Posterior ocular manifestations following BNT162b2 mRNA COVID-19 vaccine: a case series

Pillar, Shani; Weinberg, Tsafrir; Amer, Radgonde

doi:10.1007/s10792-022-02565-2

Cited by 8 publications

(3 citation statements)

References 32 publications

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“…Notably, our study's predominant subtype of uveitis observed was anterior uveitis, representing 56% of cases. Furthermore, another study also reported scleritis as a common ocular complication following the COVID-19 vaccination, corroborating our findings [28].…”

Section: Discussionsupporting

confidence: 92%

Ocular Complications after COVID-19 Vaccination: A Systematic Review

Hurissi,

Abuallut,

Dibaji

et al. 2024

Medicina

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Background and Objectives: The COVID-19 pandemic affects various populations worldwide. The discovery of vaccinations was necessary for the prevention and elimination of the disease. Despite the high importance of these vaccinations, they may cause some complications, such as ocular complications. This study aims to draw attention to the possible complications of the vaccination and highlight its importance. Materials and Methods: Systematic review of the literature from January 2021 to January 2023. A total of 20 published articles were included and reported cases of ocular complications in patients who received COVID-19 vaccines. Results: A total of 243 patients with verified ocular complications following the COVID-19 vaccination were included, ranging in age from 18 to 84 years. The most common ocular complications reported in the current study were ocular inflammatory complications, which represented 47.3%, followed by optic neuritis (24.3%). Retinal artery occlusion, retinal vein occlusion, acute macular neuroretinopathy, and paracentral acute middle maculopathy represented 10.7%. Herpetic ocular infections and herpetic eye disease (14%). Nearly half (42%) of the patients with ocular problems received the Pfizer-BioNTech vaccination. Conclusions: Despite the high importance of the COVID-19 vaccination, it was found that it is associated with the occurrence of some ocular complications. Future projects should come with more extensive prospective studies to further elucidate the underlying mechanisms and risk factors associated with ocular complications following COVID-19 vaccination, thereby enhancing our understanding and guiding appropriate management strategies.

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Section: Discussionsupporting

confidence: 92%

Ocular Complications after COVID-19 Vaccination: A Systematic Review

Hurissi,

Abuallut,

Dibaji

et al. 2024

Medicina

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“…19 However, there continue to be reports of other ocular inflammatory events, such as scleritis and optic neuritis, following COVID-19 vaccination. [20][21][22][23] The Medicines and Healthcare products Regulatory Agency (MHRA), serving as the governmental entity responsible for ensuring the safety of medicinal provisions and administration within the UK, operates under the auspices of the Department of Health and Social Care.…”

Section: Introductionmentioning

confidence: 99%

Ocular inflammatory events following COVID-19 vaccination: reporting of suspected adverse drug reactions to regulatory authorities in the UK

Testi,

Soomro,

Pavesio

et al. 2023

Br J Ophthalmol

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Background/aimsThe UK Medicines and Healthcare products Regulatory Agency (MHRA) has published suspected adverse drug reactions to vaccines against COVID-19. Ocular inflammatory events following COVID-19 vaccination have been reported worldwide.MethodsWe analysed MHRA data on spontaneous reports of suspected ocular inflammatory events following COVID-19 vaccination between January 2021 and September 2022.ResultsThe MHRA received 300 UK spontaneous suspected reports of ocular inflammatory events following COVID-19 vaccination, with a calculated prevalence of 6.6 events per 1 000 000 vaccinated individuals. Anterior uveitis was the most common phenotype (58.3%), followed by optic neuritis in 39.3%. Median number of days between vaccination and onset was 8 days. Resolution of the event was seen in 52.3%.ConclusionOcular inflammatory events following COVID-19 vaccination have a very rare prevalence in the UK. There is no increase in the reporting rate of uveitis, optic neuritis and scleritis following COVID-19 vaccination when compared with the range of incidence in the UK population. The Yellow Card System represents a vital instrument within the domain of pharmacovigilance, empowering patients and healthcare professionals to contribute to the ongoing monitoring of medication safety.

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“…Much of the literature discloses infective herpetic reactivations in the course of COVID-19 [ 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ]; surprisingly, they have also been reported after COVID-19 vaccination, based on nucleoside-modified messenger RNAs (modRNAs) and adenoviral vectors [ 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 ]. In addition, HHV5, alias Epstein–Barr virus (EBV), and HHV8, alias Kaposi’s sarcoma-associated herpes virus, are two notorious oncoviruses.…”

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confidence: 99%