Posterior Oropharyngeal Ulcers in a Neonate

Hartsell, Angela; Nagappan, Suresh

doi:10.1542/neo.13-11-e687

Cited by 4 publications

(5 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As far as the authors are aware, except for the study by Nebgen et al, 1 most reports of Bednar's aphthae have been case reports [4][5][6][7][8][9][10] or case series. 11 Among reports from Asia, a study by Seung-Woo, who has reported the largest number of cases (n = 16), 11 although they did not perform intergroup comparisons.…”

Section: O R I G I N a L A R T I C L E Incidence And Clinical Risk Fa...mentioning

confidence: 99%

Incidence and clinical risk factors of Bednar's aphthae in Japanese newborns

Narukama,

Takahashi,

Arimitsu

et al. 2023

Pediatrics International

View full text Add to dashboard Cite

BackgroundThe etiology of Bednar's aphthae remains unclear. Our aim was to investigate the incidence of, and factors associated with, Bednar's aphthae in a Japanese newborn cohort.MethodsA retrospective cross‐sectional study was conducted on neonates discharged from the well‐baby nursery at Saitama City Hospital, Japan. The principal investigator carefully examined each neonate's oral cavity, up to and including the pharynx, with a light‐emitting diode (LED) headlight to determine the presence of Bednar's aphthae. Maternal and neonatal clinical characteristics were first compared between neonates with and those without Bednar's aphthae by univariate analysis. Variables with significant inter‐group differences upon univariate analysis were entered into a multivariable logistic‐regression model.ResultsThis study enrolled 1996 infants. We observed Bednar's aphthae in 9.3% of the Japanese newborn infants who were included. When restricted to infants who were born via vaginal delivery, 13.2% of them had aphthae. Multivariable logistic regression analysis identified vaginal delivery (odds ratio = 6.19, p < 0.0001) in Model 1, and vaginal delivery (odds ratio = 6.73, p < 0.0001) and birth weight (odds ratio = 0.9995, p = 0.034) in Model 2 as independent risk factors for the disease.ConclusionThis is the first report of the prevalence of Bednar's aphthae among Japanese neonates. Vaginal delivery was identified as the strongest risk factor. Although confounding between mode of delivery and mechanical stimuli associated with sucking was not found in this study, the findings pave the way for a better understanding of the etiology of Bednar's aphthae.

show abstract

Section: O R I G I N a L A R T I C L E Incidence And Clinical Risk Fa...mentioning

confidence: 99%

Incidence and clinical risk factors of Bednar's aphthae in Japanese newborns

Narukama,

Takahashi,

Arimitsu

et al. 2023

Pediatrics International

View full text Add to dashboard Cite

show abstract

“…In patients with Bednar's aphthae, a specific intervention is not necessary; the aphthae regress spontaneously. Although the pathophysiology of Bednar's aphthae remains unknown, mechanical pressure caused directly by wiping the infant's mouth or indirectly by a pacifier or bottle nipple has long been proposed as a cause of aphthae . A recently speculated mechanism is an immunological reaction to formula or to the maternal vaginal flora because the lesions are seen more frequently in neonates born vaginally and fed formula …”

mentioning

confidence: 99%

“…One is to swab the lesion and send it for HSV culture or PCR under close observation in an outpatient setting. The other is to start empiric acyclovir in an inpatient setting pending an HSV PCR result if the test result cannot be obtained in a short period of time …”

mentioning

confidence: 99%

“…Although the pathophysiology of Bednar's aphthae remains unknown, mechanical pressure caused directly by wiping the infant's mouth or indirectly by a pacifier or bottle nipple has long been proposed as a cause of aphthae. 1,9 A recently speculated mechanism is an immunological reaction to formula or to the maternal vaginal flora because the lesions are seen more frequently in neonates born vaginally and fed formula. 1 Considering both the propensity to develop severe neonatal HSV infection and the potentially unnecessary work-up in patients with neonatal posterior oropharyngeal ulcers, two approaches have been proposed.…”

mentioning

confidence: 99%

“…The other is to start empiric acyclovir in an inpatient setting pending an HSV PCR result if the test result cannot be obtained in a short period of time. 9 Based on the aforedescribed data, the following information may be helpful for differentiation of Bednar's aphthae from SEM disease caused by HSV: a history of maternal HSV; the mode of delivery; onset and symmetry of oropharyngeal lesions; and the nutritional status of the neonate.…”

mentioning

confidence: 99%

See 2 more Smart Citations