FIGURE 1 | Meniscus Repair Impediments. (A) Meniscus tears are often classified based on location, orientation, and severity. Location is usually classified by radial axis (inner, intermediate, outer) and circumferential axis (anterior, body, posterior). (B) Meniscus vascularity penetrates only partially into the meniscal body. (C) Circumferential network disruption (radial tears) lead to loss of residual strain, resulting in altered mechano-sensing and potentially cellular apoptosis. (D) Dense extracellular matrix can obstruct repair by limiting cell migration and matrix remodeling. Methods (e.g., growth factors) can improve migration and loosen matrix. (E) Joint factors that influence meniscal repair include concomitant injuries (e.g., ACl, cartilage), inflammation, and varus/valgus loading.