Postexposure Prophylaxis for Influenza in Pediatric Wards Oseltamivir or Zanamivir After Rapid Antigen Detection

Shinjoh, Masayoshi; Takano, Yoshiko; Takahashi, Tsuyoshi; Hasegawa, Naoki; Iwata, Satoshi; Sugaya, Norio

doi:10.1097/inf.0b013e318260265a

Cited by 18 publications

(23 citation statements)

References 38 publications

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“…4,7 In conventional hospitals, influenza outbreaks are also observed. These outbreaks can be dangerous, especially for immunocompromised patients.…”

Section: Resistant Influenza Virusesmentioning

confidence: 95%

“…When identified quickly, it allows measures for control and treatment to be taken before uncontrolled spread of the virus. 2,7 In France, when an outbreak of respiratory infection is detected in a nursing home, the diagnostic strategy is to use bedside tests for the detection of influenza virus. 12 In summary, the three most recent clinical cases are tested if symptoms began <48 h previously; if any of the tests are positive, specimens from all three patients are sent to the reference laboratory for virus detection by reverse transcriptase-PCR.…”

Section: Strategy For the Use Of Rapid Testsmentioning

confidence: 99%

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Rapid bedside tests for diagnosis, management, and prevention of nosocomial influenza

Bouscambert

Valette

Lina

2015

Journal of Hospital Infection

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“…4,7 In conventional hospitals, influenza outbreaks are also observed. These outbreaks can be dangerous, especially for immunocompromised patients.…”

Section: Resistant Influenza Virusesmentioning

confidence: 95%

Section: Strategy For the Use Of Rapid Testsmentioning

confidence: 99%

Rapid bedside tests for diagnosis, management, and prevention of nosocomial influenza

Bouscambert

Valette

Lina

2015

Journal of Hospital Infection

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“…However, mean increase of body temperature was slight. [4][5][6][7][8][9][11][12][13][14] Therefore, it was very difficult to diagnose influenza infection based on a higher body temperature without the rapid diagnostic kit.…”

Section: Number Of Cases Those Diagnosed In the University Of The Ryumentioning

confidence: 99%

“…1 it is impossible to prevent all nosocomial influenza virus infections. More specifically, the effectiveness of chemoprophylaxis in the hospital setting [4][5][6][7][8][9][10][11][12][13][14][15][16] has not been well established. Chemoprophylaxis for those who have had close contact with index cases may supplement pre-requisite vaccination to control influenza virus infection.…”

Section: Introductionmentioning

confidence: 99%

Prevention of a Nosocomial Infection Caused by Influenza Virus A Using Prophylactic Administration of Oseltamivir: An Observational Study with Review of the Literature

Sunagawa

Fujita

Tomishima

et al. 2015

J of Gen and Family Med

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Influenza virus infection in hospitals is a very important clinical issue. The objective of this study was to describe the effect of oseltamivir in controlling a nosocomial influenza virus infection with an observational study and case report. Intervention was carried out in a ward of the University of the Ryukyus Hospital. Symptomatic staff members were sent home for one week, and the infected inpatients were isolated. In addition, in an episode of influenza infection among the staff members and inpatients, oseltamivir (75 mg once a day for 7 days) was administered to all staff members as well as inpatients who had had close contact with the influenza patients. In the hospital ward, eight staff members (nurses and doctors) and ten hospitalized patients were definitively diagnosed with influenza A viral infection based on results of a rapid diagnostic test. Although a relatively large number of the staff members and inpatients had an influenza virus infection, it was possible that the use of oseltamivir efficiently minimized a nosocomial outbreak. It was very difficult to diagnose influenza A virus infection based on clinical symptoms. It was possible to minimize and end the outbreak immediately by using oseltamivir prophylaxis. With a review of the literature, it is considered that prophylaxis with anti‐influenza drugs are highly recommended in hospital settings.

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“…The virus's ability to persist and replicate in immunocompromised hosts, even after higher dosage regimens, underlines the need for alternative therapy considerations in these populations, as well as the paucity of therapeutic options for these high‐risk groups . It should be emphasized, however, that post‐exposure prophylaxis in specialized settings for individuals at high risk of developing severe influenza has proven its utility in several studies, including one conducted in a pediatric ward in Japan …”

Section: Pandemic Responsementioning

confidence: 99%

Antivirals in the 2009 pandemic – lessons and implications for future strategies

Berera

Zambon

2013

Influenza Resp Viruses

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The World Health Organization's declaration of an imminent swine‐origin influenza A pandemic in April 2009 triggered the global launch of national pandemic preparedness plans. An integral component of pandemic preparedness in many countries was the targeted use of antiviral therapy for containment, disease mitigation, and treatment. The 2009 pandemic marked the first pandemic during which influenza antivirals were available for global use. Although most national pandemic plans included provisions for antiviral treatment, these pre‐determined protocols required frequent updating as more information became available about the virus, and its susceptibility to antiviral agents, the epidemiology of infection, and the population groups that were most susceptible to severe disease. National public health agencies in countries with both plans for use of antivirals and pre‐existing stockpiles, including those in Japan, the United Kingdom, and the United States, operated distinctly different antiviral distribution and treatment programs from one another. In the 3 years following the pandemic, there is still little comparison of the diversity of national antiviral treatment policies and drug distribution mechanisms that were implemented, whether they had any mitigating effects and which might be most efficient. The purpose of this study is to outline roles of antiviral medicines in a pandemic period, provide insights into the diversity of antiviral treatment and distribution policies applied by selected countries between April 2009–July 2010, and to stimulate discussion on whether these policies remain appropriate for implementation in future pandemics.

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Postexposure Prophylaxis for Influenza in Pediatric Wards Oseltamivir or Zanamivir After Rapid Antigen Detection

Abstract: PEP using oseltamivir or zanamivir for unexpected occurrences of nosocomial influenza in pediatric wards is safe and effective. The influenza rapid diagnostic test that we used was helpful for detecting nosocomial influenza in children.

Cited by 18 publications

References 38 publications

Rapid bedside tests for diagnosis, management, and prevention of nosocomial influenza

Rapid bedside tests for diagnosis, management, and prevention of nosocomial influenza

Prevention of a Nosocomial Infection Caused by Influenza Virus A Using Prophylactic Administration of Oseltamivir: An Observational Study with Review of the Literature

Antivirals in the 2009 pandemic – lessons and implications for future strategies

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