Post-Traumatic Ocular Lymphoma in Three Rabbits (Oryctolagus Cuniculus)

Keller, Krista A.; Guzmán, David Sánchez-Migallón; Reilly, Christopher M.; Valentine, Beth A.; Boynton, Felicia D. Duke; Scott, Erin M.; Dubielzig, Richard R.

doi:10.1053/j.jepm.2018.02.041

Cited by 6 publications

(4 citation statements)

References 16 publications

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“…Although lymphoma seems to be a relatively common tumor in rabbits, only few studies 32,41 and some case reports or series are currently available. 22,24,29,45 According to von Lo ¨linger, 41 lymphoma was the most common tumor type in a population of laboratory and breeding rabbits, which were affected at 10 to 30 months of age. In the present study, however, lymphoma occurred in all age groups-including very young rabbits, in which other tumor types occurred rarely.…”

Section: Discussionmentioning

confidence: 99%

Neoplasia and Tumor-Like Lesions in Pet Rabbits (Oryctolagus cuniculus): A Retrospective Analysis of Cases Between 1995 and 2019

Bertram

Bartel

et al. 2020

Vet Pathol

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Prevalence and age distribution of tumors is largely unknown in pet rabbits. Currently available studies focused on specific organ systems or specific tumor types and never covered a comparative examination of all tumor types. Previous studies on laboratory rabbits suggested a low tumor prevalence but were mostly limited to young adult animals. In the present study, all tumor types and several tumor-like lesions of all organ systems were analyzed retrospectively in archived pet rabbit samples of all ages. Cases included necropsy cases ( n = 2,014) or postmortem tissue samples ( n = 102) as well as surgical biopsies ( n = 854). All lesions suspicious of neoplasia were reevaluated by histopathology and, when indicated, by immunohistochemistry. Necropsy cases had a tumor prevalence of 14.4% in both sexes or 19.8% in female intact rabbits of all age groups, and up to 47.2% or 66.7%, respectively, in rabbits older than 6 years. Overall, the most common tumor types were uterine adenocarcinoma (prevalence in female intact animals: 13.1%), lymphoma (prevalence: 2.8%), and thymoma (prevalence: 2.1%). Lymphoma, the most common tumor of rabbits ≤24 months of age, were of B-cell immunophenotype in 96% of cases and most commonly located in the lymph nodes (57%), gastrointestinal tract (54%), kidneys (48%), spleen (42%), and liver (41%). Tumors accounted for 81.1% of surgical biopsies and mostly comprised cutaneous, mammary, and uterine tumors. In conclusion, tumor types and prevalence varied significantly with respect to age, revealing some differences from previous studies on laboratory rabbits.

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Section: Discussionmentioning

confidence: 99%

Neoplasia and Tumor-Like Lesions in Pet Rabbits (Oryctolagus cuniculus): A Retrospective Analysis of Cases Between 1995 and 2019

Bertram

Bartel

et al. 2020

Vet Pathol

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“…68 B-cell lymphoma has also been observed in 3 rabbits following trauma. 51 Teratoma at the optic chiasm has been described. 52…”

Section: Nervous System and Sensory Organsmentioning

confidence: 99%

“…68 B-cell lymphoma has also been observed in 3 rabbits following trauma. 51 Teratoma at the optic chiasm has been described. 52 Malignant peripheral nerve sheath tumors apparently occur with some frequency, 99 but neoplasms of the central nervous system of rabbits are rarely reported.…”

Section: Nervous System and Sensory Organsmentioning

confidence: 99%

Not Just Uterine Adenocarcinoma—Neoplastic and Non-Neoplastic Masses in Domestic Pet Rabbits (Oryctolagus cuniculus): A Review

Baum

2021

Vet Pathol

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With increasing numbers of pet rabbits living out their natural lifespan, rabbit oncology is stepping more and more into the limelight. On the other hand, rabbit tumors are less covered in recent editions of textbooks of veterinary pathology than before. We present 1238 cases with neoplastic and non-neoplastic masses in rabbit tissue, submitted from 2008 to 2019, supplemented by a review of the literature on neoplasms in rabbits. Cutaneous masses comprised 47% of submissions. Trichoblastoma was by far the most common skin neoplasm, and nodular suppurative panniculitis was the second most frequent skin nodule in this series. Epithelial as well as mesenchymal cutaneous neoplasms can be virally induced in rabbits (eg, Shope papilloma, myxomatosis) but were infrequent in the current cases. Mammary neoplasms comprised 21% of submitted masses and 94% of these had histologic features of malignancy. Tumors of the female reproductive tract were responsible for 9% of biopsies and were predominantly uterine adenocarcinoma. Polypoid proliferation of rectal mucosa was the most common lesion in the alimentary tract. A broad spectrum of other neoplasms was described, including sarcomas at vaccination sites and ocular posttraumatic sarcomas, comparable to lesions described in cats.

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“…In the human medical literature, it is reported that inflammatory conditions including rheumatoid arthritis, coeliac disease and systemic lupus erythematosus are consistently associated with an increased risk of malignant lymphoma (Smedby et al., 2008). Other veterinary reports of lymphoma arising out of an inflammatory background include lymphoma and IBD in dogs and cats (Awaysheh et al., 2016), injection‐site sarcoma/lymphoma in cats (Roccabianca et al., 2016), post‐traumatic ocular lymphoma in rabbits (Keller et al., 2019). There are also reports of chronic inflammatory conditions suspected to contribute to oncogenesis in canine cases of chronic keratitis with corneal squamous cell carcinoma (Dreyfus et al., 2011).…”

Section: Discussionmentioning

confidence: 99%

The long‐term outcomes of standing superficial keratectomy as the sole treatment of corneal B‐cell lymphoma in five horses in the UK: Clinical, histopathology, immunohistochemical and molecular findings

De Oliveira,

Scurrell,

Dixon

et al. 2023

Equine Veterinary Education

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SummaryThis case report describes five horses with solitary corneal B‐cell lymphoma treated with superficial keratectomy as a sole treatment and their long‐term follow‐up. All five cases had a presumed clinical diagnosis of immune‐mediated keratitis (IMMK) which was initially responsive to immunosuppressive or immunomodulatory treatment. Between 6 and 71 months from the start of clinical disease, these cases became refractory to treatment. All five horses underwent superficial keratectomy under standing sedation and regional anaesthesia. A focal superficial keratectomy was performed in one horse to remove the affected area, and in the remaining four horses, the superficial cornea was removed in its entirety. Histopathology, immunohistochemistry (IHC) and polymerase chain reaction for antigen receptor rearrangements (PARR testing) were performed on all five keratectomy specimens. The histopathological and immunohistochemical findings indicated a florid stromal infiltrate of mitotically active, intermediate to large B‐lymphocytes amidst a variable background of chronic keratitis. In three of the five cases, the lymphocytes displayed prominent epitheliotropism. PARR testing confirmed rearrangements of, specifically, IGH2, IGH3 and KDE, indicating B‐cell clonal expansion consistent with B‐cell lymphoma. There has been no local recurrence in any of the five horses over 24–84 months of follow‐up and no clinical evidence of multicentric lymphoma. No adjunctive treatment was given post‐keratectomy and all eyes have remained comfortable and off treatment. Results of this report show that standing superficial keratectomy is a viable diagnostic tool and a long‐term treatment option for diffuse intermediate to large corneal B‐cell lymphoma.

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Post-Traumatic Ocular Lymphoma in Three Rabbits (Oryctolagus Cuniculus)

Cited by 6 publications

References 16 publications

Neoplasia and Tumor-Like Lesions in Pet Rabbits (Oryctolagus cuniculus): A Retrospective Analysis of Cases Between 1995 and 2019

Neoplasia and Tumor-Like Lesions in Pet Rabbits (Oryctolagus cuniculus): A Retrospective Analysis of Cases Between 1995 and 2019

Not Just Uterine Adenocarcinoma—Neoplastic and Non-Neoplastic Masses in Domestic Pet Rabbits (Oryctolagus cuniculus): A Review

The long‐term outcomes of standing superficial keratectomy as the sole treatment of corneal B‐cell lymphoma in five horses in the UK: Clinical, histopathology, immunohistochemical and molecular findings

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