Postinfectious Irritable Bowel Syndrome After a Food-Borne Outbreak of Acute Gastroenteritis Attributed to a Viral Pathogen

Marshall, John K.; Thabane, Marroon; Borgaonkar, Mark; James, Cindy

doi:10.1016/j.cgh.2006.11.025

Cited by 213 publications

(157 citation statements)

References 20 publications

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“…Encephalopathy [37] was not included because this was only described in case reports. Although irritable bowel syndrome was prospectively identified as a lingering symptom of viral gastroenteritis [38], the attribution of this disease outcome to a norovirus infection is not yet established and needs further investigation. Similarly, the potential of chronic norovirus diarrhoea in immunocompromised individuals requires confirmation before it can be included in our estimates.…”

Section: Discussionmentioning

confidence: 99%

The estimated disease burden of norovirus in The Netherlands

et al. 2012

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SUMMARYNoroviruses are an important cause of acute gastroenteritis in humans. We incorporated new insights gained over the past decade in an updated estimate of the disease burden of (foodborne) norovirus illness in The Netherlands in 2009. The disease outcomes -non-consulting cases, visiting a general practitioner, hospitalization and mortality -and the foodborne proportion were derived from cohort studies, surveillance data and literature. Age-specific incidence estimates were applied to the population age distribution in The Netherlands in 2009. The general population incidence was 3800/100 000 (95 % CI 2670-5460), including 0 . 4 fatal cases/100 000, resulting in 1622/100 000 (95 % CI 966-2650) disability-adjusted life-years in a population of 16 . 5 million. The updated burden of norovirus is over twofold higher than previously estimated, due in particular to the new insights in case-fatality ratios. Results suggest that the burden of norovirus institutional outbreaks is relatively small compared to the burden of community-acquired norovirus infections.

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Section: Discussionmentioning

confidence: 99%

The estimated disease burden of norovirus in The Netherlands

et al. 2012

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“…There is increasing evidence that acute infectious gastroenteritis (GE) can increase the risk of IBS, with several studies demonstrating that a significant number of GE patients develop PI-IBS [1,2,[18][19][20][21][22][23]. Campylobacter, Shigella, Salmonella and Escherichia coli infections as well as viral agents, including norovirus, and parasites have been associated with PI-IBS [5,21,[23][24][25].…”

Section: Introductionmentioning

confidence: 99%

“…Campylobacter, Shigella, Salmonella and Escherichia coli infections as well as viral agents, including norovirus, and parasites have been associated with PI-IBS [5,21,[23][24][25]. It has been hypothesized that exposure to an infectious organism alters gut flora, increases intestinal permeability and triggers chronic inflammation, inducing PI-IBS [3,9,26,27].…”

Section: Introductionmentioning

confidence: 99%

“…Severity of GE (duration of diarrhoea, presence of blood in stools, abdominal cramps, weight loss), younger age and female gender have been associated with increased risk of PI-IBS [21,[28][29][30][31][32][33][34]. Anxiety, depression and major life events have also been identified as potential risk factors with some hypothesizing that these disorders prolong gut inflammation and heighten sensory perception [22,26,28,29,32,[35][36][37].…”

Section: Introductionmentioning

confidence: 99%

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Relative risk of irritable bowel syndrome following acute gastroenteritis and associated risk factors

et al. 2013

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SUMMARYA prospective cohort study using electronic medical records was undertaken to estimate the relative risk (RR) of irritable bowel syndrome (IBS) following acute gastroenteritis (GE) in primary-care patients in The Netherlands and explore risk factors. Patients aged 18-70 years who consulted for GE symptoms from 1998 to 2009, met inclusion/exclusion criteria and had at least 1 year of follow-up data were included. Patients with non-GE consultations, matched by age, gender, consulting practice and time of visit, served as the reference group. At 1 year, 1·2% of GE patients (N = 2428) had been diagnosed with IBS compared to 0·3% of the reference group (N = 2354). GE patients had increased risk of IBS [RR 4·85, 95% confidence interval (CI) 2·02-11·63]. For GE patients, concomitant cramps and history of psycho-social consultations were significantly associated with increased risk. GE patients had increased risk of IBS up to 5 years post-exposure (RR 5·40, 95% CI 2·60-11·24), suggesting there may be other contributing factors.

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“…Several studies have established the causative pathogens of PI-IBS, including Shigella spp., 16,23 pathogenic E. coli, 22 Salmonella spp., 13,18 C. jejuni, 15 G. duodenali, 19 Trichinella britovi, 25 norovirus, 26 or combinations of the preceding pathogens. 14,22 The reported incidence of PI-IBS varies from about 5-30%, 11 and PI-IBS is now a well-recognized consequence of acute infectious gastroenteritis.…”

Section: Discussionmentioning

confidence: 99%

Long-term Clinical Course of Post-infectious Irritable Bowel Syndrome After Shigellosis: A 10-year Follow-up Study

Youn

Kim

Lim

et al. 2016

J Neurogastroenterol Motil

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Background/AimsA limited number of studies are available regarding the long-term natural history of post-infectious irritable bowel syndrome (PI-IBS). We aimed to investigate the long-term clinical course of PI-IBS. MethodsA prospective cohort study was conducted from a 2001 shigellosis outbreak in a Korean hospital with about 2000 employees. A cohort of 124 hospital employees who were infected by Shigella sonnei due to contaminated food in the cafeteria, and 105 sex-and age-matched, non-infected, controls were serially followed for their bowel symptoms by questionnaire surveys for 10 years. ResultsThe Shigella-infected cohort showed significantly higher odds ratio for irritable bowel syndrome (IBS) at 1-year (11.90; 95% CI, 1.49-95.58) and 3-year (3.93; 95% CI, 1.20-12.86) follow-up, compared to their controls. However, corresponding odds ratio for PI-IBS was not significantly increased at 5-year (1.88; 95% CI, 0.64-5.54) and 8-year (1.87; 95% CI, 0.62-5.19) follow-up. At 10-year followup survey, the prevalence of IBS was similar for the Shigella-infected cohort and their controls (23.3% versus 19.7%, P = 0.703). Risk factors which were independently associated with PI-IBS among the Shigella-infected cohort included younger age, previous history of functional bowel disorder, and longer duration of diarrhea at baseline. ConclusionsPatients who were infected by Shigella sonnei experienced significantly increased risk of IBS until 3 years after shigellosis, and modestly increased risk until 8 years, but showed similar risk of IBS with uninfected controls at 10 years post-infection. PI-IBS is quite a chronic disorder, and follows a long-term natural course.

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Postinfectious Irritable Bowel Syndrome After a Food-Borne Outbreak of Acute Gastroenteritis Attributed to a Viral Pathogen

Cited by 213 publications

References 20 publications

The estimated disease burden of norovirus in The Netherlands

The estimated disease burden of norovirus in The Netherlands

Relative risk of irritable bowel syndrome following acute gastroenteritis and associated risk factors

Long-term Clinical Course of Post-infectious Irritable Bowel Syndrome After Shigellosis: A 10-year Follow-up Study

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