Post-traumatic stress disorder increases pain sensitivity by reducing descending noradrenergic and serotoninergic modulation

Vieira, Jádina S.; Souza, Guilherme Eduardo de; Kalil-Cutti, Bruna; Giusti‐Paiva, Alexandre; Vilela, Fabiana C.

doi:10.1016/j.bbr.2021.113367

Cited by 4 publications

(3 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this context, SIH is marked by higher levels of the phosphorylated extracellular signal-regulated kinase (pERK) along with higher levels of tryptophan hydroxylase (TPH) in the RVM serotonergic neurons, indicating an increase in the descending serotonergic neurotransmission [68]. On the contrary, a rodent model relevant to post-traumatic stress disorder presents SIH in addition to a decrease in serotonergic neurons in the dorsal raphe nucleus (DRN), which is not part of the RVM anatomical delimitation [69]. These results indicate that stress may have differential impacts on distinct populations of serotonergic neurons, potentially leading to different outcomes.…”

Section: Other Mechanisms Implicating the Rvm In Stress Responsementioning

confidence: 99%

The Role of The Rostral Ventromedial Medulla in Stress Responses

Pagliusi

Gomes

2023

Brain Sciences

View full text Add to dashboard Cite

The rostral ventromedial medulla (RVM) is a brainstem structure critical for the descending pain modulation system involved in both pain facilitation and inhibition through its projection to the spinal cord. Since the RVM is well connected with pain- and stress-engaged brain structures, such as the anterior cingulate cortex, nucleus accumbens, and amygdala, its involvement in stress responses has become a matter of great interest. While chronic stress has been proposed as a trigger of pain chronification and related psychiatric comorbidities due to maladaptive stress responses, acute stress triggers analgesia and other adaptative responses. Here we reviewed and highlighted the critical role of the RVM in stress responses, mainly in acute stress-induced analgesia (SIA) and chronic stress-induced hyperalgesia (SIH), providing insights into pain chronification processes and comorbidity between chronic pain and psychiatric disorders.

show abstract

Section: Other Mechanisms Implicating the Rvm In Stress Responsementioning

confidence: 99%

The Role of The Rostral Ventromedial Medulla in Stress Responses

Pagliusi

Gomes

2023

Brain Sciences

View full text Add to dashboard Cite

show abstract

“…The LC is also thought to be the target region of gabapentinoids in the treatment of neuropathic pain [143]. It has been implicated in many psychiatric and neurologic conditions, such as Parkinson's disease, post-traumatic stress disorder, anxiety, and insomnia, where arousal plays a seminal part [144][145][146][147].…”

Section: Central Sensitization the Brainstem Subcortex And Cerebral C...mentioning

confidence: 99%

From Low-Grade Inflammation in Osteoarthritis to Neuropsychiatric Sequelae: A Narrative Review

Naumovs

Groma

Mednieks

2022

IJMS

View full text Add to dashboard Cite

Nowadays, osteoarthritis (OA), a common, multifactorial musculoskeletal disease, is considered to have a low-grade inflammatory pathogenetic component. Lately, neuropsychiatric sequelae of the disease have gained recognition. However, a link between the peripheral inflammatory process of OA and the development of neuropsychiatric pathology is not completely understood. In this review, we provide a narrative that explores the development of neuropsychiatric disease in the presence of chronic peripheral low-grade inflammation with a focus on its signaling to the brain. We describe the development of a pro-inflammatory environment in the OA-affected joint. We discuss inflammation-signaling pathways that link the affected joint to the central nervous system, mainly using primary sensory afferents and blood circulation via circumventricular organs and cerebral endothelium. The review describes molecular and cellular changes in the brain, recognized in the presence of chronic peripheral inflammation. In addition, changes in the volume of gray matter and alterations of connectivity important for the assessment of the efficacy of treatment in OA are discussed in the given review. Finally, the narrative considers the importance of the use of neuropsychiatric diagnostic tools for a disease with an inflammatory component in the clinical setting.

show abstract

“…Serotonin is a monoamine neurotransmitter synthesized from tryptophan—an amino acid. Neurons that contain 5-HT are derived from the dorsal and medial raphe nuclei in the brainstem and target multiple areas of the forebrain, including the amygdala, the bed nucleus of the stria terminalis, the hippocampus, the hypothalamus and the prefrontal cortex [ 26 , 27 , 28 ]. 5-HT is responsible for regulating sleep, appetite, sexual behavior, aggression/impulsivity, motor function, analgesia and neuroendocrine function.…”

Section: Introductionmentioning

confidence: 99%

Changes in the Serum Concentration Levels of Serotonin, Tryptophan and Cortisol among Stress-Resilient and Stress-Susceptible Individuals after Experiencing Traumatic Stress

Ogłodek

2022

IJERPH

View full text Add to dashboard Cite

Background: Stress is a common response to many environmental adversities. However, once dysregulated, this reaction can lead to psychiatric illnesses, such as post-traumatic stress disorder (PTSD). Individuals can develop PTSD after exposure to traumatic events, severely affecting their quality of life. Nevertheless, not all individuals exposed to stress will develop psychiatric disorders, provided they show enhanced stress-resilience mechanisms that enable them to successfully adapt to stressful situations and thus avoid developing a persistent psychopathology. Methods: The study involved 93 participants. Of them, 62 comprised a study group and 31 comprised a control group. The aim of the study was to assess serotonin, cortisol and tryptophan concentration levels in subjects with PTSD (stress-susceptible; PTSD-SS) and in healthy individuals (stress-resilient; PTSD-SR), who had experienced a traumatic event but fully recovered after the trauma. The subjects were between 18 and 50 years of age (mean 35.56 ± 8.26 years). The serum concentration levels of serotonin, cortisol and tryptophan were measured with an ELISA kit. Results: It was found that the serotonin, tryptophan and cortisol concentration levels were consistent with the features of both PTSD-SR and PTSD-SS patients. It was reported that the mean cortisol concentration levels increased more significantly in the PTSD-SS group than in the PTSD-SR group, versus those in the control group. Similarly, the PTSD-SS group was found to show a larger decrease in the mean serotonin concentration levels than the PTSD-SR group, versus those in the control group. No significant changes were found in the tryptophan concentration levels between the study groups, versus those in the control group. Conclusions: These findings can be useful when attempting to improve resilience in individuals using neuropharmacological methods. However, it is necessary to conduct more cross-sectional studies that would address different types of negative stress to find out whether they share common pathways.

show abstract

Post-traumatic stress disorder increases pain sensitivity by reducing descending noradrenergic and serotoninergic modulation

Cited by 4 publications

References 36 publications

The Role of The Rostral Ventromedial Medulla in Stress Responses

The Role of The Rostral Ventromedial Medulla in Stress Responses

From Low-Grade Inflammation in Osteoarthritis to Neuropsychiatric Sequelae: A Narrative Review

Changes in the Serum Concentration Levels of Serotonin, Tryptophan and Cortisol among Stress-Resilient and Stress-Susceptible Individuals after Experiencing Traumatic Stress

Contact Info

Product

Resources

About