Post-traumatic osteoarthritis: A review of pathogenic mechanisms and novel targets for mitigation

Dilley, Julian E.; Bello, Margaret Anne; Natoli, Roman M; McKinley, Todd O.; Sankar, Uma

doi:10.1016/j.bonr.2023.101658

Cited by 22 publications

(22 citation statements)

References 167 publications

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“…Intra-articular fracture, meniscal and ligamentous injury are common in modern combat trauma, particularly in the lower extremities. 12 , 45 The injury-related long-term aberrant loading to cartilage, subchondral bone, and synovium can cause osteoarthritis 46 which commonly presents with pain, reduced physical ability, and the potential for removal from active duty. 44 Chronic low back pain has also been associated with blast injury and other musculoskeletal injuries amongst military populations.…”

Section: Discussionmentioning

confidence: 99%

Pain after combat injury in male UK military personnel deployed to Afghanistan

Vollert,

Kumar,

Coady

et al. 2024

British Journal of Anaesthesia

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Section: Discussionmentioning

confidence: 99%

Pain after combat injury in male UK military personnel deployed to Afghanistan

Vollert,

Kumar,

Coady

et al. 2024

British Journal of Anaesthesia

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“…During the acute phase, trauma causes structural damage, hemarthrosis, and chondrocyte death, prompting an inflammatory response characterized by elevated levels of cytokines such as IL-1, IL-6, and tumour necrosis factor α (TNFα). These cytokines promote cartilage matrix degradation while inhibiting proteoglycan synthesis [ 6 - 8 ]. Subsequently, the chronic phase involves ongoing remodelling processes within the cartilage and other joint tissues, ultimately culminating in osteoarthritis.…”

Section: Reviewmentioning

confidence: 99%

A Comprehensive Review of Total Hip Arthroplasty Outcomes in Post-traumatic Hip Arthritis: Insights and Perspectives

Choudhary,

Pisulkar,

Taywade

et al. 2024

Cureus

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Post-traumatic hip arthritis presents a challenging condition characterized by degenerative changes in the hip joint following traumatic injury. Total hip arthroplasty (THA) is a cornerstone in managing this condition, offering significant pain relief, functional improvement, and enhanced quality of life. This comprehensive review aims to synthesize existing literature to elucidate the outcomes of THA in post-traumatic hip arthritis, exploring factors influencing surgical success and identifying areas for further research. Key findings reveal favourable clinical outcomes associated with THA, though considerations such as patient characteristics, surgical techniques, and implant selection impact outcomes. Implications for clinical practice underscore the importance of tailored preoperative assessment and ongoing advancements in surgical approaches and implant technology. Furthermore, opportunities for future research lie in long-term durability studies, patient-reported outcomes assessment, and exploration of innovative surgical techniques. Overall, THA emerges as a promising intervention for post-traumatic hip arthritis, yet continual refinement through research and innovation remains imperative to optimize patient care in this population.

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“…As with cytokines discussed in the section above, changes to interleukins with chiropractic care may have a simple biomechanical etiology: mechanical deformation to fascia and/or matrix may evoke the release of small molecule messengers [ 242 - 244 ]. Future studies should be conducted to confirm or refute the early observations discussed above and to more specifically elucidate the contribution of VS and the specific chiropractic adjustment to observed outcomes.…”

Section: Reviewmentioning

confidence: 99%

“…As with cytokines, interleukins, and IFNs discussed previously, changes to substance P with chiropractic care may have a simple biomechanical etiology [ 242 - 244 ] with both local and systemic effects possible. Future studies should be conducted to confirm or refute the early observations discussed within this section, and to more specifically elucidate the contribution of VS and the specific chiropractic adjustment to observed outcomes.…”

Section: Reviewmentioning

confidence: 99%

Vertebral Subluxation and Systems Biology: An Integrative Review Exploring the Salutogenic Influence of Chiropractic Care on the Neuroendocrine-Immune System

Haas,

Chung,

Kent

et al. 2024

Cureus

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In this paper we synthesize an expansive body of literature examining the multifaceted influence of chiropractic care on processes within and modulators of the neuroendocrine-immune (NEI) system, for the purpose of generating an inductive hypothesis regarding the potential impacts of chiropractic care on integrated physiology. Taking a broad, interdisciplinary, and integrative view of two decades of research-documented outcomes of chiropractic care, inclusive of reports ranging from systematic and meta-analysis and randomized and observational trials to case and cohort studies, this review encapsulates a rigorous analysis of research and suggests the appropriateness of a more integrative perspective on the impact of chiropractic care on systemic physiology. A novel perspective on the salutogenic, health-promoting effects of chiropractic adjustment is presented, focused on the improvement of physical indicators of well-being and adaptability such as blood pressure, heart rate variability, and sleep, potential benefits that may be facilitated through multiple neurologically mediated pathways. Our findings support the biological plausibility of complex benefits from chiropractic intervention that is not limited to simple neuromusculoskeletal outcomes and open new avenues for future research, specifically the exploration and mapping of the precise neural pathways and networks influenced by chiropractic adjustment.

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Post-traumatic osteoarthritis: A review of pathogenic mechanisms and novel targets for mitigation

Cited by 22 publications

References 167 publications

Pain after combat injury in male UK military personnel deployed to Afghanistan

Pain after combat injury in male UK military personnel deployed to Afghanistan

A Comprehensive Review of Total Hip Arthroplasty Outcomes in Post-traumatic Hip Arthritis: Insights and Perspectives

Vertebral Subluxation and Systems Biology: An Integrative Review Exploring the Salutogenic Influence of Chiropractic Care on the Neuroendocrine-Immune System

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