Posterior Fossa Dimensions of Chiari Malformation Patients Compared with Normal Subjects: Systematic Review and Meta-Analysis

Botelho, Ricardo Vieira; Heringer, Lindolfo Carlos; Botelho, Pedro B; Lopes, Rosimary Amorim; Waisberg, Jaques

doi:10.1016/j.wneu.2020.02.182

Cited by 19 publications

(11 citation statements)

References 20 publications

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“…The theory of a developmentally reduced PCF is not applicable in all CMI cases. Therefore, the conclusions from different studies have varied considerably [2,5,11,19,[22][23][24][25][26][27][28]. Most studies have supported a smaller PCF in adult CMI [5,11,[23][24][25][26], while others reported no difference [19,27,28].…”

Section: Discussionmentioning

confidence: 99%

“…Each of these two clinical entities can be present individually, but they frequently occur synchronously [1,4,9,10]. The term "CMI" was used in previous studies, without excluding BIassociated cases, which limits our knowledge regarding the pathogenesis of the underlying CMI [11]. Goel divided BI into two groups, based on the presence (group A) or absence (group B) of the instability of the atlantoaxial region, as demonstrated by an abnormal increase in the atlanto-dental interval [12] (Fig.…”

Section: Introductionmentioning

confidence: 99%

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Morphometric and volumetric analysis of the posterior cranial fossa in adult Chiari malformation type I with and without group B basilar invagination

Xia¹,

Xia²,

Tang³

et al. 2022

J. Integr. Neurosci.

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Background:The frequent association of basilar invagination (BI) makes the understanding of the pathogenesis of Chiari malformation type I (CMI) difficult. The influence of group B type of BI (the BI without obvious atlantoaxial instability) on the skeletal morphology has not been thoroughly studied. The objective of this study is to evaluate the skeletal alterations in the posterior cranial fossa (PCF) of adult CMI cases with and without group B BI. Methods: Fifty-four adult CMI without BI cases (CMI-only group) and 30 adult CMI with group B BI cases (CMI-BI group) were retrospectively studied. Fifty-six adult patients with unruptured intracranial aneurysms were included as the controls. Several linear and angular variables, and the bony volume of the PCF were analyzed based on thin-slice computed tomography data. Results: Morphological analysis revealed a significant difference in several variables from controls compared to CMI-only, and CMI-BI patients. The clivus and occipital bone, shortened and elevated in CMI-only patients, were further flattened in BI-associated CMI patients. Furthermore, although out of the scope for the diagnostic threshold of BI, the CMI-only cases also had a tendency to form BI. The association of BI modified several variables, without further reducing the bony PCF volume. Conclusions: These findings indicate that the variables associated with group B BI tend to be a continuum of the same pathological abnormalities that originate from the same pathological alterations in CMI patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Morphometric and volumetric analysis of the posterior cranial fossa in adult Chiari malformation type I with and without group B basilar invagination

Xia¹,

Xia²,

Tang³

et al. 2022

J. Integr. Neurosci.

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show abstract

“…The volume of the posterior fossa, as a result, is reduced. 12,13 The structures of the posterior fossa are formed from centers originating from the para-axial mesoderm, from the foramen magnum, up to the spheno-occipital synchondrosis (SOS). Above this synchondrosis, the structures at the base of the skull, derived from the prechordal plate, originate from the neural crest.…”

Section: Discussionmentioning

confidence: 99%

Association between Brachycephaly, Chiari Malformation, and Basilar Invagination

Botelho

Hernandez³

et al. 2021

J Neurol Surg A Cent Eur Neurosurg

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Background There is evidence that Chiari malformation (CM) and basilar invagination (BI) are largely due to disproportion between the content and volume of the posterior fossa. A recent study identified an increased association between brachycephaly and BI. In several types of craniosynostosis, the posterior fossa volume is smaller than normal, and this is more pronounced in coronal synostosis. The aim of this study is to evaluate the association between CM and BI. Methods The cephalic index (CI) measured on magnetic resonance imaging (MRI) from a sample of patients with craniocervical malformation was compared with that of normal subjects. Results The average CI in the craniovertebral junction malformation (CVJM) group was significantly higher in BI patients than in normal subjects. The BI patients also had the highest CI among the whole sample of patients (p = 0.009). Conclusions In this study, BI patients had the highest CI among patients with CVJM and a significantly higher CI than those in the control group. Our data confirm the association between BI and brachycephaly.

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“…Chiari type I is a neurological disease in which, as the volume of the posterior fossa decreases, the cerebellar tonsils pass through the foramen magnum to the subarachnoid space of cervical spine. 1,2 In most cases, when a brain MRI is performed for various reasons, such as the presence of neurological manifestations, it is accidentally detected 3 . In recent years, there have been reports of cognitive deficits such as impaired attention, memory, processing speed, and visuospatial performance related to it 4 .…”

Section: Introductionmentioning

confidence: 99%

Chiari malformation type I with depression and severe psychosis: Case report according to the role of the cerebellum in cognition and emotion

Badrfam

Naghavi

Noroozıan

et al. 2021

Clinical Case Reports

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Posterior Fossa Dimensions of Chiari Malformation Patients Compared with Normal Subjects: Systematic Review and Meta-Analysis

Cited by 19 publications

References 20 publications

Morphometric and volumetric analysis of the posterior cranial fossa in adult Chiari malformation type I with and without group B basilar invagination

Morphometric and volumetric analysis of the posterior cranial fossa in adult Chiari malformation type I with and without group B basilar invagination

Association between Brachycephaly, Chiari Malformation, and Basilar Invagination

Chiari malformation type I with depression and severe psychosis: Case report according to the role of the cerebellum in cognition and emotion

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