infections due to person‐to‐person transmission also appear possible . Interestingly, trauma‐related infections have been described in patients without obvious underlying immunosuppression . Superficial infections can occur in patients suffering from an immunosuppressive disorder, such as leukaemia or HIV, but also in premature infants and apparently healthy adult persons .…”

Absidia Corymbiferain an immune competent accident victim with multiple abdominal injuries: case report

“…Posaconazole, which is also efficacious in vivo and in vitro [11], has been successfully administered in cases of amphotericin B intolerance [12], as salvage therapy for zygomycosis [13] and, in combination with amphotericin B, as therapy for disseminated infection [14]. Consequently, treatment of choice for A. corymbifera infection is early therapy with amphotocerin B alone or in combination with posaconazole, together with surgical asportation of necrotic tissue to remove the infected area [15]. As our patient had been affected by acute renal failure we opted for liposomal amphotercin B which ensured prolonged treatment at a sufficient dosage and no organ toxicity.…”

The Rise of an oppurtunistic infection called "Invasive zygomycosis"

“…Some of these predisposing conditions include: ketoacidosis and uncontrolled diabetes mellitus,[23] other forms of acidosis,[24] hematologic malignancies[14] or solid cancers,[25–27] immunosuppressive therapy even for a short period of time,[28–30] after solid organ[31–33] or following bone marrow transplantation,[34] patients with congenital or acquired neutropenia[35] or anemia such as thalassemia or aplastic anemia. [36–37] Individuals with acquired immunodeficiency syndrome (AIDS) are also prone to invasive phycomycosis among other fungal infections,[38–39] persons with history of intravenous drug abuse[40] or history of alcoholism;[41] it can be seen following trauma[42–43] or with different degrees of burns. [44–45] Hospital acquired zygomycosis can occur following invasive procedures such as central line catheter or pace-maker wire implantation[46–47] or frank surgical intervention.…”