Poster 30: Triamcinolone Acetonide Aqueous Nasal Spray (Nasacort Aqueous) Relieves the Symptoms of Seasonal Ragweed Allergic Rhinitis

Settipane, Guy A.; Korenblat, Philip; Winder, John; Lumry, William R.; Murphree, J.J.; Alderfer, Vivian; Simpson, Brandon; Smith, Joseph A.

doi:10.1016/s0194-5998(05)80806-x

Cited by 3 publications

(2 citation statements)

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“…Our results support those of a previous study comparing the same doses of TAA AQ and FP, in which both products demonstrated comparable efficacy in relieving rhinitis symptoms and improving HRQL in patients with fall SAR. 5 No placebo arm was used in this trial, because TAA AQ and FP are already well established to be effective for the treatment of allergic rhinitis; [14][15][16] furthermore, we wanted this study to reflect the real-life use of these medications.…”

Section: Discussionmentioning

confidence: 99%

Triamcinolone acetonide aqueous nasal spray and fluticasone propionate are equally effective for relief of nasal symptoms in patients with seasonal allergic rhinitis

Berger

Kaiser

Gawchik³

et al. 2003

Otolaryngol.--head neck surg.

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OBJECTIVE: We compared 220 µg daily intranasal aqueous triamcinolone acetonide (TAA AQ) with 200 µg daily fluticasone propionate (FP) for relief of seasonal allergic rhinitis symptoms. STUDY DESIGN AND SETTING: Randomized, parallel-group, investigator-blind study included patients with symptomatic seasonal allergic rhinitis. After a baseline period, TAA AQ or FP was taken for about 21 days. Nasal symptom (discharge, stuffiness, itching, sneezing) severity was recorded twice daily; total nasal symptom score was calculated. Health-related quality of life was assessed by Rhinoconjunctivitis Quality of Life Questionnaire. RESULTS: Reductions in individual symptoms and total nasal symptom score were statistically significant versus baseline and were equivalent between treatments: −3.15 ± 0.19 with TAA AQ (n = 148) and ∼3.17 ± 0.18 with FP (n = 147) (95% confidence interval for the difference, −0.7391 to 0.3693). Clinically and statistically significant improvements in Rhinoconjunctivitis Quality of Life Questionnaire scores were comparable. CONCLUSION: TAA AQ and FP were equally efficacious in relieving seasonal allergic rhinitis symptoms and improving health-related quality of life. SIGNIFICANCE: Differences in molecular potency of intranasal steroids do not confer differences in efficacy.

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Section: Discussionmentioning

confidence: 99%

Triamcinolone acetonide aqueous nasal spray and fluticasone propionate are equally effective for relief of nasal symptoms in patients with seasonal allergic rhinitis

Berger

Kaiser

Gawchik³

et al. 2003

Otolaryngol.--head neck surg.

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“…Nevertheless, a number of studies have shown that intranasal steroids are significantly more effective than placebo in reducing ocular symptoms in AR patients. In an early trial, total ocular symptoms were significantly lower after treatment with triamcinolone acetonide vs. placebo [8].…”

Section: Role Of Intranasal Corticosteroids For Management Of Ocular mentioning

confidence: 99%

What has the relief of allergic conjunctivitis by intranasal steroids taught us about the pathophysiology of allergic rhinoconjunctivitis?

Naclerio

Baroody

2009

Clin Exp All Rev

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Summary Patients with allergic rhinitis (AR) report ocular symptoms 40–70% of the time. These symptoms can be burdensome and have a major impact on patients' quality of life. Most clinicians believe that ocular symptoms result from direct contact of allergen with the conjunctiva, although other explanations such as a nasal‐ocular reflex, blockage of the nasal lacrimal duct, and systemic effects of cytokines released from the nasal mucosa can explain the association. However, if direct contact by an allergen is the sole explanation, how do we explain the efficacy of intranasal steroids on the eye symptoms of AR, especially because most intranasal steroids have <0.5% systemic bioavailability? This paper highlights a potential mechanism for the development of ocular symptoms after nasal exposure to antigen, the nasal‐ocular reflex, and speculates how intranasal steroids can affect this reflex and eye symptoms. Two nasal‐challenge studies assessing the nasal‐ocular reflex are presented. The first shows the presence of a nasal‐ocular reflex in response to localized nasal‐antigen challenge, which is initiated by the release of histamine and blocked by a topical, intranasal antihistamine. The second study shows that the nasal‐ocular reflex is augmented with repeated nasal antigen challenge, a response that is inhibited by pretreatment with an intranasal steroid. These studies provide an explanation for the way in which treatment with intranasal steroids can work locally in the nose to reduce ocular symptoms in patients with AR. This explanation, however, would only be valid if the majority of eye symptoms in patients with AR were caused by the nasal‐ocular reflex and not by direct contact of antigen with the conjunctiva – an assumption supported by clinical studies.

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Triamcinolone acetonide aqueous nasal spray and fluticasone propionate are equally effective for relief of nasal symptoms in patients with seasonal allergic rhinitis

Berger¹,

Kaiser

Gawchik³

et al. 2003

Otolaryngology - Head and Neck Surgery

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Poster 30: Triamcinolone Acetonide Aqueous Nasal Spray (Nasacort Aqueous) Relieves the Symptoms of Seasonal Ragweed Allergic Rhinitis

Cited by 3 publications

References 0 publications

Triamcinolone acetonide aqueous nasal spray and fluticasone propionate are equally effective for relief of nasal symptoms in patients with seasonal allergic rhinitis

Triamcinolone acetonide aqueous nasal spray and fluticasone propionate are equally effective for relief of nasal symptoms in patients with seasonal allergic rhinitis

What has the relief of allergic conjunctivitis by intranasal steroids taught us about the pathophysiology of allergic rhinoconjunctivitis?

Triamcinolone acetonide aqueous nasal spray and fluticasone propionate are equally effective for relief of nasal symptoms in patients with seasonal allergic rhinitis

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