“…Although diagnosis of MP infection requires fourfold rising of the serologic titer (17), temporal relationship of MP antibody titer with clinical and radiological changes suggests that the patient's neurologic symptoms are related to MP infection. All other investigations were nonrevealing, and the clinical course of this patient excluded the possibility of mitochondria1 cytopathy or other progressive metabolic disorders.In the literature, neurologic manifestations associated with MP infection include meningitis (2), meningoencephalitis (2,3,7,9,10,14), encephalomyelitis ( 1 3 , psychosis (l), seizures (3,12,14,16), polyradiculitis (2,3,13), acute cerebellar ataxia (3, brain stem dysfunction (4), and myelitis (6,ll). Considering the clinical course, imaging studies, and negative culture studies, the neurologic manifestations of at least some of these patients were believed to be immune or toxin mediated (7,11,14,17) rather than due to direct invasion of the organism.…”