Postelectrospinning modifications for alginate nanofiber‐based wound dressings

Leung, Victor C. M.; Hartwell, Ryan; Elizei, Sanam Salimi; He, Yunhui; Ghahary, Aziz; Ko, Frank

doi:10.1002/jbm.b.33028

Cited by 51 publications

(33 citation statements)

References 18 publications

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“…The natural polysaccharide alginate has also been proposed as suitable building materials in wound dressings. There are numerous studies concerning the application of different alginate-based formulations: chitosan-fibrin-sodium alginate composite for wound dressings [72], alginate nanofiber-based wound dressings [73], sodium alginate/poly(ethylene oxide) blend nanofibers [74], composite alginate, and gelatin-based bio-polymeric wafers for wound healing [75] and so on.…”

Section: Methodsmentioning

confidence: 99%

Smart Dressings Based on Nanostructured Fibers Containing Natural Origin Antimicrobial, Anti-Inflammatory, and Regenerative Compounds

et al. 2015

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A fast and effective wound healing process would substantially decrease medical costs, wound care supplies, and hospitalization significantly improving the patients’ quality of life. The search for effective therapeutic approaches seems to be imperative in order to avoid the aggravation of chronic wounds. In spite of all the efforts that have been made during the recent years towards the development of artificial wound dressings, none of the currently available options combine all the requirements necessary for quick and optimal cutaneous regeneration. Therefore, technological advances in the area of temporary and permanent smart dressings for wound care are required. The development of nanoscience and nanotechnology can improve the materials and designs used in topical wound care in order to efficiently release antimicrobial, anti-inflammatory and regenerative compounds speeding up the endogenous healing process. Nanostructured dressings can overcome the limitations of the current coverings and, separately, natural origin components can also overcome the drawbacks of current antibiotics and antiseptics (mainly cytotoxicity, antibiotic resistance, and allergies). The combination of natural origin components with demonstrated antibiotic, regenerative, or anti-inflammatory properties together with nanostructured materials is a promising approach to fulfil all the requirements needed for the next generation of bioactive wound dressings. Microbially compromised wounds have been treated with different essential oils, honey, cationic peptides, aloe vera, plant extracts, and other natural origin occurring antimicrobial, anti-inflammatory, and regenerative components but the available evidence is limited and insufficient to be able to draw reliable conclusions and to extrapolate those findings to the clinical practice. The evidence and some promising preliminary results indicate that future comparative studies are justified but instead of talking about the beneficial or inert effects of those natural origin occurring materials, the scientific community leads towards the identification of the main active components involved and their mechanism of action during the corresponding healing, antimicrobial, or regenerative processes and in carrying out systematic and comparative controlled tests. Once those natural origin components have been identified and their efficacy validated through solid clinical trials, their combination within nanostructured dressings can open up new avenues in the fabrication of bioactive dressings with outstanding characteristics for wound care. The motivation of this work is to analyze the state of the art in the use of different essential oils, honey, cationic peptides, aloe vera, plant extracts, and other natural origin occurring materials as antimicrobial, anti-inflammatory and regenerative components with the aim of clarifying their potential clinical use in bioactive dressings. We conclude that, for those natural occurring materials, more clinical trials are needed to reach a sufficient level ...

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Section: Methodsmentioning

confidence: 99%

Smart Dressings Based on Nanostructured Fibers Containing Natural Origin Antimicrobial, Anti-Inflammatory, and Regenerative Compounds

et al. 2015

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“…In recent years, novel designed wound dressing have been suggested to accelerate wound healing. nanofibers based dressings have shown effective results, due to their high specific surface area [6], porous structure [7] and high porosity [8]. Moreover these porous nanofibers can mimic the micromorphology of the native extracellular matrix (ECM) and enhance the cell migration and proliferation [9].…”

Section: Introductionmentioning

confidence: 99%

Solution blowing of chitosan/PLA/PEG hydrogel nanofibers for wound dressing

Zhou

et al. 2016

Fibers Polym

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In this study, a kind of hydrogel nanofibers were successfully fabricated via solution blowing of chitosan (CS) and polylactic acid (PLA) solutions mixed with various contents of polyethylene glycol (PEG) to offer hydration. The nanofibers with PEG content varying were average 341-376 nm in diameter with smooth surface and distributed randomly forming three-dimension (3D) mats. Glutaraldehyde (GA) vapor was then applied to impart stability, and the cross-linking reaction mainly occurred between GA and hydroxyl groups which was confirmed by XPS. The hydrogel nanofibers showed quick absorption behavior, high equilibrate water absorption and good air permeability which could help the mats absorbing excess exudates, creating a moist wound healing environment and oxygen exchanging in wound healing. The mats also exhibited good antibacterial activities against E. coil. The combination advantages of nanofibers mats and hydrogel will help it find promising application in wound healing.

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“…Electrospun nanofibers due to the high porosity and large specific surface (area to volume ratio) with small pore size have a good potential for the biomedical applications [1,2]. In recent years, biocompatible nanofibers have been developed for different applications such as drug delivery systems [3][4][5][6], tissue engineering [7][8][9][10], wound dressing [11][12][13][14] and biomedical applications [15,16].…”

Section: Introductionmentioning

confidence: 99%

Fabrication of PEO/chitosan/PCL/olive oil nanofibrous scaffolds for wound dressing applications

et al. 2015

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Biodegradable polyethylene oxide (PEO)/chitosan (CS)/poly(ε-caprolactone) (PCL)/olive oil composite nanofibers were fabricated by electrospinning process. The prepared nanofibers were characterized using SEM and FTIR analysis. A response surface methodology based on Box-Behnken design (BBD) was used to predict the average diameter of electrospun nanofibers based on electrospinning parameters including voltage, flow rate and tip-collector distance. The optimum experimental average diameter of electrospun nanofibers was found to be 86 nm which was in good agreement with the predicted value by the BBD analysis (88 nm). In vitro release of olive oil incorporated PEO/CS/PCL/olive oil nanofibers demonstrated a rapid release of olive oil during the first 3 h which enhanced gradually afterwards. Good attachment, spreading, cell proliferation, as well as nontoxic behavior of PEO/CS/PCL/olive oil nanofibrous scaffolds on HDF fibroblast cells were proved by cytotoxicity studies. Furthermore, the high antibacterial activity of PEO/CS/PCL/olive oil composite nanofibers against Gram-negative bacteria E. coli and Gram-positive S. aureus was observed. This study suggests that the prepared PEO/CS/PCL/olive oil composite nanofibrous scaffolds could be used as an ideal patch for wound dressing applications.

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Postelectrospinning modifications for alginate nanofiber‐based wound dressings

Cited by 51 publications

References 18 publications

Smart Dressings Based on Nanostructured Fibers Containing Natural Origin Antimicrobial, Anti-Inflammatory, and Regenerative Compounds

Smart Dressings Based on Nanostructured Fibers Containing Natural Origin Antimicrobial, Anti-Inflammatory, and Regenerative Compounds

Solution blowing of chitosan/PLA/PEG hydrogel nanofibers for wound dressing

Fabrication of PEO/chitosan/PCL/olive oil nanofibrous scaffolds for wound dressing applications

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