Posterior mediastinal ganglioneuroblastoma in an adolescent: A case report and review

Sekiguchi, Nodoka; Noguchi, Takuro; Fukushima, Toshirou; Kobayashi, Takashi; Ozawa, Takesumi; Sato, Yoshinori; Takeda, Teiji; Yoshida, Kazuo; Koizumi, Tomonobu

doi:10.1111/1759-7714.13277

Cited by 7 publications

(9 citation statements)

References 20 publications

(56 reference statements)

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“…Mediastinal ganglioneuroblastomas preferentially develop in children younger than 10 years of age, without a sex predominance. It arises mostly in the posterior mediastinum, [242][243][244] and rarely occurs in the anterior mediastinum. 245 Ganglioneuroblastomatous differentiation has been reported in thymomas.…”

Section: Peripheral Neuroblastic Tumors (Sympathetic Paraganglia Tumors)mentioning

confidence: 99%

Mesenchymal Tumors of the Mediastinum: An Update on Diagnostic Approach

Choi¹,

Ro²

2021

Advances in Anatomic Pathology

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Mesenchymal tumors of the mediastinum are a heterogenous group of rare tumors with divergent lineages. Mediastinal mesenchymal tumors are diagnostically challenging due to their diversity and morphologic overlap with nonmesenchymal lesions arising in the mediastinum. Accurate histologic diagnosis is critical for appropriate patient management and prognostication. Many mediastinal mesenchymal tumors affect distinct age groups or occur at specific mediastinal compartments. Neurogenic tumors, liposarcoma, solitary fibrous tumor, and synovial sarcoma are common mesenchymal tumors in the mediastinum. Herein, we provide an update on the diagnostic approach to mediastinal mesenchymal tumors and a review of the histologic features and differential diagnosis of common benign and malignant mesenchymal tumors of the mediastinum.

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Section: Peripheral Neuroblastic Tumors (Sympathetic Paraganglia Tumors)mentioning

confidence: 99%

Mesenchymal Tumors of the Mediastinum: An Update on Diagnostic Approach

Choi¹,

Ro²

2021

Advances in Anatomic Pathology

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“…GNBs contain both mature gangliocytes and immature neuroblasts and are composed of two subgroups, nodular-GNBs (stroma poor) and intermixed-GNBs (stroma rich) [ 1 ]. The majority of GNB cases arise by 10 years of age and have a median diagnosis of 22 months, with less than 50 cases of GNBs in adults being reported in the literature [ 8 , 9 ]. To the authors’ best knowledge, only 21 cases of GNBs arising in the adrenal glands of adults have been reported.…”

Section: Introductionmentioning

confidence: 99%

Adrenal Ganglioneuroblastoma of Adult Onset: Literature Review

Stevens¹,

Malone²,

Dufrene³

et al. 2023

Cureus

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Ganglioneuroblastomas (GNBs) are a rare subtype of neoplastic tumors that arise from the autonomic nervous system and contain both mature gangliocytes and immature neuroblasts. The primary age group affected by GNBs is the pediatric population, with less than 50 cases of adult GNBs existing in the literature. To the authors' best knowledge, only 21 cases of GNBs arising in the adrenal glands of adults have been reported. Herein we present a literature review examining the symptoms, treatment type, age, and sex of adults, and the presence of tumor metastases and calcification from the 21 cases reported in the literature.

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“…However, the “favorable histology” has not been supported by anecdotal instances of ganglioneuroblastomas with violent behavior that have been published. Particularly in the context of metastatic disease, little is known about the molecular characteristics, clinical prognosis, and behavior of primary ganglioneuroblastoma 2 . Hence, it may be challenging to diagnose this malignancy amidst an atypical presentation.…”

Section: Introductionmentioning

confidence: 99%

“…Particularly in the context of metastatic disease, little is known about the molecular characteristics, clinical prognosis, and behavior of primary ganglioneuroblastoma. 2 Hence, it may be challenging to diagnose this malignancy amidst an atypical presentation. We present the case of a 4-year-old boy who was diagnosed with ganglioneuroblastoma on histopathological examination.…”

Section: Introductionmentioning

confidence: 99%

A needle in the haystack: An unusual case presentation of ganglioneuroblastoma at a tertiary care center in Coastal Karnataka

Radhakrishnan,

Rao,

Lashkari

et al. 2023

Clinical Case Reports

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Key Clinical MessageThis case report highlights the importance of recognizing and accurately diagnosing ganglioneuroblastoma, an uncommon variant of neuroblastic tumors in children. Ganglioneuroblastomas have diverse clinical and morphological presentations, and histopathological examination is paramount in guiding treatment decisions, especially in cases with ambiguous symptoms. Early detection is crucial, as the prognosis varies significantly based on the subtype and the presence of metastatic disease. Clinicians should maintain a high index of suspicion and utilize radiological examinations to promptly identify and treat these tumors.AbstractChildren are frequently affected by neuroblastic tumors, which grow from the sympathoadrenal lineage of the neural crest during its development. However, intermixed ganglioneuroblastomas are far less common within the same tumor spectrum, the diagnosis of which could become challenging amidst an unusual presentation. In our case report, we present a 4‐year‐old boy who had complaints of fever and difficulty in walking, with a supra‐renal mass on ultrasound, which was diagnosed as ganglioneuroblastoma‐intermixed type on histopathological examination. This report aims to contribute to the understanding of the diverse clinical and morphological spectrum of ganglioneuroblastomas and the importance of multidisciplinary collaboration and histopathological examination to enhance decision‐making in such ambiguous scenarios.

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Posterior mediastinal ganglioneuroblastoma in an adolescent: A case report and review

Cited by 7 publications

References 20 publications

Mesenchymal Tumors of the Mediastinum: An Update on Diagnostic Approach

Mesenchymal Tumors of the Mediastinum: An Update on Diagnostic Approach

Adrenal Ganglioneuroblastoma of Adult Onset: Literature Review

A needle in the haystack: An unusual case presentation of ganglioneuroblastoma at a tertiary care center in Coastal Karnataka

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