Posterior pole analysis and ganglion cell layer measurements in Alzheimer’s disease

Ün, Yasemin; Alpaslan, Funda; Dikmen, Nejla Tükenmez; Sönmez, Murat

doi:10.1080/21548331.2022.2107794

Cited by 4 publications

(3 citation statements)

References 27 publications

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“…Changes to the full retinal thickness (FRT), defined from the ILM to the top of RPE, failed to distinguish between tAD in [56], AD in [69], mild AD in [42,47], MCI in [85], aMCI in [65], EOAD in [90], FTD in [79,80], against HCs. Additionally, when multiple classes were involved in the analysis, the FRT variations were negligible between the three groups (mild AD, moderate AD, HCs) in [76], and between (aMCI, AD, HCs) in [67]. According to [69,92], AD patients had a notable thinning of the GCL and IPL in contrast to HCs.…”

Section: Macula-related Parametersmentioning

confidence: 96%

“…In [87], the foveal macular thickness (MT), inner ring of MT in S, I, T, N quadrants, and only the T sector of the MT outer ring were notably reduced for mild AD comparatively with HCs. [76] studied the total retinal thickness (RT), total GCL thickness, RT and GCL thicknesses in S and I quadrants, as well as splitting the macula into S and I hemispheres with 5 zones each. The 5 RT zones in the S hemisphere were RT-SZ1, RT-SZ2, RT-SZ3, RT-SZ4, and RT-SZ5, whereas in the I hemispheres were RT-IZ1, RT-IZ2, RT-IZ3, RT-IZ4 and RT-IZ5.…”

Section: Macula-related Parametersmentioning

confidence: 99%

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A Systematic Review on Retinal Biomarkers to Diagnose Dementia from OCT/OCTA Images

Ibrahim,

Xie,

Macerollo

et al. 2023

Journal of Alzheimer's Disease Reports

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Background: Traditional methods for diagnosing dementia are costly, time-consuming, and somewhat invasive. Since the retina shares significant anatomical similarities with the brain, retinal abnormalities detected via optical coherence tomography (OCT) and OCT angiography (OCTA) have been studied as a potential non-invasive diagnostic tool for neurodegenerative disorders; however, the most effective retinal changes remain a mystery to be unraveled in this review. Objective: This study aims to explore the relationship between retinal abnormalities in OCT/OCTA images and cognitive decline as well as evaluating biomarkers’ effectiveness in detecting neurodegenerative diseases. Methods: A systematic search was conducted on PubMed, Web of Science, and Scopus until December 2022, resulted in 64 papers using agreed search keywords, and inclusion/exclusion criteria. Results: The superior peripapillary retinal nerve fiber layer (pRNFL) is a trustworthy biomarker to identify most Alzheimer’s disease (AD) cases; however, it is inefficient when dealing with mild AD and mild cognitive impairment (MCI). The global pRNFL (pRNFL-G) is another reliable biomarker to discriminate frontotemporal dementia from mild AD and healthy controls (HCs), moderate AD and MCI from HCs, as well as identifing pathological Aβ42/tau in cognitively healthy individuals. Conversely, pRNFL-G fails to realize mild AD and the progression of AD. The average pRNFL thickness variation is considered a viable biomarker to monitor the progression of AD. Finally, the superior and average pRNFL thicknesses are considered consistent for advanced AD but not for early/mild AD. Conclusions: Retinal changes may indicate dementia, but further research is needed to confirm the most effective biomarkers for early and mild AD.

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Section: Macula-related Parametersmentioning

confidence: 96%

Section: Macula-related Parametersmentioning

confidence: 99%

A Systematic Review on Retinal Biomarkers to Diagnose Dementia from OCT/OCTA Images

Ibrahim,

Xie,

Macerollo

et al. 2023

Journal of Alzheimer's Disease Reports

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show abstract

“…If X and Y are two sets of measurements, Bamber [30] showed that AUROC = The device's embedded segmentation software obtains the thickness of each of the 64 cells and provides the measurements of 9 structures or layers. This study presents data for the most representative layers, namely those of the neural retina, as previous studies have observed that the other layers have no clinical significance in these neurodegenerative pathologies [28]. These layers are the retinal nerve fibre layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL) and outer nuclear layer (ONL; contains cell bodies of rods and cones).…”

Section: Study Of Differences In Aucmentioning

confidence: 97%

Differential Study of Retinal Thicknesses in the Eyes of Alzheimer’s Patients, Multiple Sclerosis Patients and Healthy Subjects

Garcia-Martin,

Jimeno-Huete,

Dongil-Moreno

et al. 2023

Biomedicines

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Multiple sclerosis (MS) and Alzheimer’s disease (AD) cause retinal thinning that is detectable in vivo using optical coherence tomography (OCT). To date, no papers have compared the two diseases in terms of the structural differences they produce in the retina. The purpose of this study is to analyse and compare the neuroretinal structure in MS patients, AD patients and healthy subjects using OCT. Spectral domain OCT was performed on 21 AD patients, 33 MS patients and 19 control subjects using the Posterior Pole protocol. The area under the receiver operating characteristic (AUROC) curve was used to analyse the differences between the cohorts in nine regions of the retinal nerve fibre layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL) and outer nuclear layer (ONL). The main differences between MS and AD are found in the ONL, in practically all the regions analysed (AUROCFOVEAL = 0.80, AUROCPARAFOVEAL = 0.85, AUROCPERIFOVEAL = 0.80, AUROC_PMB = 0.77, AUROCPARAMACULAR = 0.85, AUROCINFERO_NASAL = 0.75, AUROCINFERO_TEMPORAL = 0.83), and in the paramacular zone (AUROCPARAMACULAR = 0.75) and infero-temporal quadrant (AUROCINFERO_TEMPORAL = 0.80) of the GCL. In conclusion, our findings suggest that OCT data analysis could facilitate the differential diagnosis of MS and AD.

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Polar-Net: A Clinical-Friendly Model for Alzheimer’s Disease Detection in OCTA Images

Liu,

Hao,

et al. 2023

Lecture Notes in Computer Science

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Posterior pole analysis and ganglion cell layer measurements in Alzheimer’s disease

Cited by 4 publications

References 27 publications

A Systematic Review on Retinal Biomarkers to Diagnose Dementia from OCT/OCTA Images

A Systematic Review on Retinal Biomarkers to Diagnose Dementia from OCT/OCTA Images

Differential Study of Retinal Thicknesses in the Eyes of Alzheimer’s Patients, Multiple Sclerosis Patients and Healthy Subjects

Polar-Net: A Clinical-Friendly Model for Alzheimer’s Disease Detection in OCTA Images

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