Posterior cingulate metabolic changes occur in Parkinson's disease patients without dementia

White Matter Involvement in Idiopathic Parkinson Disease: A Diffusion Tensor Imaging Study

“…24,25 Metabolic abnormalities in the posterior cingulate regions have also been reported. 35 In our study, although the FA was not significantly reduced, the MD was significantly increased; in a previous study that considered FA only, alterations were found in the rostral and anterior cingulate regions. 10 Diffusional parameters of the corticospinal tract were found to be unaltered, in agreement with a previous DTI study and with results from transcranial magnetic stimulation.…”

White Matter Alteration of the Cingulum in Parkinson Disease with and without Dementia: Evaluation by Diffusion Tensor Tract–Specific Analysis

“…Atrophy in the limbic and paralimbic regions occurs in patients with PD without dementia, though less markedly so than in patients with PDD. 29,30 Metabolic abnormalities in the posterior cingulate regions 31,32 and cerebral blood flow reduction in the anterior cingulate cortex 33,34 have been reported in patients with PDD. A reduction in cerebral blood flow in the posterior cingulate cortex has also been reported in PDD.…”

Neuroimaging in Parkinson's Disease

“…Proton magnetic resonance spectroscopy of the striatum has provided variable results in PD itself, but this technique may be useful for differentiating between PD and atypical parkinsonian syndromes, such as multiple system atrophy or progressive supranuclear palsy [13][14][15][16], and there may also be changes in the posterior cingulate [17] and presupplementary motor area cortex [18]. Phosphorus spectroscopy may also reveal changes that appear to differ between PD and multiple system atrophy [19,20].…”