This study attempts to investigate how information literacy skills and attitudes towards e-resources use predict the use of e-resources by health sciences postgraduates in Nigeria. A survey research design using the quantitative approach was employed in the study. Further, a two-stage sampling technique [purposive and non-proportional quota] was used to select a sample of 304 health sciences postgraduates. A structured questionnaire was used to collect data. Descriptive and inferential statistics (standard and hierarchical multiple regression) were used to analyse the study data. The hierarchical multiple regression model was used to ascertain the significance of the predictors of the use of e-resources. The major finding was that the best fitting model for predicting the use of e-resources would be the linear combination of the constant, information literacy skills and attitudes towards e-resources use. The study suggests enhanced and sustained positive attitudes and continuous information literacy skills development programmes in higher institutions to further encourage the use of e-resources by health sciences postgraduates.