Posthysterectomy megavoltage irradiation in the treatment of cervical carcinoma

Perkins, P.L.; Chu, Ann M.; Jose, Baby; Achino, Elizabeth; Tobin, Daniel A.

doi:10.1016/0090-8258(84)90219-1

Cited by 31 publications

(11 citation statements)

References 8 publications

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“…Later reports consistently cited cervical dysplasia as the most common preoperative diagnosis, suggesting that most inappropriate hysterectomies resulted from mismanagement of preinvasive cervical lesions (17,18) .…”

Section: Discussionmentioning

confidence: 99%

Simple hysterectomy in the presence of invasive cervical cancer in Iran

Behtash¹,

Mousavi²,

Mohit³

et al. 2003

International Journal of Gynecological Cancer

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The objective of this study was to determine the reasons leading to an inappropriate simple hysterectomy in the presence of invasive cervical cancer. During 1997–2001, 62 cases of invasive cervical carcinoma that had been treated by simple hysterectomy were referred to the gynecology oncology service in Vali-e-Asr hospital, Tehran, Iran. Five had microinvasive carcinoma. The remaining 57 women had either adenocarcinomas or squamous cell carcinoma (SCC). Medical records were reviewed retrospectively to determine the reasons for inappropriate hysterectomy. Reasons for inappropriate hysterectomy were as follow: lack of preoperative Pap smear (P/S) (29%), deliberate hysterectomy for biopsy-proven cancer (25.8%), negative P/S (6.5%), inadequate evaluation of abnormal P/S (6.5%), failure to perform an indicated conization (3.2%), and emergent operation because of uterine perforation (1.6%). Reasons for inappropriate hysterectomy in the remainder of patients (27.4%) were not found because of lack of sufficient information. Although 45.2% of these patients had complained for vaginal bleeding, only four of them had preoperative endocervical and endometrial sampling. Despite the increasing emphasis on performing cervical cancer screening before hysterectomy, only 18 (29%) referral patients had preoperative P/S. We conclude that by close adherence to the cervical cancer screening guidelines and appropriate evaluation of the presenting symptoms, we may avoid inappropriate management of cervical carcinomas with simple hysterectomy. Many cases of simple hysterectomy in the presence of biopsy-proven squamous cell carcinoma of the cervix necessitates some reconsideration of gynecology oncology postgraduate courses for general gynecologists.

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Section: Discussionmentioning

confidence: 99%

Simple hysterectomy in the presence of invasive cervical cancer in Iran

Behtash¹,

Mousavi²,

Mohit³

et al. 2003

International Journal of Gynecological Cancer

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“…Perkins et al [8] reported good outcomes for 32 patients who received AP/PA whole pelvis irradiation following simple hysterectomy and noted that there were no demonstrable advantages in adding transvaginal brachytherapy. However, vaginal relapse was reported in 50 % (6/12) of their recurrent patients.…”

Section: Discussionmentioning

confidence: 99%

A Retrospective Six Years Analysis of Survival and Late Morbidity of Post-operative Gynaecological Malignancy Treated with External Radiotherapy Followed by Brachytherapy in Medical College & Hospitals, Kolkata

Ghosh

Mitra

et al. 2013

J Obstet Gynecol India

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Background Cervical and endometrial carcinoma incidentally found in the surgical specimen with high risk pathological finding or with gross residual disease. Material and Methods Between 2004 and 2010, 320 cervical and endometrial cancer patients were treated with EBRT and brachytherapy after having undergone total/ subtotal hysterectomy. Sixty patients were lost to followup. Results Median follow-up was 21 months. Endometrial and cervical cancer with a high risk for local recurrence achieved CR 93.8 and 89 %, respectively. 56 % patients experienced CR with residual disease with cervical cancer. Median OS for endometrial and cervical cancer with residual disease was 8.5 and 24 months, respectively. Grade 3 adverse events were 5 and 3.5 % for rectum and bladder, respectively. Conclusion The incorporation of chemotherapy during pelvic radiotherapy followed by HDR interstitial brachytherapy for residual disease is inadequate and improves survival. We are still in learning phase of brachytherapy in post-operative gynaecological malignancy cases; expertise will be developed by practice.

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“…FIGO evreleme sistemine göre erken evre, orta-yüksek riskli endometriyum kanserli hastalarda adjuvan RT'nin lokal yinelemeleri azalttığı bilinmektedir (11)(12)(13)(14)(15). PORTEC çalışmasında 60 yaş üstü, derin miyometrial invazyon gösteren grad 1-2 veya <%50 miyometrial invazyon gösteren grad 3 tümörlü hastalarda TAH+BSO sonrasında adjuvan RT uygulanmasının lokal-bölgesel kontrolu anlamlı arttırdığı gösterilmiştir (16).…”

Section: Endometriyum Kanserinde Brakiterapiunclassified

“…Bu çalışmada erken evre endometriyum kanserinde adjuvan RT'nin yüksek-orta risk grubundaki hastalarda lokal kontrolü arttırdığı gösterilmiştir. Yine Aalders ve arkadaşlarının çalışmasında (Norveç ça-lışması) evre IC, grad 3 hastalar yüksek riskli hastalar olarak seçilmiştir (13 …”

Section: Endometriyum Kanserinde Brakiterapiunclassified

Jinekolojik tümörlerde brakiterapideki güncel gelişmeler: Jinekolojik tümörlerde brakiterapi

Yavaş¹

2014

GenelTipDer

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Posthysterectomy megavoltage irradiation in the treatment of cervical carcinoma

Cited by 31 publications

References 8 publications

Simple hysterectomy in the presence of invasive cervical cancer in Iran

Simple hysterectomy in the presence of invasive cervical cancer in Iran

A Retrospective Six Years Analysis of Survival and Late Morbidity of Post-operative Gynaecological Malignancy Treated with External Radiotherapy Followed by Brachytherapy in Medical College & Hospitals, Kolkata

Jinekolojik tümörlerde brakiterapideki güncel gelişmeler: Jinekolojik tümörlerde brakiterapi

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