Posterior scleritis following COVID-19 vaccination or infection simulating uveal melanoma in 8 consecutive patients

Negretti, Guy S.; Zeiger, Jennifer S; Cherkas, Elliot; Shields, Carol L.

doi:10.1038/s41433-023-02656-z

Cited by 2 publications

(1 citation statement)

References 28 publications

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“…19 However, there continue to be reports of other ocular inflammatory events, such as scleritis and optic neuritis, following COVID-19 vaccination. [20][21][22][23] The Medicines and Healthcare products Regulatory Agency (MHRA), serving as the governmental entity responsible for ensuring the safety of medicinal provisions and administration within the UK, operates under the auspices of the Department of Health and Social Care.…”

Section: Introductionmentioning

confidence: 99%

Ocular inflammatory events following COVID-19 vaccination: reporting of suspected adverse drug reactions to regulatory authorities in the UK

Testi,

Soomro,

Pavesio

et al. 2023

Br J Ophthalmol

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Background/aimsThe UK Medicines and Healthcare products Regulatory Agency (MHRA) has published suspected adverse drug reactions to vaccines against COVID-19. Ocular inflammatory events following COVID-19 vaccination have been reported worldwide.MethodsWe analysed MHRA data on spontaneous reports of suspected ocular inflammatory events following COVID-19 vaccination between January 2021 and September 2022.ResultsThe MHRA received 300 UK spontaneous suspected reports of ocular inflammatory events following COVID-19 vaccination, with a calculated prevalence of 6.6 events per 1 000 000 vaccinated individuals. Anterior uveitis was the most common phenotype (58.3%), followed by optic neuritis in 39.3%. Median number of days between vaccination and onset was 8 days. Resolution of the event was seen in 52.3%.ConclusionOcular inflammatory events following COVID-19 vaccination have a very rare prevalence in the UK. There is no increase in the reporting rate of uveitis, optic neuritis and scleritis following COVID-19 vaccination when compared with the range of incidence in the UK population. The Yellow Card System represents a vital instrument within the domain of pharmacovigilance, empowering patients and healthcare professionals to contribute to the ongoing monitoring of medication safety.

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Section: Introductionmentioning

confidence: 99%

Ocular inflammatory events following COVID-19 vaccination: reporting of suspected adverse drug reactions to regulatory authorities in the UK

Testi,

Soomro,

Pavesio

et al. 2023

Br J Ophthalmol

View full text Add to dashboard Cite

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Bilateral Choroidal Folds in Thyroid-Associated Ophthalmopathy Without Compressive Optic Neuropathy: A Case Report

Lin,

Shu,

Chen

et al. 2024

Preprint

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Background This case presents a rare form of thyroid-associated ophthalmopathy with idiopathic choroidal folds, unlinked to optic neuropathy—an unusual finding in thyroid-related eye disease. Instead, bilateral nuclear cataracts and lens dislocation were identified as the primary causes of vision loss, emphasizing the importance of considering multiple, less common contributors in such cases. The decision to begin with cataract surgery exemplifies a tailored, effective approach to multifactorial vision loss, offering insights for cases with overlapping ocular issues. Given recent associations between COVID-19 vaccination and ocular symptoms like choroidal folds and scleritis, posterior scleritis was considered a possible explanation. This underscores the need for further investigation into atypical presentations of thyroid-associated eye disease. Case presentation: A 54-year-old male developed bilateral vision loss and choroidal folds one year following COVID-19 vaccination. Initially diagnosed with thyroid-associated ophthalmopathy, he underwent an adequate course of steroid pulse therapy with no visual improvement. Further assessment revealed bilateral cataracts and lens dislocation. Computed tomography identified mild extraocular muscle thickening but no orbital apex crowding, ruling out compressive optic neuropathy. Lens surgery subsequently restored his vision and normalized his visual fields. However, two months postoperatively, he experienced recurrent blurred vision and restricted movement in the right eye. Magnetic resonance imaging confirmed extraocular muscle enlargement, leading to a diagnosis of compressive optic neuropathy, and tocilizumab therapy was initiated. Following treatment, the patient demonstrated improved vision, reduced muscle thickness, and enhanced motility. Conclusions This case suggests that initial choroidal folds may be due to a combination of vaccine-related side effects and elevated orbital pressure, underscoring the potential for COVID-19 vaccination to cause atypical ocular symptoms.

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Posterior scleritis following COVID-19 vaccination or infection simulating uveal melanoma in 8 consecutive patients

Cited by 2 publications

References 28 publications

Ocular inflammatory events following COVID-19 vaccination: reporting of suspected adverse drug reactions to regulatory authorities in the UK

Ocular inflammatory events following COVID-19 vaccination: reporting of suspected adverse drug reactions to regulatory authorities in the UK

Bilateral Choroidal Folds in Thyroid-Associated Ophthalmopathy Without Compressive Optic Neuropathy: A Case Report

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