Postantibiotic Effect, and Postantibiotic Effect of Subinhibitory Concentrations, of Sparfloxacin on Gram-Negative Bacteria

Odenholt-Tornqvist, Inga; Bengtsson, Stellan

doi:10.1159/000239167

Cited by 23 publications

(12 citation statements)

References 18 publications

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“…A number of in vitro studies have quantified the PAE induced by numerous antibiotics in a variety of Gram-positive 10,19,20,21,23,30 and Gram-negative bacteria 19,20,21,32 .…”

Section: Discussionmentioning

confidence: 99%

Cell surface hydrophobicity and adherence of a strain of group B streptococci during the post-antibiotic effect of penicillin

Araújo¹,

Oliveira²,

Mattos³

et al. 2008

Rev. Inst. Med. trop. S. Paulo

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SUMMARYThe minimum inhibitory concentration and post-antibiotic effects of an antimicrobial agent are parameters to be taken into consideration when determining its dosage schedules. The in vitro post-antibiotic effects on cell surface hydrophobicity and bacterial adherence were examined in one strain of group B streptococci. Exposure of the microorganism for 2 h at 37 °C to 1 x MIC of penicillin induced a PAE of 1.1 h. The cell surface charge of the Streptococcus was altered significantly during the postantibiotic phase as shown by its ability to bind to xylene: hydrophobicity was decreased. Bacterial adherence to human buccal epithelial cells was also reduced. The results of the present investigation indicate that studies designed to determine therapeutic regimens should evaluate the clinical significance of aspects of bacterial physiology during the post-antibiotic period.

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“…A number of in vitro studies have quantified the PAE induced by numerous antibiotics in a variety of Gram-positive 10,19,20,21,23,30 and Gram-negative bacteria 19,20,21,32 .…”

Section: Discussionmentioning

confidence: 99%

Cell surface hydrophobicity and adherence of a strain of group B streptococci during the post-antibiotic effect of penicillin

Araújo¹,

Oliveira²,

Mattos³

et al. 2008

Rev. Inst. Med. trop. S. Paulo

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“…The PAEs of different quinolones have also been confirmed by different authors (1, 12-14, 18, 19), but the duration was always shorter than those observed if aminoglycosides were used. Odenholt-Tornquist & Bengtsson (12) checked the PAEs of sparfloxacin against different Gram-negative clinical isolates by using the drug at 1OX MIC concentration. The PAE found was 1 h against P. aeruginosa isolates (12).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of post‐antibiotic effects of antipseudomonal antibiotics using an automated system

Mayer

Nagy

2000

APMIS

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Different methods have been described for determination of the post-antibiotic effects (PAEs) of antibiotics, from the conventional methods to the automatic measurement of bacterial regrowth. The PAEs of ciprofloxacin, ofloxacin and perfloxacin, as compared with those of amikacin, netilmicin and ceftazidime, have now been investigated for three clinical isolates of Pseudomonas species, using automated measurement of the growth with an Anthos microplate reader. It was found that, besides the well-known PAEs of aminoglycosides, quinolone antibiotics also exhibit drug- and concentration-dependent PAEs against clinical isolates of Pseudomonas when used in concentrations of 1/2x, 1 x or 5 x MIC. Of the three quinolones tested, pefloxacin showed the greatest PAE, independently of its MICs against the different strains. Ofloxacin had no or only an insignificant PAE, while ciprofloxacin had a marked PAE for all strains, including the reference strains.

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“…When we use antibiotics with a long half-life, such as 4-fluoroquinolones, part of the delay attributed to the PAE could be due to this action of residual concentrations in the tissue [4], Great in vitro bactericidal actions of the three antibiotics against the two microorgan isms have been observed (table 2). There are several studies on quinolones: sparfloxacin [31,32], that induced long PA-SEs but small SEs against Staphylococcus pyogenes and gram-negative bacteria, and with ciprofloxa cin, Zhanel et al [33] have studied the PAE and the SE of 1/2, 1/4 and 1/8 x MIC against Pseudomonas aeruginosa, and they found that they produced a growth inhibition for several hours.…”

Section: Discussionmentioning

confidence: 99%

Pharmacodynamic Effects of Ciprofloxacin, Fleroxacin and Lomefloxacin in vivo and in vitro

Fuentes

Martín²,

Izquierdo³

et al. 1996

Chemotherapy

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The present study investigates the postantibiotic effect (PAE) in vivo, and the postantibiotic subinhibitory concentration effects (PA-SE) in vitro and SE in vivo of three 4-fluoroquinolones (ciprofloxacin, fleroxacin and lomefioxacin) against standard strains of Staphylococcus aureus and Escherichia coli. In vivo killing kinetics have also been performed using two different short administrations to study if the PAE duration could cover the time that the antibiotic was below the minimal inhibitory concentration (MIC) in serum. The results show that the three antimicrobial agents induced long PAEs (1.9–3.1 h) against the two microorganisms. Moderate but significant in vitro PA-SEs were also produced (1– > 9 h). The in vivo SEs were not significant except when the effect of lomefioxacin on E. coli was assayed (0.54 h). Finally, the in vivo killing kinetics showed that the administrations that included the PAE duration were as effective as the schedule that maintained the antibiotic levels in serum above the MIC. Only when fleroxacin and S. aureus were assayed, this last administration was more effective (+ 0.9 log₁₀ colony-forming units/thigh).

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Postantibiotic Effect, and Postantibiotic Effect of Subinhibitory Concentrations, of Sparfloxacin on Gram-Negative Bacteria

Cited by 23 publications

References 18 publications

Cell surface hydrophobicity and adherence of a strain of group B streptococci during the post-antibiotic effect of penicillin

Cell surface hydrophobicity and adherence of a strain of group B streptococci during the post-antibiotic effect of penicillin

Evaluation of post‐antibiotic effects of antipseudomonal antibiotics using an automated system

Pharmacodynamic Effects of Ciprofloxacin, Fleroxacin and Lomefloxacin in vivo and in vitro

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