Postal survey of ovine caseous lymphadenitis in the United Kingdom between 1990 and 1999

Binns, S. H.; Green, Laura; Bailey, Mick

doi:10.1136/vr.150.9.263

Cited by 26 publications

(17 citation statements)

References 9 publications

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“…Similar levels have been reported from the Canadian province of Quebec, with a prevalence of 21 to 36% [10]. In the United Kingdom, 45% of the producers that were polled reported abscesses in their sheep [9].…”

Section: Introductionsupporting

confidence: 76%

Evidence for Reductive Genome Evolution and Lateral Acquisition of Virulence Functions in Two Corynebacterium pseudotuberculosis Strains

et al. 2011

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Background Corynebacterium pseudotuberculosis, a Gram-positive, facultative intracellular pathogen, is the etiologic agent of the disease known as caseous lymphadenitis (CL). CL mainly affects small ruminants, such as goats and sheep; it also causes infections in humans, though rarely. This species is distributed worldwide, but it has the most serious economic impact in Oceania, Africa and South America. Although C. pseudotuberculosis causes major health and productivity problems for livestock, little is known about the molecular basis of its pathogenicity.Methodology and FindingsWe characterized two C. pseudotuberculosis genomes (Cp1002, isolated from goats; and CpC231, isolated from sheep). Analysis of the predicted genomes showed high similarity in genomic architecture, gene content and genetic order. When C. pseudotuberculosis was compared with other Corynebacterium species, it became evident that this pathogenic species has lost numerous genes, resulting in one of the smallest genomes in the genus. Other differences that could be part of the adaptation to pathogenicity include a lower GC content, of about 52%, and a reduced gene repertoire. The C. pseudotuberculosis genome also includes seven putative pathogenicity islands, which contain several classical virulence factors, including genes for fimbrial subunits, adhesion factors, iron uptake and secreted toxins. Additionally, all of the virulence factors in the islands have characteristics that indicate horizontal transfer.ConclusionsThese particular genome characteristics of C. pseudotuberculosis, as well as its acquired virulence factors in pathogenicity islands, provide evidence of its lifestyle and of the pathogenicity pathways used by this pathogen in the infection process. All genomes cited in this study are available in the NCBI Genbank database (http://www.ncbi.nlm.nih.gov/genbank/) under accession numbers CP001809 and CP001829.

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Section: Introductionsupporting

confidence: 76%

Evidence for Reductive Genome Evolution and Lateral Acquisition of Virulence Functions in Two Corynebacterium pseudotuberculosis Strains

et al. 2011

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“…Among flocks surveyed in Australia, the average prevalence of CLA in adult sheep was 26% (Paton et al, 2003). Forty-five percent of the farmers interviewed in a study in the United Kingdom had seen abscesses in their sheep; however, this could be an overestimation of CLA prevalence since few farmers had investigated the causes of the abscesses (Binns et al, 2002). Twenty-one percent of 485 culled sheep examined in Canadian slaughterhouses had CLA (Arsenault et al, 2003).…”

Section: Zeru and Kahsay 169mentioning

confidence: 97%

Caseous lymphadenitis in goats from Borena Range Land South Ethiopia slaughtered at Luna Export Abattoir

Zeru¹,

Kahsay²

2014

J. Vet. Med. Anim. Health

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to estimate the prevalence of caseous lymphadenitis (CLA) in goats. Detail post mortem examination and bacteriology were applied to undertake this study. On the bases of post mortem and bacteriological results, the prevalence of caseous lymphadenitis was 15% (60/400), out of which 42 (70%), 13 (21.7%) and 5 (8.3%) were cutaneous form, visceral form and generalized form, respectively. There is statistical significance difference (P < 0.05) among the three age groups. The study revealed that as age increases the prevalence also increases. Statistical significant difference was also recorded between goats having poor and good body condition score (P < 0.05). Moreover, goats with poor body condition score seem to be more infected (24.7%) than those goats with good body condition (12.5%). In conclusion, this study has indicated the occurrence of CLA in high frequency in goats of Borena range land. Therefore, further extensive research should be conducted over all the country to determine prevalence and economic significance of the disease.

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“…Recent epidemiological surveys have examined the prevalence of CLA in different countries [2,3,6,11,28,85]. Among flocks surveyed in Australia, the average prevalence of CLA in adult sheep was 26% [85].…”

Section: Epidemiology Of Clamentioning

confidence: 99%

“…Among flocks surveyed in Australia, the average prevalence of CLA in adult sheep was 26% [85]. Forty-five percent of the farmers interviewed in a study in the United Kingdom had seen abscesses in their sheep; however, this could be an overestimation of CLA prevalence since few farmers had investigated the causes of the abscesses [11]. Twenty-one percent of 485 culled sheep examined in Canadian slaughterhouses had CLA [3].…”

Section: Epidemiology Of Clamentioning

confidence: 99%

Corynebacterium pseudotuberculosis: microbiology, biochemical properties, pathogenesis and molecular studies of virulence

et al. 2006

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-Corynebacterium pseudotuberculosis is the etiological agent of caseous lymphadenitis (CLA), a common disease in small ruminant populations throughout the world. Once established, this disease is difficult to eradicate because drug therapy is not effective and because the clinical detection of infected animals is of limited efficiency. We reviewed the microbiological, biochemical and taxonomic features of C. pseudotuberculosis, general aspects of infection, the main virulence determinants and currently available commercial vaccines. We also examined the current molecular strategies for the study of virulence in C. pseudotuberculosis, including the latest research on the identification of novel virulence factors and genes, which will help us to better understand the biology of this microorganism. This knowledge may also contribute to the development of improved CLA vaccines, including subunit and DNA-based types, as well as to improve the diagnosis, treatment and control of this disease.

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Postal survey of ovine caseous lymphadenitis in the United Kingdom between 1990 and 1999

Cited by 26 publications

References 9 publications

Evidence for Reductive Genome Evolution and Lateral Acquisition of Virulence Functions in Two Corynebacterium pseudotuberculosis Strains

Evidence for Reductive Genome Evolution and Lateral Acquisition of Virulence Functions in Two Corynebacterium pseudotuberculosis Strains

Caseous lymphadenitis in goats from Borena Range Land South Ethiopia slaughtered at Luna Export Abattoir

Corynebacterium pseudotuberculosis: microbiology, biochemical properties, pathogenesis and molecular studies of virulence

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