Post-weaning social isolation increases ΔFosB/FosB protein expression in sex-specific patterns in the prelimbic/infralimbic cortex and hippocampus in mice

Noback, Michael; Zhang, Gongliang; White, Nia A.; Barrow, James C.; Carr, Gregory V.

doi:10.1016/j.neulet.2020.135423

Cited by 9 publications

(8 citation statements)

References 33 publications

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“…Older women are also more likely to be socially isolated based on census data demonstrating that, compared to men, women live alone more frequently [ 34 ]. In addition to higher risk for exposure to social isolation and loneliness in women, animal models suggest long-standing sex-dependent effects on abnormal gene expression in the brain related to neurological dysfunction [ 74 , 88 , 89 ].…”

Section: Discussionmentioning

confidence: 99%

The Long-Term Public Health Impact of Social Distancing on Brain Health: Topical Review

Kumar

Salinas

2021

IJERPH

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Social distancing has been a critical public health measure for the COVID-19 pandemic, yet a long history of research strongly suggests that loneliness and social isolation play a major role in several cognitive health issues. What is the true severity and extent of risks involved and what are potential approaches to balance these competing risks? This review aimed to summarize the neurological context of social isolation and loneliness in population health and the long-term effects of social distancing as it relates to neurocognitive aging, health, and Alzheimer’s disease and related dementias. The full scope of the underlying causal mechanisms of social isolation and loneliness in humans remains unclear partly because its study is not amenable to randomized controlled trials; however, there are many detailed experimental and observational studies that may provide a hypothesis-generating theoretical framework to better understand the pathophysiology and underlying neurobiology. To address these challenges and inform future studies, we conducted a topical review of extant literature investigating associations of social isolation and loneliness with relevant biological, cognitive, and psychosocial outcomes, and provide recommendations on how to approach the need to fill key knowledge gaps in this important area of research.

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Section: Discussionmentioning

confidence: 99%

The Long-Term Public Health Impact of Social Distancing on Brain Health: Topical Review

Kumar

Salinas

2021

IJERPH

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“…One of the largest remaining questions about the SI phenotype is how an organism translates the experience of SI stress to the observed behavioral effects. A previous study from our group [15] focused on the molecular effects of adolescent SI and found that the transcription factor ΔFosB was upregulated in SI males. Those findings about ΔFosB combined with the behavioral effects in this study are new pieces of the potential biological pathway between SI stress and the observed changes.…”

Section: Behavior Effects In the Greater Context Of Adolescent Si Effectsmentioning

confidence: 99%

“…Interestingly, postnatal days 21-35 is a period of significant amounts of social play behavior in mice and isolation during this period can lead to deficits in social interactions in adulthood [13,14]. Moreover, the social behavior deficits are directly related to abnormal interneuron function in the prefrontal cortex [14] We previously reported that SI during the 21-35 day period is associated with increased levels of ΔFosB, a transcription factor associated with chronic stress [15]. ΔFosB has also been implicated in studies of reward-seeking behavior [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Post-weaning social isolation increases reward-seeking behavior in a sex-specific manner in mice

Noback

Barrow

Carr

2021

Preprint

Self Cite

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Social isolation is a growing concern in public health. Although isolation at any age is harmful, previous studies have shown that isolation during adolescence, correlating with critical periods of brain development, can impair cognitive function and increase the risk for psychiatric illness later in life. In this study, we utilized a mouse model of adolescent social isolation (SI) and compared performance of isolated and group-housed mice on a touchscreen-based continuous performance test (CPT) and fixed ratio/progressive ratio (FR/PR) tasks in adulthood. SI increased sensitivity in the CPT in male mice and had no effect in female mice. The increase in sensitivity was consistent across time bins within the 45-minute testing session and there were no SI effects on reaction times or reward retrieval latencies. A possible confound for performance in the CPT would be SI-induced changes in reward-seeking or motivation for the strawberry milk reward. We next compared the SI mice to their group-housed littermate controls on both FR and PR schedules of reinforcement and found that male SI mice earned significantly more reinforcers on FR schedules of reinforcement and had higher breakpoints on PR schedules compared to their group-housed littermates. These data indicate that SI during adolescence has striking, sex-specific effects on reward-seeking behavior in adult mice and may provide a useful behavioral model for studying the link between SI and risk for neuropsychiatric disorders.

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“…Social isolation-induced stress impacts behavior. Prolonged social isolation in adulthood enhances the motivational value and anticipatory behaviors of a social encounter 10 , increases social interactions 11 , and impairs social memory 12 , 13 . Adult isolation can impair novel object recognition, induce territorial behaviors, and alter anxiety-like and risk assessment behavior in the open field 14 .…”

Section: Introductionmentioning

confidence: 99%

Combined space stressors induce independent behavioral deficits predicted by early peripheral blood monocytes

Rienecker

Grue

Paladini

et al. 2023

Sci Rep

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Interplanetary space travel poses many hazards to the human body. To protect astronaut health and performance on critical missions, there is first a need to understand the effects of deep space hazards, including ionizing radiation, confinement, and altered gravity. Previous studies of rodents exposed to a single such stressor document significant deficits, but our study is the first to investigate possible cumulative and synergistic impacts of simultaneous ionizing radiation, confinement, and altered gravity on behavior and cognition. Our cohort was divided between 6-month-old female and male mice in group, social isolation, or hindlimb unloading housing, exposed to 0 or 50 cGy of 5 ion simplified simulated galactic cosmic radiation (GCRsim). We report interactions and independent effects of GCRsim exposure and housing conditions on behavioral and cognitive performance. Exposure to GCRsim drove changes in immune cell populations in peripheral blood collected early after irradiation, while housing conditions drove changes in blood collected at a later point. Female mice were largely resilient to deficits observed in male mice. Finally, we used principal component analysis to represent total deficits as principal component scores, which were predicted by general linear models using GCR exposure, housing condition, and early blood biomarkers.

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Post-weaning social isolation increases ΔFosB/FosB protein expression in sex-specific patterns in the prelimbic/infralimbic cortex and hippocampus in mice

Cited by 9 publications

References 33 publications

The Long-Term Public Health Impact of Social Distancing on Brain Health: Topical Review

The Long-Term Public Health Impact of Social Distancing on Brain Health: Topical Review

Post-weaning social isolation increases reward-seeking behavior in a sex-specific manner in mice

Combined space stressors induce independent behavioral deficits predicted by early peripheral blood monocytes

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