Posterior pole retinal thickness distribution pattern in keratoconus

Fard, Ali; Patel, Sangita P; Sorkhabi, Raana; Salekzamani, Sara; Pezzino, Elena; Nader, Nader D.

doi:10.1007/s10792-020-01464-8

Cited by 7 publications

(6 citation statements)

References 38 publications

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“…Possible interactions between the structural properties of the posterior and anterior segments of the eye have been hypothesized as there are continuous extensions of specific ocular structures that span from the anterior to the posterior segments [10]. Accordingly, it has been reported that posterior pole retinal thicknesses may change with KCN severity [11]. Previous case studies have reported the association and coexistence of KCN with degenerative retinal tissue changes in Ehlers-Danlos syndrome, retinitis pigmentosa, tapetoretinal degeneration, and Leber's congenital amaurosis [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

The link between Keratoconus and posterior segment parameters: An updated, comprehensive review

et al. 2022

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Section: Introductionmentioning

confidence: 99%

The link between Keratoconus and posterior segment parameters: An updated, comprehensive review

et al. 2022

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“…Brautaset et al [32] found no significant difference between the eyes of KC patients and controls in any of the ETDRS sectors. Nevertheless, recent studies have shown that the MT in patients with KC was greater than that in the control group, in contrast to the RNFL thickness [20,21]. Moreover, a direct positive correlation was found between the overall MT and the severity of KC [20].…”

Section: Discussionmentioning

confidence: 83%

“…Nevertheless, recent studies have shown that the MT in patients with KC was greater than that in the control group, in contrast to the RNFL thickness [20,21]. Moreover, a direct positive correlation was found between the overall MT and the severity of KC [20]. Sahebjada et al [21] suggested that the inner and outer MT were influenced at the early stages of KC and progressed towards the central fovea as the stages advanced.…”

Section: Discussionmentioning

confidence: 98%

“…In many cases requiring improvement in visual acuity, an accurate posterior segment evaluation is still needed in KC patients. There are only a few studies about the alteration of RNFL and macular thickness (MT) in patients with KC in the literature 20 , 21 , 22 . In this regard, previous studies have published inconsistent results, and which of the retinal layers is responsible for alteration of the thickness has yet to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Retinal Layer Thicknesses in Patients with Keratoconus Using Retinal Layer Segmentation Analysis

Aydemir

Ozkoyuncu

Bilen

et al. 2022

Klin Monbl Augenheilkd

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Objective To conduct an evaluation of the effects of irregular astigmatism on the retinal nerve fiber layer (RNFL) and the retinal layers observed using spectral-domain optical coherence tomography (SD-OCT) in patients who had keratoconus (KC). Materials and Methods A total of 255 eyes from 255 individuals, comprising 72 eyes of KC patients, 70 eyes of patients with astigmia, and 113 eyes of healthy controls were included in the analysis. RNFL scan maps (comprising global, temporal, superotemporal, inferotemporal, nasal, inferonasal, and superonasal maps) and macular thickness (MT) maps of a standard from the Early Treatment Diabetic Retinopathy Study (ETDRS) grid were assessed. The measurements were segmented automatically using Spectralis software, and included the RNFL, inner and outer plexiform layers (IPL, OPL), inner and outer nuclear layers (INL, ONL), ganglion cell layer, retinal pigment epithelium (RPE) in the central 6-mm ETDRS subfield. Results The RNFL thickness in the KC group was lower when compared with the other two groups; however, statistically significant differences were noted in the global, temporal, superotemporal, and inferotemporal sectors (p < 0.05 for all). All of the central MT parameters showed significant variation among the groups, while a statistically significant decrease was noted in the KC group, except in the inferior outer sector (p = 0.741). In the segmentation analysis, the KC group had the significantly lowest IPL, ONL, RPE, and outer retinal layer (ORL) thickness among the groups (p < 0.05 for each). The astigmatic group was similar to the control group with regard to these parameters (p > 0.05 for each). Conclusion The eyes in the KC group appeared to have a thinner RNFL and MT when compared to those in the astigmatic and control groups. The ORLs, especially the ONL and RPE, were the most affected component of the macula in the KC group.

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“…Other studies have shown reduced retinal thicknesses, both in terms of macular thickness, as well as retinal nerve fiber layer thickness and ganglion cell layer thickness [91,92]. Further studies have reported a higher retinal and macular thickness in KC [93,94]. One study demonstrated an increased thickness of the inner nuclear layer with a reduced thickness of the outer retinal layers [95].…”

Section: Discussionmentioning

confidence: 96%

Reduced Retinal Blood Vessel Densities Measured by Optical Coherence Tomography Angiography in Keratoconus Patients Are Negatively Correlated with Keratoconus Severity

Leclaire,

Storp,

Lahme

et al. 2024

Diagnostics

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Keratoconus (KC) is the most common corneal ectasia. Optical coherence tomography angiography (OCT-A) is a relatively new non-invasive imaging technique that allows the visualization and quantification of retinal and choriocapillary blood vessels. The aim of this study is to assess retinal and choriocapillary vessel density (VD) differences between KC patients and healthy controls and to investigate correlations between VD and KC severity. Fifty-two eyes were included in this exploratory study: twenty-six eyes from 26 KC patients and twenty-six eyes from 26 age- and gender-matched healthy controls. All patients underwent Scheimpflug corneal topography with Pentacam, axis lengths measurement and optical coherence tomography angiography (OCT-A). The thinnest spot in corneal pachymetry, maximum K (Kmax) and KC severity indices from the Belin/Ambrósio enhanced ectasia display (BAD) were also assessed. There was a distinct reduction particularly in the retinal VD of the superficial capillary plexus (SCP). Correlation analyses showed strong and moderate negative correlations between the VD in the macular SCP and BAD KC scores and between the SCP VD and Kmax. There was no difference in retinal thickness between the KC and healthy controls. With this study, further evidence for altered VD measurements by OCT-A in KC patients is given. For the first time, we demonstrated negative correlations between BAD KC scores and retinal blood vessel alterations. A major limitation of the study is the relatively small sample size. Since an artefactual reduction of the quantitative OCT-A measurements due to irregular corneal topography in KC must be assumed, it remains to be investigated whether there are also actual changes in the retinal microcirculation in KC.

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Posterior pole retinal thickness distribution pattern in keratoconus

Cited by 7 publications

References 38 publications

The link between Keratoconus and posterior segment parameters: An updated, comprehensive review

The link between Keratoconus and posterior segment parameters: An updated, comprehensive review

Evaluation of Retinal Layer Thicknesses in Patients with Keratoconus Using Retinal Layer Segmentation Analysis

Reduced Retinal Blood Vessel Densities Measured by Optical Coherence Tomography Angiography in Keratoconus Patients Are Negatively Correlated with Keratoconus Severity

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