Posterior diaphragm agenesis: When liver simulates lungs

Brik, Maia; Santacruz, B.; Bancalari, Eugenia

doi:10.3109/01443615.2013.876393

Cited by 1 publication

(1 citation statement)

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“…The molecular mechanisms regulating myocardial fibrosis are complex and as yet incompletely defined. Increasing evidence suggests that TGF- β 1 signaling pathways play an important role in collagen synthesis [ 40 ]. It has been shown that H 2 S regulates the TGF- β 1 pathway in multiple cell lines and tissues.…”

Section: Discussionmentioning

confidence: 99%

Hydrogen Sulfide Donor GYY4137 Protects against Myocardial Fibrosis

Meng

Zhu

Xiao

et al. 2015

Oxidative Medicine and Cellular Longevity

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Hydrogen sulfide (H2S) is a gasotransmitter which regulates multiple cardiovascular functions. However, the precise roles of H2S in modulating myocardial fibrosis in vivo and cardiac fibroblast proliferation in vitro remain unclear. We investigated the effect of GYY4137, a slow-releasing H2S donor, on myocardial fibrosis. Spontaneously hypertensive rats (SHR) were administrated with GYY4137 by intraperitoneal injection daily for 4 weeks. GYY4137 decreased systolic blood pressure and inhibited myocardial fibrosis in SHR as evidenced by improved cardiac collagen volume fraction (CVF) in the left ventricle (LV), ratio of perivascular collagen area (PVCA) to lumen area (LA) in perivascular regions, reduced hydroxyproline concentration, collagen I and III mRNA expression, and cross-linked collagen. GYY4137 also inhibited angiotensin II- (Ang II-) induced neonatal rat cardiac fibroblast proliferation, reduced the number of fibroblasts in S phase, decreased collagen I and III mRNA expression and protein synthesis, attenuated oxidative stress, and suppressed α-smooth muscle actin (α-SMA), transforming growth factor-β1 (TGF-β1) expression as well as Smad2 phosphorylation. These results indicate that GYY4137 improves myocardial fibrosis perhaps by a mechanism involving inhibition of oxidative stress, blockade of the TGF-β1/Smad2 signaling pathway, and decrease in α-SMA expression in cardiac fibroblasts.

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Section: Discussionmentioning

confidence: 99%