Posterior uveal melanoma. Distribution of the sites of origin and patterns of tumour extent in the ocular fundus

Abstract

The temporal hemisphere posterior to the equator is the preferential area of melanoma occurrence and growth. For larger and more aggressive tumours, there is a shift towards more peripherally located initiation sites.

Occupational exposure to electromagnetic fields and sex-differential risk of uveal melanoma

“…In the previous article,27 exposure to welding was interpreted within the context of exposure to artificial light. The posterior temporal segment of the eye is the most common site of melanoma origin,28 and it is doubtful whether melanocytes in the posterior uvea are reached by significant amounts of UV radiation 3. However, electric welding is also associated with high exposure to EMF 29…”

Topographical distribution of choroidal naevi in the ocular fundus

“…27 With the assumption that naevus cells originate from melanocytes, it is tempting to speculate that there are developmental, site-specific variations between choroidal melanocytes, and that temporally located choroidal naevi have an increased potential of growth and malignant transformation compared with naevi located in the nasal fundus hemisphere. Some earlier studies have failed to show a relationship between the quadrantic location of small choroidal melanocytic lesions and their growth potential.…”

Topography of solitary congenital hypertrophy of the retinal pigment epithelium in the ocular fundus

“…Only patients with records containing detailed descriptions of the size and location of the lesion, confirmed by fundus photographs and/or drawings, were included. Our methods of lesion mapping have been described (Krohn et al. 2008a, 2008b).…”

“…Interestingly, there is a marked difference between the topographical distribution of CHRPEs and choroidal melanocytic lesions. Both choroidal naevi and posterior uveal melanomas are concentrated in the posterior pole, and their density gradually decreases towards the fundus periphery (Krohn et al. 2008a, 2008b).…”