2022
DOI: 10.1093/cvr/cvac157.097
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Poster No. 117 rs12526196 polymorphism in CCN2 gene is an independent risk factor for ascending thoracic aortic aneurysm

Abstract: Background The Cellular Communication Network Factor-2 (CCN2/CTGF) has been traditionally described as a downstream mediator of other profibrotic factors including transforming growth factor (TGF)-ß and Angiotensin II. However, recent evidence from our group demonstrated the direct role of CCN2 in maintaining aortic wall homeostasis and, in addition, the development of acute and lethal aortic aneurysm induced by Angiotensin II in absence of CCN2 in mice. In order to translate these findings t… Show more

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