Post-traumatic Headache: Pharmacologic Management and Targeting CGRP Signaling

Ashina, Håkan; Dodick, David W.

doi:10.1007/s11910-022-01175-w

Cited by 13 publications

(4 citation statements)

References 55 publications

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“…There seems to be an inverse relationship between the severity of head trauma and the occurrence of posttraumatic headaches. [ 28 , 29 ] Although the use of analgesics, such as ibuprofen, may be beneficial in the short-term, rebound headaches are common and can complicate treatment and recovery. [ 30 ] Therefore, their frequent use should be discouraged.…”

Section: Discussionmentioning

confidence: 99%

Research hotspots and trends on sports medicine of athletes: A scientometric analysis from 2003 to 2023

Tao,

2023

Medicine

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This study aims to demonstrate current research priorities and predict future trends of sports medicine of athletes by scientometric analysis. We collected nearly 20 years (2003 to 2023) of publications related to Sports medicine of athletes in the Web of Science database, Citespace was applied to evaluate the knowledge mapping. There are 4820 manuscripts about post-cesarean section in total, and faster growth after 2018. The country, institution, and author posted the most are the USA, Harvard University, and Engebretsen, Lars. Brit J Sport Med publishes the most articles of this type. In addition, the most key cited reference is Hopkins WG (2009). Sports medicine of athletes research, including blood, biomedical imaging informatics, and activity monitor has been a research hotspots in recent years. Through scientometric analysis of the past 20 years, we know the blood, biomedical imaging informatics, and activity monitor is the focus of future research. The USA, Australia, and England have become the main research forces in this field with high publication rates and centrality. This is important for accurately and quickly locating trends in this field.

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Section: Discussionmentioning

confidence: 99%

Research hotspots and trends on sports medicine of athletes: A scientometric analysis from 2003 to 2023

Tao,

2023

Medicine

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“…Western medicine can help improve headache symptoms to a certain extent. Simultaneously, the adverse effects of drugs and long-term medication can cause greater psychological stress in patients and serious disturbances in sleep quality [13–15] . Therefore, it is necessary to identify safe and effective treatments that have minimal adverse effects.…”

Section: Discussionmentioning

confidence: 99%

Effects of acupuncture treatment on posttraumatic headache after traumatic brain injury in patients

Yang

et al. 2022

Medicine

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Background:Posttraumatic headache (PTH) after traumatic brain injury (TBI) is a common clinical symptom, which refers to a headache that occurs after TBI. Acupuncture is often used for the treatment of such patients in China, and significant clinical effects have been achieved. However, to date, its efficacy has not been methodically evaluated. The purpose of this systematic review is to provide evidence to prove the effectiveness of acupuncture in the treatment of PTH in patients with TBI.Methods:This systematic review will be conducted in accordance with the preferred reporting items for systematic review and meta-analysis protocols. The following electronic databases will be searched from their inception to February 2022: PubMed, Web of Science, Embase, PsycINFO, the Cochrane Library, and Chinese databases such as Chinese Biomedical Literature (CBM), Chinese Medical Current Content (CMCC), Chinese Scientific Journal Database (VIP), WanFang Database, and China National Knowledge Infrastructure (CNKI). No language restrictions will be applied to the search strategy. Randomized controlled trials and cohort and case-control studies that met the inclusion and exclusion criteria will be included in this study. The meta-analysis will be performed using RevMan 5.3 software. Each session of this systematic review will be conducted independently by 2 members.Results:This review evaluates the efficacy of acupuncture in the treatment of PTH after TBI.Conclusion:This review provides substantial evidence for the clinical application of acupuncture in PTH treatment after TBI.Ethics and dissemination:Since the data in this study will be retrieved from published trials, therefore the Patient Consent Statement and Ethical Approval are not required. We will disseminate our results by publishing the research in a peer-reviewed journal.Trail registration number:The protocol was registered in INPLASY (INPLASY 202220073).

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“…Another study found that an intravenous infusion of CGRP triggers migraine-like headaches in people with PPCS, highlighting the significant role of CGRP in the genesis of post-traumatic headaches [122]. These connections suggest that targeting neuroinflammation early after concussion injuries may disrupt the cascade of events, potentially preventing PPCS development [123].…”

Section: Decreasing Neuroinflammationmentioning

confidence: 99%

Conservative Management of Acute Sports-Related Concussions: A Narrative Review

Kureshi,

Mendizabal,

Francis

et al. 2024

Healthcare

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This review explores the application of the conservative management model for pain to sports-related concussions (SRCs), framing concussions as a distinct form of pain syndrome with a pathophysiological foundation in central sensitization. Drawing parallels with proven pain management models, we underscore the significance of a proactive approach to concussion management. Recognizing concussions as a pain syndrome allows for the tailoring of interventions in alignment with conservative principles. This review first covers the epidemiology and controversies surrounding prolonged concussion recovery and persistent post-concussion symptoms (PPCS). Next, the pathophysiology of concussions is presented within the central sensitization framework, emphasizing the need for early intervention to mitigate the neuroplastic changes that lead to heightened pain sensitivity. Five components of the central sensitization process specific to concussion injuries are highlighted as targets for conservative interventions in the acute period: peripheral sensitization, cerebral metabolic dysfunction, neuroinflammation, glymphatic system dysfunction, and pain catastrophizing. These proactive interventions are emphasized as pivotal in accelerating concussion recovery and reducing the risk of prolonged symptoms and PPCS, in line with the philosophy of conservative management.

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Post-traumatic Headache: Pharmacologic Management and Targeting CGRP Signaling

Cited by 13 publications

References 55 publications

Research hotspots and trends on sports medicine of athletes: A scientometric analysis from 2003 to 2023

Research hotspots and trends on sports medicine of athletes: A scientometric analysis from 2003 to 2023

Effects of acupuncture treatment on posttraumatic headache after traumatic brain injury in patients

Conservative Management of Acute Sports-Related Concussions: A Narrative Review

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