Posterior capsule opacification rate after phacoemulsification in pediatric cataract: Hydrophilic versus hydrophobic intraocular lenses

Sen, Pradhnya; Kshetrapal, Mansi; Shah, Chintan; Mohan, Akhilesh; Jain, Elesh; Sen, Alok

doi:10.1016/j.jcrs.2019.05.018

Cited by 23 publications

(23 citation statements)

References 20 publications

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“…In some long-term observations, hydrophobic IOLs supposedly outstand hydrophilic lenses in terms of economic results with lower PCO rates [15]. However, a comparison of hydrophilic and hydrophobic lenses in pediatric patients found the same rate of PCO development in both materials [16]. The authors found that IOL material was less important in PCO formation than their surgical technique including primary posterior capsulotomy and anterior vitrectomy.…”

Section: Discussionmentioning

confidence: 97%

Analysis of YAG Laser-Induced Damage in Intraocular Lenses: Characterization of Optical and Surface Properties of YAG Shots

Borkenstein

2020

Ophthalmic Res

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Purpose To assess differences in Nd:YAG induced defects in hydrophilic and hydrophobic IOLs and describe optical and surface properties of YAG-shots/pitting. Describing and measuring the iatrogenic produced defects should achieve higher awareness on this topic and change the mindset of such a trivial procedure to be proceeded with more caution and calmness in the future. Materials 12 IOLs from different manufacturers made of hydrophilic and hydrophobic materials were evaluated before and after treatment with Nd:YAG laser. Microscopy and Environmental scanning electron microscopy were used to visually analyze the defects. Additionally, wavefront measurements were taken for power mapping and Raman spectroscopy was performed. Vertical and horizontal dimensions of the defects were analyzed and compared, and Raman line scans assessed the changes in the chemical structure in the defect area of the IOL. Results Microscopically, pitting of the surface could be observed in both lens types. Defects in hydrophobic lenses appeared bigger and were visible with less magnification than in hydrophilic lenses. Similar results were obtained with ESEM images were the defects in hydrophobic IOLs seemed to be frayed while defects in hydrophilic IOLs were of circular shape. Raman spectroscopy revealed deeper defects in hydrophobic lenses. Vertical dimensions of the defects were statistically significant (p=0.036) greater in hydrophobic materials while horizontal dimensions did not reach significance (p=0.056). The area of chemical changes was greater than the visible defect area and smaller in hydrophilic than in hydrophobic materials. Conclusion Nd:YAG seems to have greater impact on hydrophobic IOL materials as those damages were greater and more frayed than in hydrophilic materials. Moreover, there seems to be larger, distinctive damage areas in IOLs (with chemical changes in the material) than is visually recognizable. Therefore, a very cautious approach is recommended when performing capsulotomy, as defects in the surface structure can occur. This might come along with problems in quality of vision in monofocal and primarily premium IOLs, dependent on the size, dimension and position in the IOL. YAG-capsulotomy should not be considered trivial but should be carried out with precision and without time pressure, just like surgery itself.

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Section: Discussionmentioning

confidence: 97%

Analysis of YAG Laser-Induced Damage in Intraocular Lenses: Characterization of Optical and Surface Properties of YAG Shots

Borkenstein

2020

Ophthalmic Res

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“…Hydrophobic acrylic IOL material has certain advantages over other materials: a lower rate of posterior capsule opacification compared to hydrophilic acrylate and PMMA IOLs, and absence of complications associated with hydrophilic acrylate lenses like IOL calcification [31][32][33]. For these reasons, hydrophobic acrylic IOLs gained popularity and are now widely used despite the known long-term material changes like glistenings and SSNG [7].…”

Section: Plos Onementioning

confidence: 99%

Quantitative evaluation of microvacuole formation in five intraocular lens models made of different hydrophobic materials

et al. 2021

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In this laboratory study, we assessed the resistance to microvacuole (glistening) formation in hydrophobic intraocular lenses (IOLs). Glistenings were induced in five lenses each of five different hydrophobic acrylic IOL models, using an established in vitro laboratory model: 800C (Rayner, Worthing, UK), AcrySof SN60WF (Alcon, Fort Worth, USA), Tecnis ZCB00 (Johnson & Johnson Vision, Santa Ana, USA), Vivinex XY1 (Hoya, Tokyo, Japan) and CT Lucia 611P (Zeiss, Oberkochen, Germany). We evaluated the number of microvacuoles per square millimeter (MV/mm2) in the central part of each IOL. Results were analyzed statistically, and mean glistening numbers were ranked, with the highest in the SN60WF which had 66.0 (±45.5) MVs/mm, followed by the 611P with 30.7 (±8.4) MVs/mm2. The 800C and XY1 showed comparable values of 2.0 (±3.6) and 2.7 (±2.4) MVs/mm2, respectively. ZCB00 had the lowest number with 0.9 (±0.6) MVs/mm2. This study shows that the resistance to glistening formation differs depending on the hydrophobic acrylic copolymer composition of the IOL material. Some IOLs from current clinical use are still prone to develop glistenings whereas others, including the ZCB00, 800C and XY1 show high resistance to microvacuole formation.

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“…However, surgical wound healing and foreign body reactions often lead to multiple complications, among which posterior capsular opacification (PCO) is the most common complication of cataract surgery. It is reported that the incidence of PCO is 20–40% in adults and up to 100% in children within 2–5 years after surgery [ 5 , 6 ]. The main cause of PCO is the proliferation, migration and differentiation of residual lens epithelial cells (LECs) adhering to the IOL surface and posterior capsule [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Augmented cellular uptake and homologous targeting of exosome-based drug loaded IOL for posterior capsular opacification prevention and biosafety improvement

Zhu

Huang

Liu

et al. 2022

Bioactive Materials

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Posterior capsule opacification rate after phacoemulsification in pediatric cataract: Hydrophilic versus hydrophobic intraocular lenses

Cited by 23 publications

References 20 publications

Analysis of YAG Laser-Induced Damage in Intraocular Lenses: Characterization of Optical and Surface Properties of YAG Shots

Analysis of YAG Laser-Induced Damage in Intraocular Lenses: Characterization of Optical and Surface Properties of YAG Shots

Quantitative evaluation of microvacuole formation in five intraocular lens models made of different hydrophobic materials

Augmented cellular uptake and homologous targeting of exosome-based drug loaded IOL for posterior capsular opacification prevention and biosafety improvement

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