2023
DOI: 10.21203/rs.3.rs-3791891/v1
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Posterior parietal cortex oscillatory activity shapes persistent spatial memory impairments induced by soluble amyloid-β oligomers

Souhail Djebari,
Ana Contreras,
Raquel Jimenez-Herrera
et al.

Abstract: Background: In early stages of Alzheimer's disease (AD), soluble amyloid-β (Aβ) is a key player disrupting neuronal activity and contributing to cognitive decline in advanced stages of the disease. While the hippocampus has been a central focus in prior research due to its susceptibility to Aβ-induced alterations, a comprehensive understanding of early AD pathology requires exploring interconnected brain regions. The posterior parietal cortex (PPC), collaborating closely with the hippocampus and involved in va… Show more

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