Posterior Spinal Cord Stimulation in a Case of Painful Legs and Moving Toes

Raina, Gabriela; Piedimonte, Fabián; Micheli, Federico

doi:10.1159/000107366

Cited by 8 publications

(3 citation statements)

References 25 publications

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“…Interestingly, over the years and in parallel with the growing use of this approach for chronic pain, several reports of the potential therapeutic effects of DCS in improving motor symptoms in patients suffering from various motor disorders, such as dystonia, multiple sclerosis, nonparkinsonian tremor, and painful leg and moving toes syndrome, have appeared in the literature …”

Section: Spinal Cord Stimulationmentioning

confidence: 99%

Electrical stimulation of the dorsal columns of the spinal cord for Parkinson's disease

Yadav

Nicolelis

2017

Mov Disord.

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Spinal cord stimulation has been used for the treatment of chronic pain for decades. In 2009, our laboratory proposed, based on studies in rodents, that electrical stimulation of the dorsal columns of the spinal cord could become an effective treatment for motor symptoms associated with Parkinson's disease (PD). Since our initial report in rodents and a more recent study in primates, several clinical studies have now described beneficial effects of dorsal column stimulation in parkinsonian patients. In primates, we have shown that dorsal column stimulation activates multiple structures along the somatosensory pathway and desynchronizes the pathological cortico-striatal oscillations responsible for the manifestation of PD symptoms. Based on recent evidence, we argue that neurological disorders such as PD can be broadly classified as diseases emerging from abnormal neuronal timing, leading to pathological brain states, and that the spinal cord could be used as a "channel" to transmit therapeutic electrical signals to disrupt these abnormalities. © 2017 International Parkinson and Movement Disorder Society.

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Section: Spinal Cord Stimulationmentioning

confidence: 99%

Electrical stimulation of the dorsal columns of the spinal cord for Parkinson's disease

Yadav

Nicolelis

2017

Mov Disord.

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“…This effect persisted 6 months after the implantation [37]. In another case, a 59-year-old woman with PLMT experienced substantial improvement of her widespread pain and near disappearance of toe movements following dorsal SCS during a 13-month followup period [40]. In contrast, a 75-year-old woman implanted with epidural SCS did not have any beneficial effect on PLMT associated with herpes zoster myelitis [41].…”

Section: Painful Leg and Moving Toesmentioning

confidence: 97%

Spinal Stimulation for Movement Disorders

et al. 2014

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Epidural spinal cord stimulation (SCS) is currently proposed to treat intractable neuropathic pain. Since the 1970s, isolated cases and small cohorts of patients suffering from dystonia, tremor, painful leg and moving toes (PLMT), or Parkinson's disease were also treated with SCS in the context of exploratory clinical studies. Despite the safety profile of SCS observed in these various types of movement disorders, the degree of improvement of abnormal movements following SCS has been heterogeneous among patients and across centers in open-label trials, stressing the need for larger, randomized, double-blind studies. This article provides a comprehensive review of both experimental and clinical studies of SCS application in movement disorders.

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“…84 A particularly exciting new role for spinal cord stimulation has been in the treatment of movement disorders such as dystonia, tremor, multiple sclerosis, Parkinson's disease, and painful legs and moving toes syndrome. [85][86][87][88][89][90][91] Seminal work in 2009 revealed that spinal cord stimulation restored locomotion in both dopamine-depleted and 6-hydroxydopamine lesioned rat models of Parkinson's disease. 86 They hypothesized that spinal cord stimulation disrupts the pathologic, synchronous low-frequency, oscillatory local field potential and neuronal patterns that are characteristic of the dorsolateral striatum and primary motor cortex in Parkinson's disease.…”

Section: Recent Developments: Continued Expansion Of Applications Andmentioning

confidence: 99%

Supraspinal Mechanisms of Spinal Cord Stimulation for Modulation of Pain

et al. 2019

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The field of spinal cord stimulation is expanding rapidly, with new waveform paradigms asserting supraspinal sites of action. The scope of treatment applications is also broadening from chronic pain to include cerebral ischemia, dystonia, tremor, multiple sclerosis, Parkinson disease, neuropsychiatric disorders, memory, addiction, cognitive function, and other neurologic diseases. The role of neurostimulation as an alternative strategy to opioids for chronic pain treatment is under robust discussion in both scientific and public forums. An understanding of the supraspinal mechanisms underlying the beneficial effects of spinal cord stimulation will aid in the appropriate application and development of optimal stimulation strategies for modulating pain signaling pathways. In this review, the authors focus on clinical and preclinical studies that indicate the role of supraspinal mechanisms in spinal cord stimulation–induced pain inhibition, and explore directions for future investigations.

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Posterior Spinal Cord Stimulation in a Case of Painful Legs and Moving Toes

Cited by 8 publications

References 25 publications

Electrical stimulation of the dorsal columns of the spinal cord for Parkinson's disease

Electrical stimulation of the dorsal columns of the spinal cord for Parkinson's disease

Spinal Stimulation for Movement Disorders

Supraspinal Mechanisms of Spinal Cord Stimulation for Modulation of Pain

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