Posterior corneal elevation and back difference corneal elevation in diagnosing forme fruste keratoconus in the fellow eyes of unilateral keratoconus patients

Müftüoğlu, Orkun; Ayar, Orhan; Özülken, Kemal; Özyol, Erhan; Akıncı, Arsen

doi:10.1016/j.jcrs.2013.03.023

Cited by 123 publications

(98 citation statements)

References 20 publications

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“…The resulting “enhanced BFS” is supposed to approximate a normal cornea closely, making subtle elevations more pronounced and possibly aiding in detection of early or subclinical keratoconus. Various indices in normal eyes, keratoconus suspects, as well as established keratoconus have been measured, although definite superiority over earlier devices is yet to be proven 38–43. Recent interest has focused on characterization of aberrometry profiles as well as understanding of corneal biomechanics in keratoconus using instruments such as the Ocular Response Analyzer (Reichert Inc, Depew, NY, USA).…”

Section: Imagingmentioning

confidence: 99%

Keratoconus: current perspectives

Vazirani

Basu²

2013

OPTH

106

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Keratoconus is characterized by progressive corneal protrusion and thinning, leading to irregular astigmatism and impairment in visual function. The etiology and pathogenesis of the condition are not fully understood. However, significant strides have been made in early clinical detection of the disease, as well as towards providing optimal optical and surgical correction for improving the quality of vision in affected patients. The past two decades, in particular, have seen exciting new developments promising to alter the natural history of keratoconus in a favorable way for the first time. This comprehensive review focuses on analyzing the role of advanced imaging techniques in the diagnosis and treatment of keratoconus and evaluating the evidence supporting or refuting the efficacy of therapeutic advances for keratoconus, such as newer contact lens designs, collagen crosslinking, deep anterior lamellar keratoplasty, intracorneal ring segments, photorefractive keratectomy, and phakic intraocular lenses.

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Section: Imagingmentioning

confidence: 99%

Keratoconus: current perspectives

Vazirani

Basu²

2013

OPTH

106

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“…1 Assessing the corneal curvature, corneal thickness, and corneal surface topography patterns and elevation readings are integral parts of a patient's workup. 2,3 Among various indices, keratometry has more applications in diagnosing and grading the disease, tracking disease progression, and planning treatment and patient follow-up. 2,4,5 Keratoconus patients usually have periodic examinations to determine the progression of the disease or the effect of treatment after surgery.…”

mentioning

confidence: 99%

Effect of keratoconus grades on repeatability of keratometry readings: Comparison of 5 devices

Hashemi

Yekta

Khabazkhoob

2015

Journal of Cataract and Refractive Surgery

100

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“…For example, Muftuoglu et al 12 reported approximately 70% sensitivity for a range of different parameters between normal and fellow eyes of patients with keratoconus. However, the results of the current study were in agreement with those reported by Bae et al, 11 who found no difference in the BAD-D or ART-Max values between normal and topographically normal fellow eyes of patients with keratoconus.…”

Section: Discussionmentioning

confidence: 99%

Detection of Keratoconus in Clinically and Algorithmically Topographically Normal Fellow Eyes Using Epithelial Thickness Analysis

Reinstein¹,

Archer²,

Urs³

et al. 2015

J Refract Surg

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PURPOSE To assess the effectiveness of a keratoconus-detection algorithm derived from Artemis very high-frequency (VHF) digital ultrasound (ArcScan Inc., Morrison, CO) epithelial thickness maps in the fellow eye from a series of patients with unilateral keratoconus. METHODS The study included 10 patients with moderate to advanced keratoconus in one eye but a clinically and algorithmically topographically normal fellow eye. VHF digital ultrasound epithelial thickness data were acquired and a previously developed classification model was applied for identification of keratoconus to the clinically normal fellow eyes. Pentacam (Oculus Optikgeräte, Wetzlar, Germany) Belin-Ambrósio Display (BAD) data (5 of 10 eyes), and Orbscan (Bausch & Lomb, Rochester, NY) SCORE data (9 of 10 eyes) were also evaluated. RESULTS Five of the 10 fellow eyes were classified as keratoconic by the VHF digital ultrasound epithelium model. Five of 9 fellow eyes were classified as keratoconic by the SCORE model. For the 5 fellow eyes with Pentacam and VHF digital ultrasound data, one was classified as keratoconic by the VHF digital ultrasound model, one (different) eye by a combined VHF digital ultrasound and Pentacam model, and none by BAD-D alone. CONCLUSIONS Under the assumption that keratoconus is a bilateral but asymmetric disease, half of the ‘normal’ fellow eyes could be found to have keratoconus using epithelial thickness maps. The Orbscan SCORE or the combination of topographic BAD criteria with epithelial maps did not perform better.

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Posterior corneal elevation and back difference corneal elevation in diagnosing forme fruste keratoconus in the fellow eyes of unilateral keratoconus patients

Abstract: Back difference elevation was better than posterior elevation in diagnosing forme fruste keratoconus. However, as sole parameters, both had limited sensitivity and specificity to differentiate between forme fruste keratoconus eyes and normal control eyes.

Cited by 123 publications

References 20 publications

Keratoconus: current perspectives

Keratoconus: current perspectives

Effect of keratoconus grades on repeatability of keratometry readings: Comparison of 5 devices

Detection of Keratoconus in Clinically and Algorithmically Topographically Normal Fellow Eyes Using Epithelial Thickness Analysis

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