Posterior capsule management in congenital cataract surgery

Vasavada, Abhay R.; Praveen, Mamidipudi R.; Tassignon, Marie-José; Shah, Sajani K.; Vasavada, Vaishali; Looveren, Jan Van; Veuster, Ilse De; Trivedi, Rupal H.

doi:10.1016/j.jcrs.2010.10.036

Cited by 99 publications

(94 citation statements)

References 105 publications

(152 reference statements)

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“…Visually significant VAO is a common complication after pediatric cataract surgery and can be amblyogenic, occurring in up to 71% of pediatric patients who receive primary PPC-AntVx and virtually 100% of pediatric patients who have the capsule left intact [7]. This is consistent with our data in which 80% of the patients who had the capsule left intact required treatment for VAO within 2.5 years of the original cataract surgery.…”

Section: Discussionsupporting

confidence: 90%

“…This is consistent with our data in which 80% of the patients who had the capsule left intact required treatment for VAO within 2.5 years of the original cataract surgery. In young children or patients who are developmentally delayed, PPC-AntVx is routinely performed due to a high risk of development of VAO soon after cataract surgery [7]; in our study, this procedure reduced the development of VAO from 80% to 40%. If possible, we prefer to manage VAO with Nd:YAG laser capsulotomy, but many of our patients required a surgical posterior capsulotomy with anterior vitrectomy due to developmental delay causing inability to cooperate or, even when cooperation was good, nystagmus causing eye movement during the procedure.…”

Section: Discussionmentioning

confidence: 48%

“…Cataracts occur frequently in this high risk population [2] [3] and cataract surgery may be complicated due to history of previous vitreoretinal surgery or ocular changes due to the ROP. Postoperative management may present additional challenges due to refractive changes over time, visual axis opacification (VAO), and anatomic retinal changes [4] [5] [6] [7].…”

mentioning

confidence: 99%

“…Studies have evaluated the possibility of anterior segment ischemia as a potential cause and have not found that earlier treatment for the ROP reduces the incidence of cataract development [7].…”

mentioning

confidence: 99%

“…Because these patients have many other vision limiting comorbidities, the presence of cataracts can pose a serious threat to the development of vision in these patients [7]. The purpose of our study is to report the surgical and visual outcomes of cataract surgery in pediatric patients who have had treatment for ROP.…”

mentioning

confidence: 99%

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Outcome of Cataract Surgery in Patients Treated for Retinopathy of Prematurity

Nguyen¹,

Yen²

2017

OJOph

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Background/Aims: Pediatric patients with treated retinopathy of prematurity (ROP) may develop visually significant cataracts. We report the outcome of cataract surgery in patients who had ROP treatment. Method: Retrospective chart review of 19 eyes from 16 patients who had ROP treatment and subsequent cataract surgery between August, 2002 and March, 2015. Results: Eighteen of 19 eyes received laser treatment for ROP; 1 eye received intravitreal bevacizumab. 5 eyes received lens-sparing pars plana vitrectomy (LSPPV) in addition to laser. Average follow up was 10.1 ± 5.5 years. Average visual acuity improved from 20/324 prior to and 20/110 after cataract surgery (p = 0.06). 13/19 (68%) of the eyes received laser only and developed cataracts an average of 6.2 ± 5.6 years after laser treatment. 5/19 (26%) eyes developed cataracts an average of 6.4 ± 4.2 years after LSPPV and laser. In one eye, a cataract developed after a bevacizumab injection 2.9 years after the injection. Visual axis opacification (VAO) developed in 2/5 (40%) eyes after Ce/PCIOL/PPC-Antvx, 8/10 eyes (80%) after CE/IOL, and in 0/4 eyes after CE/PPC-AntVx. Ocular comorbidities included strabismus, nystagmus, amblyopia, optic atrophy, corneal band keratopathy, and phthisis bulbi. Conclusion: Cataract surgery in patients who have a history of ROP can be complicated by anatomical changes from prematurity and prior vitreoretinal surgeries. Vision improvement is limited by other ocular comorbidities.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 48%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Outcome of Cataract Surgery in Patients Treated for Retinopathy of Prematurity

Nguyen¹,

Yen²

2017

OJOph

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Fibrosis: Shared Lessons From the Lens and Cornea

Menko

Walker

Stepp

2019

The Anatomical Record

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Regenerative repair in response to wounding involves cell proliferation and migration. This is followed by the reestablishment of cell structure and organization and a dynamic process of remodeling and restoration of the injured cells' extracellular matrix microenvironment and the integration of the newly synthesized matrix into the surrounding tissue. Fibrosis in the lungs, liver, and heart can lead to loss of life and in the eye to loss of vision. Learning to control fibrosis and restore normal tissue function after injury repair remains a goal of research in this area. Here we use knowledge gained using the lens and the cornea to provide insight into how fibrosis develops and clues to how it can be controlled. The lens and cornea are less complex than other tissues that develop life-threatening fibrosis, but they are well characterized and research using them as model systems to study fibrosis is leading toward an improved understanding of fibrosis. Here we summarize the current state of the literature and how it is leading to promising new treatments.

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Screening, genetics, risk factors, and treatment of neonatal cataracts

Xia

Wang

et al. 2017

Birth Defects Research

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Neonatal cataracts remain the most common cause of visual loss in children worldwide and have diverse, often unknown, etiologies. This review summarizes current knowledge about the detection, treatment, genetics, risk factors, and molecular mechanisms of congenital cataracts. We emphasize significant progress and topics requiring further study in both clinical cataract therapy and basic lens research. Advances in genetic screening and surgical technologies have improved the diagnosis, management, and visual outcomes of affected children. For example, mutations in lens crystallins and membrane/cytoskeletal components that commonly underlie genetically inherited cataracts are now known. However, many questions still remain regarding the causes, progression, and pathology of neonatal cataracts. Further investigations are also required to improve diagnostic criteria for determining the timing of appropriate interventions, such as the implantation of intraocular lenses and postoperative management strategies, to ensure safety and predictable visual outcomes for children. Birth Defects Research 109:734-743, 2017. © 2017 Wiley Periodicals, Inc.

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Posterior capsule management in congenital cataract surgery

Abstract: No author has a financial or proprietary interest in any material or method mentioned.

Cited by 99 publications

References 105 publications

Outcome of Cataract Surgery in Patients Treated for Retinopathy of Prematurity

Outcome of Cataract Surgery in Patients Treated for Retinopathy of Prematurity

Fibrosis: Shared Lessons From the Lens and Cornea

Screening, genetics, risk factors, and treatment of neonatal cataracts

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