Postdosing colic and diarrhoea in horses with serological evidence of tapeworm infection

Barrett, Eugene J.; Blair, Caroline; Farlam, J.; Proudman, C. J.

doi:10.1136/vr.156.8.252

Cited by 11 publications

(2 citation statements)

References 16 publications

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“…A noteworthy observation was that horses, which had received an anthelmintic treatment (only MLs, pyrantel and praziquantel) during the week prior to hospitalization, had a significant, i.e., 2.4 times, higher risk for colic than patients receiving anthelmintic treatment a longer time ago. A similar observation was made by Barret et al [ 44 ], who described the onset of colic and diarrhea within 12 h post treatment with a combination of ivermectin and praziquantel in horses seropositive for A. perfoliata . Another study also reported on the potential for the development of colic signs within 24 h post anthelmintic treatment, but this only in Parascaris infected horses with an age of up to 12 months where prior treatment with either MLs or pyrantel led to small intestinal obstruction through the present ascarids [ 6 ].…”

Section: Discussionsupporting

confidence: 82%

Comparative Analysis of Intestinal Helminth Infections in Colic and Non-Colic Control Equine Patients

Gehlen

Wulke

Ertelt

et al. 2020

Animals

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All around the world, intestinal helminths constitute one of the most prevalent life-long occurring infections and re-infections affecting all horse age groups. A range of parasite species among strongyles, ascarids, and tapeworms is known to have the potential to cause colic in horses. However, there is a lack of current scientific evidence on the actual relevance of helminth infection levels in the context of colic in horses kept during prevailing epidemiological conditions. Thus, a prospective case-control study on the occurrence of intestinal helminths in a total of 620 mainly adult equine clinic patients was conducted to investigate the association between colic and helminth infection. For each horse, a range of copromicroscopic, serological, and clinical data was obtained, in addition to a questionnaire on relevant anamnestic data, including previous anthelmintic treatment and husbandry. Using a FLOTAC-based copromicroscopic diagnosis, the highest infection rates were seen for strongyles (41.8%), followed by Anoplocephala perfoliata and Parascaris spp. (both 0.8%), with no significant difference between the two study groups. Employing a real-time PCR a 1.1% S. vulgaris DNA prevalence was found. Considerably higher seroprevalences were observed using S. vulgaris and A. perfoliata ELISAs, with 32.3% and 10.7%, respectively. It was noteworthy that no association concerning either serologic status was encountered with colic status. The shedding of strongyle eggs was associated with a 1.8-times increased risk of S. vulgaris seropositivity. Recent anthelmintic treatment was associated with the onset of colic, as animals who had received an anthelmintic during the previous week had a 2.4-times higher risk of signs of colic compared to those who had been treated at least eight weeks prior. Another noteworthy observation was that ponies were significantly less often affected by colic than warmbloods. The high S. vulgaris and considerable A. perfoliata seroprevalences encountered in this investigation should prompt veterinarians, farm managers, and horse owners to maintain consequent and effective worm control measures.

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Section: Discussionsupporting

confidence: 82%

Comparative Analysis of Intestinal Helminth Infections in Colic and Non-Colic Control Equine Patients

Gehlen

Wulke

Ertelt

et al. 2020

Animals

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“…The potential of tapeworms to induce colic in horses has been documented [ 26 - 28 ] and combining MOX with the potent cestocide praziquantel allows simultaneous treatment of roundworms and tapeworms in a single application. The efficacy and safety of this combination product was demonstrated in a large field evaluation where four hundred client-owned horses were treated with either the combination of MOX + praziquantel or control.…”

Section: Efficacy and Safetymentioning

confidence: 99%

Moxidectin: a review of chemistry, pharmacokinetics and use in horses

Cobb¹,

Boeckh²

2009

Parasites Vectors

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This article reviews the current knowledge of the use of moxidectin (MOX) in horses, including its mode of action, pharmacokinetic and pharmacodynamic properties, efficacy, safety and resistance profile. Moxidectin is a second generation macrocyclic lactone (ML) with potent endectocide activity. It is used for parasite control in horses in an oral gel formulation.The principal mode of action of MOX and of other MLs is binding to gamma-aminobutyric (GABA) and glutamate-gated chloride channels. Moxidectin is different from other MLs in that it is a poor substrate for P-glycoproteins (P-gps) and therefore less susceptible to elimination from parasite cells through this mechanism. Due to its unique physico-chemical and pharmacokinetic characteristics, MOX provides broad distribution into tissues, long half-life, significant residual antiparasitic activity, and high efficacy against encysted cyathostomin larvae. These characteristics allow for high efficacy and longer treatment interval against all important nematodes, when compared to other equine anthelmintics. A combination of MOX with praziquantel provides expanded spectrum of activity by adding activity against cestodes.Appropriate use of MOX allows for the development of strategic anthelmintic programmes that are different from those with conventional anthelmintics. Fewer treatments are required over a period of time, and therefore impose less frequent selection pressure for resistance.

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Long‐Term Recovery and Prevention

Southwood

2012

Practical Guide to Equine Colic

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Postdosing colic and diarrhoea in horses with serological evidence of tapeworm infection

Cited by 11 publications

References 16 publications

Comparative Analysis of Intestinal Helminth Infections in Colic and Non-Colic Control Equine Patients

Comparative Analysis of Intestinal Helminth Infections in Colic and Non-Colic Control Equine Patients

Moxidectin: a review of chemistry, pharmacokinetics and use in horses

Long‐Term Recovery and Prevention

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