Postconditioning A new link in nature’s armor against myocardial ischemia–reperfusion injury

Vinten‐Johansen, Jakob; Zhao, Zhi‐Qing; Zatta, Amanda J.; Kin, Hajime; Halkos, Michael E.; Kerendi, Faraz

doi:10.1007/s00395-005-0523-x

Cited by 196 publications

(186 citation statements)

References 84 publications

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“…The first seconds of reperfusion seem to be critical for the cardioprotection mechanism of postconditioning. In the isolated rat heart, the algorithm of ischemia and reperfusion of 30/30s does not decrease the infarcted area [6,7]. Similarly, the use of three cycles of reperfusion and ischemia, both with equal length of 30s in the pig heart in situ has no cardioprotective effect, suggesting that the algorithm is different from the dog heart in situ, in addition to variations on collateral circulation between the two species.…”

Section: Discussionmentioning

confidence: 94%

“…The biological expression of these mediators seems to depend on the time of reperfusion/ischemia and animal species. Therefore, it has been suggested that: 1) the length of ischemia and reperfusion in the postconditioning protocol is species-dependent, 2) the number of cycles of ischemia and reperfusion seems to be less important than its length [6,7].…”

Section: Discussionmentioning

confidence: 99%

“…Data from literature have suggested that ischemic postconditioning is powerful endogenous mechanism of cardioprotection, because it reduces the infracted area [5], endothelial dysfunction [5], adhesion of neutrophils to vascular endothelium [6], formation of reactive oxygen species [27], reperfusion arrhythmias [15.27], myocardial edema [7] and apoptosis [6] and may require major change in the paradigms of myocardial protection.…”

Section: Discussionmentioning

confidence: 99%

“…In the isolated rat heart, the algorithm of reperfusion and ischemia, both with equal length of 30s, did not reduce the infarcted area [6,7]. In the indexed literature (Medline/ Pubmed), functional assessment of isolated rat hearts undergone different algorithms of ischemic postconditioning was not found.…”

Section: Introductionmentioning

confidence: 94%

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Efeitos do pós-condicionamento isquêmico na função ventricular esquerda de corações isolados de ratos

Pinheiro¹,

Fiorelli²,

Gomes³

2009

Rev Bras Cir Cardiovasc

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Efeitos do pós-condicionamento isquêmico na função ventricular esquerda de corações isolados de ratosEffects of ischemic postconditioning on left ventricular function of isolated rat hearts Abstract Objective: To assess the effects of ischemic postconditioning on left ventricular function in isolated rat hearts.Methods: Twenty-four Wistar rats were used. These hearts underwent perfusion by modified LANGERDORFF method and distributed into three groups: GI -control (n=8); GII -three cycles of postconditioning of 10/10s (n=8); GIIIthree cycles of postconditioning of 30/30s (n=8). After a 15min stabilization period, all hearts underwent 20min of global ischemia following 20min of reperfusion. In the times 0 (control), 5, 10, 15 and 20min of reperfusion, the heart rate (HR), the coronary flow (CoF), the systolic pressure, the (+dP/dt max) contractility and (-dP/dt max) velocity of relaxation were measured. Data were analyzed by ANOVA method followed by Tukey's test for differences between groups and P < 0.05 was considered significant. Rev Bras Cir Cardiovasc 2009; 24(1): 31-37

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

See 2 more Smart Citations

Efeitos do pós-condicionamento isquêmico na função ventricular esquerda de corações isolados de ratos

Pinheiro¹,

Fiorelli²,

Gomes³

2009

Rev Bras Cir Cardiovasc

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“…Reducing size of infarcted area afforded by postCI has been observe in different species, including pigs, dogs, rabbits, mice and rats 41 .…”

Section: ■ Discussionmentioning

confidence: 97%

Cardioprotective effect of preconditioning is more efficient than postconditioning in rats submitted to cardiac ischemia and reperfusion

et al. 2018

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Cardioprotective effect of preconditioning is more efficient than postconditioning in rats submitted to cardiac ischemia and reperfusion 1 AbstractPurpose: To investigate the cardioprotective effects of ischemic preconditioning (preIC) and postconditioning (postIC) in animal model of cardiac ischemia/reperfusion. Methods: Adult rats were submitted to protocol of cardiac ischemia/reperfusion (I/R) and randomized into three experimental groups: cardiac I/R (n=33), preCI + cardiac I/R (n=7) and postCI + cardiac I/R (n=8). After this I/R protocol, the incidence of ventricular arrhythmia (VA), atrioventricular block (AVB) and lethality (LET) was evaluated using the electrocardiogram (ECG) analysis. Results: After reestablishment of coronary blood flow, we observed variations of the ECG trace with increased incidence of ventricular arrhythmia (VA) (85%), atrioventricular block (AVB) (79%), and increase of lethality (70%) in cardiac I/R group. The comparison between I/R + preIC group with I/R group demonstrated significant reduction in VA incidence to 28%, AVB to 0% and lethality to 14%. The comparison of I/R + postIC group with I/R group was observed significance reduction in AVB incidence to 25% and lethality to 25%. Conclusion:The preconditioning strategies produce cardioprotection more efficient that postconditioning against myocardial dysfunctions and lethality by cardiac ischemia and reperfusion.

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Protective effects of ischemic postconditioning compared with gradual reperfusion or preconditioning

Gao

Ren

Zhao

2008

J of Neuroscience Research

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We examined the temporal factors of postconditioning, assessed whether gradual reperfusion reduces infarcts, and compared postconditioning's protection with that of both rapid and delayed preconditioning. Focal ischemia was generated by permanent occlusion of the left distal middle cerebral artery (dMCA) combined with 30 min of occlusion of both common carotid arteries (CCA) in rats. Postconditioning was performed by repetitive brief release and occlusion of CCA after 30 min of CCA occlusion. Gradual reperfusion was generated by controlled release of the bilateral CCA. We confirmed that postconditioning disrupted the early reperfusion but improved cerebral blood flow (CBF) thereafter. Postconditioning with three cycles, but not with 10 cycles, of 30 sec CCA release and 10 sec CCA occlusion (30s/10s) reduced infarction measured at 2 days after stroke. In addition, postconditioning with 10 cycles, but not with three cycles, of 10s/10s reduced infarction but it lost protection when initiated at 3 min after reperfusion. In addition, gradual reperfusion also reduced infarction. Moreover, both rapid and delayed preconditioning conducted 60 min and 3 days before stroke reduced infarct sizes. However, no additional protection was detected when postconditioning was combined with either rapid or delayed preconditioning. In conclusion, gradual reperfusion reduced infarction; postconditioning's protection depended on the number of cycles and duration of each cycle of reperfusion and occlusion and the onset time of postconditioning; postconditioning's protection was comparable to that of rapid preconditioning but not as robust as that of delayed preconditioning.

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Postconditioning A new link in nature’s armor against myocardial ischemia–reperfusion injury

Cited by 196 publications

References 84 publications

Efeitos do pós-condicionamento isquêmico na função ventricular esquerda de corações isolados de ratos

Efeitos do pós-condicionamento isquêmico na função ventricular esquerda de corações isolados de ratos

Cardioprotective effect of preconditioning is more efficient than postconditioning in rats submitted to cardiac ischemia and reperfusion

Protective effects of ischemic postconditioning compared with gradual reperfusion or preconditioning

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