Post-traumatic stress disorder affects fucose-α(1–2)-glycans in the human brain: preliminary findings of neuro deregulation using in vivo two-dimensional neuro MR spectroscopy

Quadrelli, Scott; Tosh, Nathan; Urquhart, Aaron; Trickey, Katie; Tremewan, Rosanna; Galloway, Graham J.; Rich, Lisa; Lea, Rodney Arthur; Malycha, Peter; Mountford, Carolyn E.

doi:10.1038/s41398-018-0365-6

Cited by 9 publications

(15 citation statements)

References 32 publications

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“…The capacity to monitor fucose-α(1–2) glycans in vivo in the human brain is an essential step in evaluating how these alter with brain function and how this is altered with pain and/or mental health disorders 1,11 . In a cohort of patients with PTSD, the 2D L-COSY identified statistically significant increases in the total spectral region containing both free substrate fucose and fucosylated glycans 11 . This was the first evidence of fucosylated glycans, reported in animals to be involved in learning and memory, to be affected in humans with PTSD.…”

Section: Discussionmentioning

confidence: 99%

“…Statistically significant increases were reported in the spectral region containing crosspeaks from substrate fucose, as well as in the terminal fucose on the glycans, which showed a 31% increase compared to the healthy control cohort. There was a 48% and 41% increase in fucosylated glycan Fuc IV, and Fuc VI, respectively 11 .…”

Section: Introductionmentioning

confidence: 95%

“…Post-traumatic stress disorder (PTSD) has been shown to affect the fucose-α(1–2)-glycans in the human brain 11 using the 2D L-COSY protocol. Statistically significant increases were reported in the spectral region containing crosspeaks from substrate fucose, as well as in the terminal fucose on the glycans, which showed a 31% increase compared to the healthy control cohort.…”

Section: Introductionmentioning

confidence: 99%

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Two New Fucose-α (1–2)-Glycans Assigned In The Healthy Human Brain Taking The Number To Seven

Tosh

Quadrelli

Galloway

et al. 2019

Sci Rep

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Fucosylated glycans are involved in the molecular mechanisms that underpin neuronal development, learning and memory. The capacity to study the fucose-α(1–2)-glycan residues noninvasively in the human brain, is integral to understanding their function and deregulation. Five fucose crosspeaks were assigned to fucosylated glycans using in vivo two-dimensional magnetic resonance Correlated SpectroscopY (2D L-COSY) of the brain. Recent improvements encompassed on the 3T Prisma (Siemens, Erlangen) with a 64-channel head and neck coil have allowed two new assignments. These are Fuc VI (F2:4.44, F1:1.37 ppm) and Fuc VII (F2: 4.29, F1:1.36 ppm). The Fuc VI crosspeak, close to the water resonance, is resolved due to decreased T1 noise. Fuc VII crosspeak, located between Fuc I and III, is available for inspection due to increased spectral resolution. Spectra recorded from 33 healthy men and women showed a maximum variation of up to 0.02 ppm in chemical shifts for all crosspeaks.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

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Two New Fucose-α (1–2)-Glycans Assigned In The Healthy Human Brain Taking The Number To Seven

Tosh

Quadrelli

Galloway

et al. 2019

Sci Rep

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“…Only two published findings have been reported for glutathione (GSH), both increases, in dorsolateral prefrontal and anterior cingulate cortices. Studies of additional metabolites, such as sugars and lipids measurable by 2D J -resolved proton spectroscopy reported in Quadrelli et al, 79 have been limited. *PTSD versus control groups that included trauma-exposed and/or military veteran individuals.…”

Section: Resultsmentioning

confidence: 99%

Proton Magnetic Resonance Spectroscopy in Post-Traumatic Stress Disorder—Updated Systematic Review and Meta-Analysis

et al. 2022

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A stressor-related disorder wherein traumatic experience precipitates protracted disruptions to mood and cognition, post-traumatic stress disorder (PTSD) is associated with wide-ranging abnormalities across the body. While various methods have investigated these deviations, only proton magnetic resonance spectroscopy (1H MRS) enables noninvasive measurement of small-molecule metabolites in the living human. 1H MRS has correspondingly been employed to test hypotheses about the composition and function of multiple brain regions putatively involved in PTSD. Here we systematically review methodological considerations and reported findings, both positive and negative, of the current 1H-MRS literature in PTSD (N = 32 studies) to communicate the brain regional metabolite alterations heretofore observed, providing random-effects model meta-analyses for those most extensively studied. Our review suggests significant PTSD-associated decreases in N-acetyl aspartate in bilateral hippocampus and anterior cingulate cortex with less evident effect in other metabolites and regions. Model heterogeneities diverged widely by analysis (I2 < 0.01% to 90.1%) and suggested regional dependence on quantification reference (creatine or otherwise). While observed variabilities in methods and reported findings suggest that 1H-MRS explorations of PTSD could benefit from methodological standardization, informing this standardization by quantitative assessment of the existing literature is currently hampered by its small size and limited scope.

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“…Different patterns of tissue injury cause metabolic changes at the neuron level, which may be due to brain compression in line for space-occupying lesions, including brain tumors, abscess, and edema 4,5 . Such brain injuries cause the diverse patterns of metabolic variations in the brain measured by MRS and can be used to assess possible cause of disease, differentiating relative non-neoplastic and neoplastic brain lesions, as well as for the assessment of the prognostic factor for metastatic disease 6,7 .…”

Section: Introductionmentioning

confidence: 99%

Magnetic Resonance Spectroscopy: Role in clinical decision making and accurate diagnosis of the brain lesions

Kalhoro

Sattar

Hashim

et al. 2021

Int. j. endorsing health sci. res.

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Background: Magnetic Resonance Spectroscopy (MRS) combined Magnetic Resonance Spectroscopic Imaging (MRSI) can diagnose brain lesions and help manage several diseases. It has the advantage of differentiating neoplastic brain lesions from non-neoplastic brain lesions based on metabolic changes of the brain. The present study focuses on Magnetic Resonance Spectroscopy (MRS) assessment accuracy in the diagnosis of brain lesions. Methodology: A prospective, non-probability, consecutive sampling study was conducted at the Neurospinal & Cancer care institute, Karachi-Pakistan, from June 2017 to September 2020. A total of 161 patients with brain space-occupying lesions shown on MRI brain contrast and associated with clinical symptoms of headache, fits, or limb weakness was included in the study. The single voxel method was used for MRS; after contrast. MRI was used to localize the pathology in the brain, and the voxel was used in the area of heed interest. Results Spectroscopy interpretation showed that 114(70.8%) patients were diagnosed with a brain tumour, 41 (25.46%) had a non-neoplastic entity, and 6 (3.72%) were reported as non-specified. MR Spectroscopy reported non-neoplastic entities in 41 (25.46%) patients by spectroscopy. among them, 39(95.12%) patients had decreased choline, NAA and creatinine peaks, raised lactate peak 16(39.02%), lipid peaks 20(48.78%), while in 4 (9.75%) patients the peaks were absent. Conclusion: This study recommends that MR spectroscopy has a high accuracy for the diagnostic purpose of neoplastic and non-neoplastic, which is 91.33% which can affect the course of the treatment plan and it can help to avoid unnecessary delay in management.

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Post-traumatic stress disorder affects fucose-α(1–2)-glycans in the human brain: preliminary findings of neuro deregulation using in vivo two-dimensional neuro MR spectroscopy

Cited by 9 publications

References 32 publications

Two New Fucose-α (1–2)-Glycans Assigned In The Healthy Human Brain Taking The Number To Seven

Two New Fucose-α (1–2)-Glycans Assigned In The Healthy Human Brain Taking The Number To Seven

Proton Magnetic Resonance Spectroscopy in Post-Traumatic Stress Disorder—Updated Systematic Review and Meta-Analysis

Magnetic Resonance Spectroscopy: Role in clinical decision making and accurate diagnosis of the brain lesions

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