Postanesthetic hyperthermia in cats: a retrospective comparison between hydromorphone and buprenorphine

Niedfeldt, Rebecca L; Robertson, Sheilah A.

doi:10.1111/j.1467-2995.2005.00275.x

Cited by 82 publications

(50 citation statements)

References 32 publications

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“…Skin temperature increased in cats in a manner dependent on the plasma oxymorphone concentration. While body temperature was not measured in the present study, opioid‐induced hyperthermia has been reported in cats (Niedfeldt & Robertson, 2006; Posner et al. , 2007, 2010).…”

Section: Discussionmentioning

confidence: 75%

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Effect of amantadine on oxymorphone‐induced thermal antinociception in cats

Siao

Pypendop

Escobar

et al. 2011

Vet Pharm & Therapeutics

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This study examined the effect of amantadine, an N-methyl-d-aspartate receptor antagonist, on the thermal antinociceptive effect of oxymorphone in cats. Six adult healthy cats were used. After baseline thermal threshold determinations, oxymorphone was administered intravenously to maintain plasma oxymorphone concentrations of 10, 20, 50, 100, 200, and 400 ng/mL. In addition, amantadine, or an equivalent volume of saline, was administered intravenously to maintain a plasma amantadine concentration of 1100 ng/mL. Thermal threshold and plasma oxymorphone and amantadine concentrations were determined at each target plasma oxymorphone concentration. Effect maximum models were fitted to the oxymorphone concentration-thermal threshold data, after transformation in % maximum response. Oxymorphone increased skin temperature, thermal threshold, and thermal excursion (i.e., the difference between thermal threshold and skin temperature) in a concentration-dependent manner. No significant difference was found between the amantadine and saline treatments. Mean ± SE oxymorphone EC(50) were 14.2 ± 1.2 and 24.2 ± 7.4 ng/mL in the amantadine and saline groups, respectively. These values were not significantly different. Large differences in oxymorphone EC(50) in the saline and amantadine treatment groups were observed in two cats. These results suggest that amantadine may decrease the antinociceptive dose of oxymorphone in some, but not all, cats.

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Section: Discussionmentioning

confidence: 75%

“…In addition, opioids also cause hyperthermia and sympathetic nervous system stimulation, particularly when high doses are used (Pascoe et al. , 1997; Niedfeldt & Robertson, 2006; Posner et al. , 2007, 2010).…”

Section: Introductionmentioning

confidence: 99%

Effect of amantadine on oxymorphone‐induced thermal antinociception in cats

Siao

Pypendop

Escobar

et al. 2011

Vet Pharm & Therapeutics

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“…In contrast to hydromorphone, buprenorphine has not been associated with hyperthermia (Wegner et al. 2004; Niedfeldt & Robertson, In press). The disposition of buprenorphine (10 μ g/kg) after intravenous (i.v.)…”

Section: Introductionmentioning

confidence: 99%

PK‐PD modeling of buprenorphine in cats: intravenous and oral transmucosal administration¹

Robertson

Lascelles

Taylor

et al. 2005

Vet Pharm & Therapeutics

180

283

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The pharmacokinetics and thermal antinociceptive effects of buprenorphine after intravenous (i.v.) or oral transmucosal (OTM) administration were studied in six adult cats. Plasma buprenorphine concentrations were measured using radioimmunoassay in a crossover study after a dose of 20 microg/kg given by the i.v. or OTM route. Oral pH was measured. Blood for drug analyses was collected before, and at 1, 2, 4, 6, 10, 15, 30, and 60 min and at 2, 4, 6, 8, 12, and 24 h after treatment. Thermal thresholds were measured before treatment, then following treatment every 30 min to 6 h, every 1 hour to 12 h and at 24 hours postadministration. Plasma buprenorphine concentration effect relationships were analyzed using a log-linear effect model. Oral pH was 9 in each cat. Peak plasma buprenorphine concentration was lower and occurred later in the OTM group but median bioavailability was 116.3%. Thermal thresholds increased significantly between 30 and 360 min in both groups. Peak effect was at 90 min and there was no difference at any time between the two groups. There was distinct hysteresis between plasma drug concentration and effect in both groups. Overall, OTM administration of buprenorphine is as effective as i.v. treatment and offers a simple, noninvasive method of administration which produces thermal antinociception for up to 6 h in cats.

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“…The literature suggests that cats have classically experienced more of the sigma effects of morphine (Table 7). 16 Significant hyperthermia may be treated with reversal of the opioid. lower doses.…”

Section: Opiodsmentioning

confidence: 99%

Pathophysiology and Management of Surgical and Chronic Oral Pain in Dogs and Cats

Beckman¹

2006

J Vet Dent

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Pain involves a myriad of physiochemical responses leading to the perception of an unpleasant sensation arising from tissue damage. An understanding of the terminology and basic neurophysiology involved with the pain process is helpful in preventing and treating discomfort in our patients. A general understanding of the concepts of nociception, peripheral sensitization, and central sensitization will allow decisions to be made on the choices of analgesic agents in each individual patient based upon the type, duration, and severity of the pain. Using preemptive pain management with a multimodal approach provides the most consistent and predictable results. Analgesic protocols should be closely scrutinized on an individual basis with careful patient pain assessment during the postoperative period. Chronic pain mechanisms, particularly significant in cancer pain and stomatitis, require aggressive and perhaps unique approaches to ensure maximum patient comfort. NociceptionNociception is defined as the processing of a noxious stimulus resulting in the perception of pain by the brain (Fig. 1). 1 The components of nociception include transduction, transmission, and modulation. 2 Transduction is the conversion of a noxious stimulus (mechanical, chemical, or thermal) into electrical energy by a peripheral nociceptor (free afferent nerve ending). Transmission involves impulse propagation from the site of oral injury primarily through the trigeminal afferent nerves.Nerve fibers involved include A-delta (fast) fibers responsible for the initial sharp pain, C (slow) fibers that cause the secondary dull, throbbing pain, and, A-beta (tactile) fibers that have a lower threshold of stimulation. Modulation in the oral cavity occurs when neurons from these fibers synapse with nociceptive-specific and wide dynamic range neurons in the nucleus caudalis located in the medulla. 3 This brain tissue is very similar to that of the spinal cord dorsal horn that modulates pain from areas other than the oral cavity. 3 Located within the excitatory synapse, neuropeptides such as glutamate and substance P facilitate the pain signals by binding to their receptors on these neurons. 2 At the same time, endogenous (opioid, serotonergic, and noradrenergic) descending analgesic systems serve to dampen the nociceptive response. 2 Peripheral SensitizationSurgical manipulation of tissues within the oral cavity results in a greatly enhanced nociceptor response to any additional stimulus postoperatively. This enhanced response is termed peripheral sensitization (hyperalgesia). 4 Primary hyperalgesia occurs when peripheral hyperalgesia develops at the site of injury. ATP, potassium ions, hydrogen ions, prostaglandins, bradykinin, and nerve growth factors are all released by the damaged tissue FOUNDATIONS

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Postanesthetic hyperthermia in cats: a retrospective comparison between hydromorphone and buprenorphine

Cited by 82 publications

References 32 publications

Effect of amantadine on oxymorphone‐induced thermal antinociception in cats

Effect of amantadine on oxymorphone‐induced thermal antinociception in cats

PK‐PD modeling of buprenorphine in cats: intravenous and oral transmucosal administration¹

Pathophysiology and Management of Surgical and Chronic Oral Pain in Dogs and Cats

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Postanesthetic hyperthermia in cats: a retrospective comparison between hydromorphone and buprenorphine

Cited by 82 publications

References 32 publications

Effect of amantadine on oxymorphone‐induced thermal antinociception in cats

Effect of amantadine on oxymorphone‐induced thermal antinociception in cats

PK‐PD modeling of buprenorphine in cats: intravenous and oral transmucosal administration1

Pathophysiology and Management of Surgical and Chronic Oral Pain in Dogs and Cats

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Product

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PK‐PD modeling of buprenorphine in cats: intravenous and oral transmucosal administration¹