Postgastrectomy gastric cancer patients are at high risk for colorectal neoplasia: a case control study

Gweon, Tae‐Geun; Yoon, Kyu-Tae; Kim, Chang‐Hyun; Kim, Jin-Jo

doi:10.5217/ir.2020.00009

Cited by 7 publications

(3 citation statements)

References 30 publications

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“…We did not identify any significant clinical differences in the cohorts with and without advanced colorectal neoplasia that would help further guide screening recommendations. It is important to note that this included similar frequencies of gastric cancer history given reports that patients with gastric cancer are at higher risk of colorectal neoplasia (11).…”

Section: Discussionmentioning

confidence: 87%

Colorectal Neoplasia in CDH1 Pathogenic Variant Carriers: A Multicenter Analysis

et al. 2022

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INTRODUCTION: Germline variants in CDH1 are associated with elevated risks of diffuse gastric cancer and lobular breast cancer. It is uncertain whether there is an increased risk of colorectal neoplasia. METHODS:This was a retrospective analysis of colonoscopy outcomes in patients with germline CDH1 pathogenic/ likely pathogenic variants. RESULTS:Eighty-five patients were included with a mean age of 46.9 years. Initial colonoscopy found adenomatous polyps in 30 patients (35.3%), including advanced adenomas in 9 (10.6%). No colorectal cancers were identified on index or subsequent colonoscopies (when available).DISCUSSION:CDH1 carriers have colorectal neoplasia identified at similar rates as in the general population. Despite potential difficulties after gastrectomy, colorectal cancer screening remains important in this population.

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Section: Discussionmentioning

confidence: 87%

Colorectal Neoplasia in CDH1 Pathogenic Variant Carriers: A Multicenter Analysis

et al. 2022

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“…In 2020, it was estimated that about 10% of global cancer incidence, and about 9.4% of cancer-related deaths, could be attributed to CRC [ 2 ]. Risk factors for CRC include sex, age, race, and genetic factors [ 2 - 6 ]. Exposure to environmental risk factors, such as the shift to a modern lifestyle and a Westernized diet, plays a very important role in the increasing global incidence of CRC [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D and Colorectal Cancer: Current Perspectives and Future Directions

Kim

Lim

et al. 2022

J Cancer Prev

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Vitamin D is considered to be the main mediator of the beneficial effects of sun exposure. In humans, highest expression of Vitamin D receptors is found in the intestinal tract. In addition, 1α,25-dihydroxyvitamin D3 (or calcitriol), the most active Vitamin D metabolite, plays important homeostatic roles in the intestine, particularly calcium absorption. Vitamin D deficiency is defined as a serum 25-hydroxyvitamin D [25(OH)D] level of < 20 ng/mL. Previous studies show that higher circulating 25(OH)D levels are associated with reduced risk of colorectal cancer (CRC) and improved survival. Most research to date has been conducted in animals, specifically mice. Although human studies have a limited number of participants, one study recruiting a large cohort of patients with advanced or metastatic CRC revealed that higher plasma 25(OH)D levels are associated with improved overall and progression-free survival. However, the effects of Vitamin D supplementation on incidence and mortality of CRC remain inconclusive. Although Vitamin D may help to prevent cancer, there is a paucity of research demonstrating conclusively that Vitamin D alters prognosis after chemotherapy. Here, we review the mechanisms by which Vitamin D affects CRC, as well as the results of clinical, epidemiological, and human intervention studies. We also discuss current perspectives and future directions regarding Vitamin D and CRC.

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“…[4] It was also reported that a postgastrectomy gastric cancer patient was a high risk for colorectal neoplasia. [5] But weak evidence exists regarding the relationship between EGN and colorectal adenoma.…”

Section: Introductionmentioning

confidence: 99%

Early gastric neoplasms are significant risk factor for colorectal adenoma: A prospective case-control study

Kim¹,

Lee²,

Baek³

et al. 2022

Medicine

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Although gastric cancer patients have a high incidence and risk of colorectal cancer, evidence is lacking regarding whether early gastric neoplasms (EGNs), such as gastric adenomas and early gastric cancer, are risk factors for colorectal adenoma. This study aimed to investigate the incidence of colorectal adenomas in patients with EGN. This prospective study was conducted between January 2015 and December 2016. Of the 307 patients who underwent gastric endoscopic submucosal dissection for EGN, 110 patients were enrolled in the EGN group, and 110 age- and sex-matched healthy persons from the screening population were included in the control group in a 1:1 ratio. Demographic factors and results of colonoscopy, including quality assessment, were collected, and analyzed. No significant differences in the quality of colonoscopy, including bowel preparation, cecal intubation rate, and withdrawal time between the 2 groups, were observed. The incidence of colorectal adenoma was significantly higher in the EGN group than in the control group (55.5% vs 26.4%, P = .001). Multivariate analysis confirmed that old age (odds ratio: 1.04, 95% confidence interval: 1.01–1.08, P = .005) and a history of EGN (odds ratio: 4.99, 95% confidence interval: 2.60–9.57, P = .001) were independent risk factors for colorectal adenoma. This is the first prospective study to reflect the quality indicator of colonoscopy and confirmed that old age and a history of EGN are significant risk factors for colorectal adenomas. Therefore, more stringent colonoscopy surveillance should be considered in elderly patients with EGN.

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Postgastrectomy gastric cancer patients are at high risk for colorectal neoplasia: a case control study

Cited by 7 publications

References 30 publications

Colorectal Neoplasia in CDH1 Pathogenic Variant Carriers: A Multicenter Analysis

Colorectal Neoplasia in CDH1 Pathogenic Variant Carriers: A Multicenter Analysis

Vitamin D and Colorectal Cancer: Current Perspectives and Future Directions

Early gastric neoplasms are significant risk factor for colorectal adenoma: A prospective case-control study

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