Posterity of nanoscience as lipid nanosystems for Alzheimer's disease regression

Naser, Saleh A.; Singh, Dibyangshee; Preetam, Subham; Kishore, Shristi; Kumar, Lamha; Nandi, Aditya; Simnani, Faizan Zarreen; Choudhury, Anmol; Sinha, Adrija; Mishra, Yogendra Kumar; Suar, Mrutyunjay; Panda, Pritam Kumar; Malik, Sumira; Verma, Suresh K.

doi:10.1016/j.mtbio.2023.100701

Cited by 8 publications

(5 citation statements)

References 174 publications

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“… 79 Despite the denaturation of the protein, the heat treatment also helps the zein protein to form stable NPs. 36 , 53 , 79 Raman analysis also concluded that thermal treatment induced redistribution of amino acid residues on the surface of zein NPs. 79 …”

Section: Characterization Structure and Properties Of Zein Nanoparticlesmentioning

confidence: 93%

“…79 Despite the denaturation of the protein, the heat treatment also helps the zein protein to form stable NPs. 36,53,79 Raman analysis also concluded that thermal treatment induced redistribution of amino acid residues on the surface of zein NPs. 79 pH is an important factor affecting a protein's overall structure and morphology, resulting in conformational changes.…”

Section: Characterization Structure and Properties Of Zein Nanoparticlesmentioning

confidence: 94%

“…Protein accumulation occurs due to the destruction of the secondary and tertiary structure of the protein caused due to high-temperature treatment of the protein . Despite the denaturation of the protein, the heat treatment also helps the zein protein to form stable NPs. ,, Raman analysis also concluded that thermal treatment induced redistribution of amino acid residues on the surface of zein NPs …”

Section: Characterization Structure and Properties Of Zein Nanoparticlesmentioning

confidence: 99%

“…The significance and advantages of zein nanoparticles (NPs) in the realms of anticancer agents and gene therapy are marked by their unique strengths, setting them apart from other nanoparticles. ,− One of the primary advantages is their biocompatibility and biodegradability, derived from zein being a naturally occurring protein in corn. This makes zein NPs less toxic and more acceptable to the human body compared with synthetic nanoparticles, thus reducing the risk of adverse reactions during cancer treatment and gene therapy.…”

Section: Introductionmentioning

confidence: 99%

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Revolutionizing Cancer Treatment: The Promising Horizon of Zein Nanosystems

Preetam,

Duhita Mondal,

Mukerjee

et al. 2024

ACS Biomater. Sci. Eng.

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Various nanomaterials have recently become fascinating tools in cancer diagnostic applications because of their multifunctional and inherent molecular characteristics that support efficient diagnosis and image-guided therapy. Zein nanoparticles are a protein derived from maize. It belongs to the class of prolamins possessing a spherical structure with conformational properties similar to those of conventional globular proteins like ribonuclease and insulin. Zein nanoparticles have gained massive interest over the past couple of years owing to their natural hydrophilicity, ease of functionalization, biodegradability, and biocompatibility, thereby improving oral bioavailability, nanoparticle targeting, and prolonged drug administration. Thus, zein nanoparticles are becoming a promising candidate for precision cancer drug delivery. This review highlights the clinical significance of applying zein nanosystems for cancer theragnostic� moreover, the role of zein nanosystems for cancer drug delivery, anticancer agents, and gene therapy. Finally, the difficulties and potential uses of these NPs in cancer treatment and detection are discussed. This review will pave the way for researchers to develop theranostic strategies for precision medicine utilizing zein nanosystems.

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Section: Characterization Structure and Properties Of Zein Nanoparticlesmentioning

confidence: 93%

“…79 Despite the denaturation of the protein, the heat treatment also helps the zein protein to form stable NPs. 36,53,79 Raman analysis also concluded that thermal treatment induced redistribution of amino acid residues on the surface of zein NPs. 79 pH is an important factor affecting a protein's overall structure and morphology, resulting in conformational changes.…”

Section: Characterization Structure and Properties Of Zein Nanoparticlesmentioning

confidence: 94%

Section: Characterization Structure and Properties Of Zein Nanoparticlesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Revolutionizing Cancer Treatment: The Promising Horizon of Zein Nanosystems

Preetam,

Duhita Mondal,

Mukerjee

et al. 2024

ACS Biomater. Sci. Eng.

Self Cite

View full text Add to dashboard Cite

show abstract

“…The examination of the propulsion methods includes electrical fields and ultrasound. While conventional techniques have significantly contributed to the evolution of MNRs, their limited compatibility with biological (especially in environmental or biomedical 44–50 ) applications restricts their potential. 14,15,32,35,51 Within each category, the review delves into the mechanisms of the considered MNRs, outlining their respective advantages, disadvantages, and highlighting noteworthy contemporary research toward better water reclamation.…”

Section: Introductionmentioning

confidence: 99%

Nano revolution: pioneering the future of water reclamation with micro-/nano-robots

Preetam

2024

Nanoscale Adv.

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Nanomaterials that Aid in the Diagnosis and Treatment of Alzheimer's Disease, Resolving Blood–Brain Barrier Crossing Ability

Song,

Li,

et al. 2024

Advanced Science

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As a form of dementia, Alzheimer's disease (AD) suffers from no efficacious cure, yet AD treatment is still imperative, as it ameliorates the symptoms or prevents it from deteriorating or maintains the current status to the longest extent. The human brain is the most sensitive and complex organ in the body, which is protected by the blood–brain barrier (BBB). This yet induces the difficulty in curing AD as the drugs or nanomaterials that are much inhibited from reaching the lesion site. Thus, BBB crossing capability of drug delivery system remains a significant challenge in the development of neurological therapeutics. Fortunately, nano‐enabled delivery systems possess promising potential to achieve multifunctional diagnostics/therapeutics against various targets of AD owing to their intriguing advantages of nanocarriers, including easy multifunctionalization on surfaces, high surface‐to‐volume ratio with large payloads, and potential ability to cross the BBB, making them capable of conquering the limitations of conventional drug candidates. This review, which focuses on the BBB crossing ability of the multifunctional nanomaterials in AD diagnosis and treatment, will provide an insightful vision that is conducive to the development of AD‐related nanomaterials.

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Posterity of nanoscience as lipid nanosystems for Alzheimer's disease regression

Cited by 8 publications

References 174 publications

Revolutionizing Cancer Treatment: The Promising Horizon of Zein Nanosystems

Revolutionizing Cancer Treatment: The Promising Horizon of Zein Nanosystems

Nano revolution: pioneering the future of water reclamation with micro-/nano-robots

Nanomaterials that Aid in the Diagnosis and Treatment of Alzheimer's Disease, Resolving Blood–Brain Barrier Crossing Ability

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