Post-trial injection of atropine into the caudate nucleus interferes with long-term but not with short-term retention of passive avoidance

Prado-Alcalá, Roberto A.; Signoret-Edward, L.; Figueroa, M.; Giòrdano, Magda; Barrientos, Manuel Alejandro Fernández

doi:10.1016/s0163-1047(84)90460-6

Cited by 12 publications

(5 citation statements)

References 3 publications

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“…Our results indicate that such interpretation may be misleading, since they failed measure the conditioned response shortly after training, as was done in the present experiment. A similar outcome was found following cholinergic blockade of the striatum: good retention of one-trial IA was found 30 min after training, but significant retrograde amnesia occurred when retention was evaluated 24 h afterwards [18].…”

Section: Discussionsupporting

confidence: 69%

Effects of Lesions of Hippocampal Fields CA1 and CA3 on Acquisition of Inhibitory Avoidance

et al. 2002

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Performance decrements of inhibitory avoidance (IA) induced by lesions in either the dorsal or ventral hippocampus have been interpreted as a deficiency in acquisition. Alternative interpretations are that short-term learning occurs despite the lesions and the long-term performance decrements reflect a failure of consolidation or retrieval. To assess the alternative explanations of the performance decrements, rats received lesions in either CA1 or CA3 fields of dorsal and ventral hippocampus, respectively, 8 days before IA training. Retention was tested at 30 min or 24 h after training. Kainic acid lesions were also produced in either hippocampal field 1 day after training and retention measured 8 days later. The group assessed 30 min after IA training showed little or no performance decrements, whereas the remaining groups did show marked performance decrements. These results do not support the conclusion that the hippocampus is essential for acquisition and support the idea that the hippocampus is highly involved in the consolidation or retrieval of information germane to these procedures.

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Section: Discussionsupporting

confidence: 69%

Effects of Lesions of Hippocampal Fields CA1 and CA3 on Acquisition of Inhibitory Avoidance

et al. 2002

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“…The current finding that oxotremorine administered into the dorsal striatum after inhibitory avoidance training enhanced 48 h retention performance is consistent with extensive evidence from other studies indicating that post-training activation of muscarinic receptors in this brain region enhances retention of inhibitory avoidance training (Solana-Figueroa and Prado-Alcalá, 1990; Ortega et al, 1996; Packard et al, 1996) or of training on several other learning tasks (Brimblecombe, 1964; Baratti et al, 1979), whereas a post-training blockade of muscarinic receptors impairs retention of inhibitory avoidance and other training (Prado-Alcalá et al, 1984b; Giordano and Prado-Alcalá, 1986). Similarly, our finding that post-training infusions of corticosterone into the dorsal striatum enhance retention of inhibitory avoidance training is consistent with other recent findings from our laboratory (Medina et al, 2007).…”

Section: Discussionmentioning

confidence: 85%

“…On the one hand, it has been shown that striatal cholinergic interneurons are involved in motor control, as seen in humans where dysfunction of this complex system leads to movement disorders such as Huntington's and Parkinson's disease (Sandberg et al, 1984; Galarraga et al, 1999; Pisani et al, 2001; Wilson, 2004; Graybiel, 2008). On the other hand, muscarinic receptor antagonists administered into the dorsal striatum are known to induce retrograde amnesia of inhibitory avoidance training (Haycock et al, 1973; Prado-Alcalá et al, 1980) in a time- and dose-dependent fashion (Prado-Alcalá et al, 1984b, 1985; Giordano and Prado-Alcalá, 1986), whereas the intra-striatal administration of muscarinic receptor agonists improves retention of this training (Solana-Figueroa and Prado-Alcalá, 1990). Additional support for the view that the striatal cholinergic system modulates memory consolidation came from experiments indicating that local activation or blockade of the cholinergic system either enhances or impairs memory of active avoidance, lever pressing, and autoshaping (Neill and Grossman, 1970; Prado-Alcalá et al, 1984a; Bermúdez-Rattoni et al, 1986).…”

Section: Introductionmentioning

confidence: 99%

Glucocorticoid-cholinergic interactions in the dorsal striatum in memory consolidation of inhibitory avoidance training

Sánchez-Resendis

Medina

Serafín

et al. 2012

Front. Behav. Neurosci.

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Extensive evidence indicates that glucocorticoid hormones act in a variety of brain regions to enhance the consolidation of memory of emotionally motivated training experiences. We previously reported that corticosterone, the major glucocorticoid in the rat, administered into the dorsal striatum immediately after inhibitory avoidance training dose-dependently enhances memory consolidation of this training. There is also abundant evidence that the intrinsic cholinergic system of the dorsal striatum is importantly involved in memory consolidation of inhibitory avoidance training. However, it is presently unknown whether these two neuromodulatory systems interact within the dorsal striatum in the formation of long-term memory. To address this issue, we first investigated in male Wistar rats whether the muscarinic receptor agonist oxotremorine administered into the dorsal striatum immediately after inhibitory avoidance training enhances 48 h retention of the training. Subsequently, we examined whether an attenuation of glucocorticoid signaling by either a systemic administration of the corticosterone-synthesis inhibitor metyrapone or an intra-striatal infusion of the glucocorticoid receptor (GR) antagonist RU 38486 would block the memory enhancement induced by oxotremorine. Our findings indicate that oxotremorine dose-dependently enhanced 48 h retention latencies, but that the administration of either metyrapone or RU 38486 prevented the memory-enhancing effect of oxotremorine. In the last experiment, corticosterone was infused into the dorsal striatum together with the muscarinic receptor antagonist scopolamine immediately after inhibitory avoidance training. Scopolamine blocked the enhancing effect of corticosterone on 48 h retention performance. These findings indicate that there are mutual interactions between glucocorticoids and the striatal cholinergic system in enhancing the consolidation of memory of inhibitory avoidance training.

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“…Early studies from the mid-sixties to the late seventies used pretraining, irreversible lesion procedures to selectively destroy striatal nuclei and reveal their importance in avoidance learning, see for instance [161] and [180]. In the following years, Prado-Alcala and colleagues addressed the role of the striatal cholinergic system in the learning tasks [72,160,162,163,192]. Interestingly, blockade of muscarinic receptors with either scopolamine or atropine produced amnesia at 24 hours in passive avoidance, but not at 30 min, and only when administered within minutes after training, suggesting that cholinergic interneurons in the dorsal striatum may be necessary to stabilize the initial trace before consolidation.…”

Section: Rodent Models For Learning and Memorymentioning

confidence: 99%

Cellular Mechanisms of Striatum-Dependent Behavioral Plasticity and Drug Addiction

Fasano

Brambilla

2002

CMM

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The striatum has long been known to be involved in the control of motor behavior, since disruption of dopamine-mediated function in this brain structure is directly linked to Parkinson's disease and other disorders of movement. However, it is now accepted that both dorsal and ventral striatal nuclei are also essential for a variety of cognitive processes, which depend on reward-based stimulus-response learning. Since the neuroanatomical and neurochemical organization of dorsal and ventral striatum is only partially overlapping, it is likely that both common and nucleus-specific cellular and molecular events contribute to synaptic plasticity, learning and memory processes mediated by these cerebral structures. Alterations in cell signaling in the striatum may be particularly important in the response to both acute and chronic administration of drugs of abuse, resulting in maladaptive changes in the reward-based associative learning involved in addiction, withdrawal and relapse.

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Post-trial injection of atropine into the caudate nucleus interferes with long-term but not with short-term retention of passive avoidance

Cited by 12 publications

References 3 publications

Effects of Lesions of Hippocampal Fields CA1 and CA3 on Acquisition of Inhibitory Avoidance

Effects of Lesions of Hippocampal Fields CA1 and CA3 on Acquisition of Inhibitory Avoidance

Glucocorticoid-cholinergic interactions in the dorsal striatum in memory consolidation of inhibitory avoidance training

Cellular Mechanisms of Striatum-Dependent Behavioral Plasticity and Drug Addiction

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