Posterior Segment Manifestations of inflammatory Bowel Disease

Ernst, Brett; Lowder, Careen Y.; Meisler, David M.; Gutman, Froncie A.

doi:10.1016/s0161-6420(91)32143-2

Cited by 99 publications

(40 citation statements)

References 15 publications

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“…Nongranulomatous, low-grade, recurrent, acute anterior uveitisis is the most common type of IBD-associated uveitis, however posterior uveitis may also occur with chorioretinitis described in 10% of patients in one case series (23) . Steroid-responsive choroidal infiltrates and scattered patches of choroidal inflammation with overlying serous retinal detachment have all been previously described in IBD patients (24) . Opthalmic complications are associated with active IBD in the majority of cases, but not invariably (25) .…”

Section: Discussionmentioning

confidence: 80%

Measurement and clinical implications of choroidal thickness in patients with inflammatory bowel disease

Önal¹,

Yüksel²,

Bayrakceken³

et al. 2015

Arquivos Brasileiros De Oftalmologia

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Approved by the following research ethics committee: Gazi University Ethics Committee. Number N o 53 -26/01/2015. ABSTRACTPurpose: Ocular inflammation is a frequent extraintestinal manifestation of inflammatory bowel disease (IBD) and may parallel disease activity. In this study, we evaluated the utility of a choroidal thickness measurement in assessing IBD activity. Methods: A total of 62 eyes of 31 patients with IBD [Crohn's disease (CD), n=10 and ulcerative colitis (UC), n=21] and 104 eyes of 52 healthy blood donors were included in this study. Choroidal thickness was measured using enhanced depth imaging optical coherence tomography. The Crohn's disease activity index (CDAI) and the modified Truelove Witts score were used to assess disease activity in CD and UC, respectively. Results: No significant differences in mean subfoveal, nasal 3000 µm, or temporal 3000 µm choroidal thickness measurements (P>0.05 for all) were observed between IBD patients and healthy controls. Age, smoking, CD site of involvement (ileal and ileocolonic involvement), CDAI, CD activity, and UC endoscopic activity index were all found to be significantly correlated with choroidal thickness by univariate analysis (P<0.05). Smoking (P<0.05) and the CD site of involvement (P<0.01) were the only independent parameters associated with increased choroidal thickness at all measurement locations. Conclusions: Choroidal thickness is not a useful marker of disease activity in patients with IBD but may be an indicator of ileal involvement in patients with CD.

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Section: Discussionmentioning

confidence: 80%

Measurement and clinical implications of choroidal thickness in patients with inflammatory bowel disease

Önal¹,

Yüksel²,

Bayrakceken³

et al. 2015

Arquivos Brasileiros De Oftalmologia

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“…Although many of the ocular manifestations are believed to be secondary to the same phenomenon causing the underlying disease, namely immunologic disease that affects both the eyes and the bowel, other factors can be claimed to explain the occurrence of some ocular findings, especially genetic factors. In fact, while the eye manifestations sustained by the first mechanism show the same clinical profile as the bowel disease and in such cases bowel resection also results in an improvement of the ocular findings [20], in the case presented by us, for example, no correlation occurred between bowel and retinal disease. Also Hofley et al [26], in a series of 147 children affected by Crohn’s disease and ulcerative colitis, did not find a relationship between the activity of bowel disease and the presence of ocular inflammation.…”

Section: Discussionmentioning

confidence: 95%

“…In fact, although understanding ocular manifestations of inflammatory bowel disease is difficult since the pathogenesis of the intestinal disorder in unclear, genetic evidence demonstrates that there is an increased incidence of disease in Ashkenazi Jews and first-degree relatives [20]. Further, patients with inflammatory bowel disease have a higher incidence of the HLA-B27 haplotype.…”

Section: Discussionmentioning

confidence: 99%

“…Since that time, the most well recognized ocular complications are iridocyclitis and conjunctivitis. Other associations that have been reported with less frequency include dry eyes, blepharitis, episcleritis, scleritis, scleromalacia perforans, orbital inflammatory disease, keratitis, marginal corneal disease, uveitis, pars planitis, retinitis, central and branch retinal artery occlusions, partial central retinal vein occlusion and optic neuritis [7, 9, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22]. …”

Section: Introductionmentioning

confidence: 99%

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Pattern Dystrophy of the Retinal Pigment Epithelium in Crohn’s Disease

Franceschi¹,

Costagliola²,

Soreca³

et al. 2000

Ophthalmologica

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The authors describe a case of bilateral pattern dystrophy of the retinal pigment epithelium in a man with Crohn’s disease. The patient was examined every 6 months over a follow-up of 30 months. The right eye presented a macroreticular dystrophy while in the left eye a butterfly pattern dystrophy was diagnosed. During the follow-up period the retinal lesion changed; in the right eye the lesion increased in size, while in the left eye the morphology of the lesion passed from the butterfly to Sjögren’s type. This report adds a new ocular manifestation of Crohn’s disease, emphasizing the importance of the ophthalmological follow-up in the recognition of posterior segment complications associated with this inflammatory bowel disease.

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“…As doenças inflamatórias intestinais(DII) têm chamado a atenção da comunidade científica pela multiplicidade de manifestações no trato digestivo e pela sua incidência em ascensão(1,2,3, 4,5,6,7,8). Em nosso meio, pode-se concluir que o mesmo esteja ocorrendo face ao crescente nú-mero de publicações (8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31).…”

Section: Introductionunclassified