Postinfectious Functional Gastrointestinal Disorders in Children: A Multicenter Prospective Study

Pensabene, Licia; Talarico, Valentina; Concolino, Daniela; Ciliberto, Domenico; Campanozzi, Angelo; Gentile, T.; Rutigliano, Vincenzo; Salvatore, S.; Staiano, Annamaria; Lorenzo, Carlo Di; Graziano, Francesca; Palermo, Bianca Virginia; Sanseviero, Mariateresa; Altomare, Federica; Cozza, E; Falvo, Antonella; Marseglia, Antonio; Gatta, Emanuele; Venuto, D. De; Ripepi, A.; Turco, Rosa

doi:10.1016/j.jpeds.2014.12.050

Cited by 49 publications

(23 citation statements)

References 34 publications

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“…It has been shown that the development of CMP-related allergic proctocolitis [ 2 ] in the first months of life might trigger persistent digestive symptoms, particularly IBS. Other sources of inflammation, such as infectious gastroenteritis, may also trigger FGIDs (postinfectious FAPDs, particularly IBS), which can last for months to several years [ 41 , 42 , 96 , 97 , 98 , 99 ]. GI inflammation may also lead to visceral hypersensitivity through increased mucosal membrane permeability to antigens via alteration of tight junctions [ 100 ], increased cytokines release [ 101 ], altered mucosal immune function, microbiota [ 102 ], and receptor sensitivity in the gut mucosa and myenteric plexus.…”

Section: Cow’s Milk Allergy and Functional Gastrointestinal Disordmentioning

confidence: 99%

Cow’s Milk Protein Allergy in Infancy: A Risk Factor for Functional Gastrointestinal Disorders in Children?

et al. 2018

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The role and prevalence of cow’s milk protein allergy (CMA) in functional gastrointestinal disorders remains unclear. The aim of this review is to update knowledge on the relationship between CMA and functional abdominal pain disorders (FAPDs) in children. Cochrane Database and Pubmed were searched from inception using general and specific terms for CMA and functional gastrointestinal disorders. CMA is reported as a predisposing or coexisting factor in a wide range of functional gastrointestinal disorders in infants and children. Pathogenesis of both conditions is complex and multiple mechanisms including dysmotility and hypersensitivity might contribute to the clinical manifestations. Data supporting the possible role of food allergies in the pathogenesis of FAPDs are limited. CMA may predispose to early life inflammation and visceral hypersensitivity, which in turn might manifest as FAPDs. The diagnosis of either CMA or FAPDs and distinction between them is challenging because of nonspecific and overlapping symptoms. Lack of accurate allergy tests in non-IgE (immunoglobulin E) mediated cases is also problematic. Oral food challenge, following an elimination diet, should be performed to diagnose a suspected non-IgE CMA allergy in children with FAPDs. In the management of FAPDs, an elimination diet should be considered for a limited period to verify if the symptoms improve or resolve.

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Section: Cow’s Milk Allergy and Functional Gastrointestinal Disordmentioning

confidence: 99%

Cow’s Milk Protein Allergy in Infancy: A Risk Factor for Functional Gastrointestinal Disorders in Children?

et al. 2018

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“…Functional GI disorders related to post inflammation possibly differ between children and adults. For example, it is still unclear what the mechanisms are by which sometimes acute inflammation secondary to acute gastroenteritis leads to FGIDs, while chronic inflammation for months or years as seen in CD does not trigger FGIDs [ 108 , 109 ].…”

Section: Celiac Disease and Fapdmentioning

confidence: 99%

Gluten and Functional Abdominal Pain Disorders in Children

Llanos-Chea

Fasano

2018

Nutrients

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In children, functional gastrointestinal disorders (FGIDs) are common at all ages. Consumption of certain foods, particularly gluten, is frequently associated with the development and persistence of FGIDs and functional abdominal pain disorders (FAPDs) in adults and children. However, this association is not well defined. Even without a diagnosis of celiac disease (CD), some people avoid gluten or wheat in their diet since it has been shown to trigger mostly gastrointestinal symptoms in certain individuals, especially in children. The incidence of conditions such as non-celiac gluten sensitivity (NCGS) is increasing, particularly in children. On the other hand, CD is a chronic, autoimmune small intestinal enteropathy with symptoms that can sometimes be mimicked by FAPD. It is still unclear if pediatric patients with irritable bowel syndrome (IBS) are more likely to have CD. Abdominal, pain-associated FGID in children with CD does not seem to improve on a gluten-free diet. The threshold for gluten tolerance in patients with NCGS is unknown and varies among subjects. Thus, it is challenging to clearly distinguish between gluten exclusion and improvement of symptoms related solely to functional disorders.

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“…Los desórdenes gastrointestinales funcionales (DGFs) constituyen una de las más frecuentes razones de consulta médica en pediatría 1 . La patogénesis de los DGFs es multifactorial, y la idea de que los agentes ambientales pueden estar envuel-tos en la patogénesis de los DGFs es cada vez más aceptada; siendo, la presencia de los DGFs postinfecciosos ya descrita como una verdadera entidad pediátrica 2,3 .…”

Section: Introductionunclassified

¿El antecedente de dengue está asociado a la presencia de Desórdenes Gastrointestinales Funcionales en Niños?

Velasco-Benítez

Ortíz-Rivera

2019

Infect

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Introducción: La patogénesis de los desórdenes gastrointestinales funcionales (DGFs) es multifactorial.Objetivo: Investigar la prevalencia de DGFs luego del antecedente de dengue.Materiales y métodos: Estudio de prevalencia en niños entre 8-18 años de edad. Se tomaron variables sociodemográficas, clínicas y el antecedente del último año de dengue diagnosticado en urgencias. Se aplicó el Cuestionario para Síntomas Gastrointestinales Pediátricos Roma III en Español para DGFs. El análisis estadístico incluyó el cálculo del OR, con IC95% y Fisher a dos colas, con una p<0.05 significativo.Resultados: Fueron incluidos 4023 niños con edad 11,9±2,3 años y 50,1% masculinos. La prevalencia para presentar al menos 1 DGFs fue 23.0% y del antecedente de haber presentado dengue en el último año del 7,5%; habiendo predominio en escolares entre 8-12 años de edad (OR=1,56 IC95%=1,20-2,04 p=0,0006) y con al menos 1 DGFs (OR=1,98 IC95%=1,53-2,56 p<0,0001). En los niños que por antecedente presentaron dengue en el último año, hubo diferencias significativas cuando tenían padres separados/divorciados.Conclusión: En este grupo de niños, los DGFs son frecuentes, presentándose mayor oportunidad de tener algún DGFs en los escolares entre los 8-12 años de edad cuando se tiene el antecedente de dengue diagnosticado en un servicio de urgencias.

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Postinfectious Functional Gastrointestinal Disorders in Children: A Multicenter Prospective Study

Cited by 49 publications

References 34 publications

Cow’s Milk Protein Allergy in Infancy: A Risk Factor for Functional Gastrointestinal Disorders in Children?

Cow’s Milk Protein Allergy in Infancy: A Risk Factor for Functional Gastrointestinal Disorders in Children?

Gluten and Functional Abdominal Pain Disorders in Children

¿El antecedente de dengue está asociado a la presencia de Desórdenes Gastrointestinales Funcionales en Niños?

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