Post-weaning food restriction reduces adipose cellularity

Bertrand, Helen A.; Masoro, Edward J.; Yu, BP

doi:10.1038/266062a0

Cited by 8 publications

(1 citation statement)

References 12 publications

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“…Similarly, research with rats has suggested that pre-weaning feed restriction reduces fat cell number and that this, in turn, may prevent obesity in the adult (Hirsch & Han, 1969;Hirsch & Knittle, 1970;Oscai et al 1972Oscai et al , 1974Bertrand & Masoro, 1977). However, since invariably these comparisons have been made between animals of the same age but of widely different body-weights both at infancy and adulthood, it is probable that these conclusions also may be misleading.…”

Section: Discussionmentioning

confidence: 99%

The influence of protein nutrition in early life on growth and development of the pig

Campbell

Dunkin

1983

Br J Nutr

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1.The effects of feeding either high-protein (HP) or low-protein (LP) diets between 1.8 and 15 kg live weight (LW) and a low-energy (LE) or high-energy (HE) intake subsequently on the cellularity of muscle and adipose tissue in pigs growing to 75 kg LW were investigated.2. The effects of the nutritional treatments on muscle tissue were assessed from the weight and DNA content of the rn. adductor. For adipose tissue the total DNA content and fat cell size of the subcutaneous adipose tissue contained in the left shoulder joint were determined. 3.Feeding the LP diets in early life reduced the weight and DNA content of the m. adductor ( P < 0.01) and increased fat cell size (P < 0.01) at 15 kg LW.4. Subsequent to 15 kg there was an almost linear increase in muscle DNA with increasing LW, and the difference between pigs from the initial protein treatments progressively diminished and was no longer apparent at 60 kg LW. 5.At 30 kg LW, pigs given the LP diets before 15 kg LW contained less DNA in the subcutaneous adipose tissue from the shoulder joint (P < 0.01) and had larger fat cells (P < 0.05) than pigs given the HP diets initially.However, adipose DNA and fat cell size increased with increasing LW and the differences resulting from the initial protein treatments progressively diminished. On the LE and HE treatments subsequent to 15 kg these differences were no longer evident at 45 and 60 kg respectively. 6.Pigs given the HE intake subsequent to 15 kg, contained less DNA in muscle tissue (P i 0.05) at 60 and 75 kg LW and had larger fat cells (P < 0.05) at 45, 60 and 75 kg LW, than pigs on the LE treatment.Previous research at this centre (Campbell & Dunkin, 1980) indicated that protein deprivation over the live weight (LW) range 1.8-6.5 kg adversely affected the hyperplastic development of porcine muscle and subcutaneous adipose tissue and that these effects were still evident at 45 kg LW. The results of Gilbreath & Trout (1973) also suggest that protein restriction in early life reduces muscle DNA. However, for the pig there is little information on the extent to which cellular hyperplasia contributes to the post-natal development of muscle or adipose tissue. Thus, it is difficult to assess whether the adverse effects of protein deprivation in early life on the cellular development of either tissue are likely to be permanent or only transitory.The experiment reported by Campbell & Dunkin (1983) provided the opportunity to investigate the effects of protein nutrition between 1.8 and 15 kg LW and subsequent energy intake on the cellularity of muscle and subcutaneous adipose tissue of pigs grown to 75 kg LW. Because pigs were killed at LW intervals of 15 kg between 15 and 75 kg, the experiment also provided information on the progressive changes in the cellularity of both tissues with increase in LW. EXPERIMENTAL GeneralForty-two entire male piglets (Large White) were removed from their dams between 24 and 36 h after birth and as their individual LW reached 1.8 kg were randomly allocated to either

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Section: Discussionmentioning

confidence: 99%