Post-traumatic stress disorder

Bisson, Jonathan I.; Cosgrove, Sarah J.; Lewis, Catrin; Roberts, Neil P.

doi:10.1136/bmj.h6161

Cited by 232 publications

(196 citation statements)

References 39 publications

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“…In the first days after exposure, symptoms of re-experiencing, avoidance and hyperarousal are relatively common. Usually, these symptoms decrease over time (Bisson, Cosgrove, Lewis, & Roberts, 2015); however, in approximately 9% of individuals, symptoms persevere and develop into posttraumatic stress disorder (PTSD; Breslau, 2009). Besides significantly compromising a person’s well-being and impairing psychosocial and occupational functioning (Olatunji, Cisler, & Tolin, 2007), PTSD also places a heavy burden on society (Olesen, Gustavsson, Svensson, Wittchen, & Jönsson, 2012).…”

Section: Introductionmentioning

confidence: 99%

Development and testing of TraumaGameplay: an iterative experimental approach using the trauma film paradigm

Asselbergs

Sijbrandij

Hoogendoorn³

et al. 2018

European Journal of Psychotraumatology

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Background: Vivid trauma-related intrusions are a hallmark symptom of posttraumatic stress disorder (PTSD), and may be involved in its onset. Effective interventions to reduce intrusions and to potentially prevent the onset of subsequent PTSD are scarce. Studies suggest that playing the videogame Tetris, shortly after watching aversive film clips, reduces subsequent intrusions. Other studies have shown that taxing working memory (WM) while retrieving an emotional memory reduces the memory’s vividness and emotionality. Objective: We developed TraumaGameplay (TGP), a gaming app designed to reduce intrusions. This paper describes two successive experiments to determine whether playing TGP without memory retrieval (regular TGP) or TGP with memory retrieval (dual-task TGP) reduces intrusion frequency at one week compared to a no-game control. Method: For both experiments, healthy university students were recruited. Experiment 1: 92 participants were exposed to a trauma film and randomized to (1) regular TGP1 (n = 31), (2) dual-task TGP1 (n = 31) or (3) control (n = 30). In experiment 2, 120 healthy students were exposed to a trauma film and randomized to (1) regular TGP2 (n = 30), (2) dual-task TGP2 (n = 29), (3) recall only (n = 31) or (4) control (n = 30). Results: We found no significant difference between conditions on the number of intrusions for either playing regular TGP or dual-task TGP in both experiment 1 and experiment 2. Conclusion: Our results could not replicate earlier promising findings from preceding experimental research. Several reasons may underpin this difference ranging from the visuospatial videogame used in our experiments to the method of the experiment to the difficulties of replicability in general.

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Section: Introductionmentioning

confidence: 99%

Development and testing of TraumaGameplay: an iterative experimental approach using the trauma film paradigm

Asselbergs

Sijbrandij

Hoogendoorn³

et al. 2018

European Journal of Psychotraumatology

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“…Our results further suggest that the attenuation of NOX2-induced excessive oxidative stress might play a key role in the neuro-protective effects of EE in this animal model. PTSD is a stress-based neuropsychiatric disorder that develops following the exposure to a traumatic event such as war, violence, rape or natural disaster [1,18] and involves diverse mechanisms. It is generally accepted that hypothalamo-pituitary-adrenal axis function is altered and cortisol levels are increased in PTSD patients [19].…”

Section: Discussionmentioning

confidence: 99%

“…Post-traumatic stress disorder (PTSD) is a complex psychiatric disorder characterized by the intrusive re-experiencing of past trauma, avoidant behavior, enhanced fear, and hyperarousal after a traumatic event in vulnerable individuals [1,2]. It has been suggested that PTSD is associated with an increased risk of suicide and remarkable deficits in social and occupational functioning [3].…”

Section: Introductionmentioning

confidence: 99%

Amelioration of oxidative stress-induced phenotype loss of parvalbumin interneurons might contribute to the beneficial effects of environmental enrichment in a rat model of post-traumatic stress disorder

Sun

Zhang

Zhao

et al. 2016

Behavioural Brain Research

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“…Occupational predilection to trauma places emergency service personnel at risk. Trauma-focused exposure-based therapy (EBT) is understood to improve PTSD symptoms 2. Contemporary research investigates the efficacy of ‘prolonged’ and ‘brief’ EBT within specific PTSD populations 3…”

Section: Contextmentioning

confidence: 99%

Exposure-based cognitive behavioural therapy is effective in reducing post-traumatic stress disorder severity in emergency service personnel

Kerin

2019

Evid Based Nurs

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Post-traumatic stress disorder

Cited by 232 publications

References 39 publications

Development and testing of TraumaGameplay: an iterative experimental approach using the trauma film paradigm

Development and testing of TraumaGameplay: an iterative experimental approach using the trauma film paradigm

Amelioration of oxidative stress-induced phenotype loss of parvalbumin interneurons might contribute to the beneficial effects of environmental enrichment in a rat model of post-traumatic stress disorder

Exposure-based cognitive behavioural therapy is effective in reducing post-traumatic stress disorder severity in emergency service personnel

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