Postinfectious meningoencephalitis complicating Mycoplasma pneumoniae in a child.

Abstract

Dissecting aneurysm of the vertebro-basilar artery. A case report and review of previous cases. Brain Nerve (Tokyo) 1979;31:1211-9.

Reversible parkinsonism and dystonia following probable mycoplasma pneumoniae infection

“…Although diagnosis of MP infection requires fourfold rising of the serologic titer (17), temporal relationship of MP antibody titer with clinical and radiological changes suggests that the patient's neurologic symptoms are related to MP infection. All other investigations were nonrevealing, and the clinical course of this patient excluded the possibility of mitochondria1 cytopathy or other progressive metabolic disorders.In the literature, neurologic manifestations associated with MP infection include meningitis (2), meningoencephalitis (2,3,7,9,10,14), encephalomyelitis ( 1 3 , psychosis (l), seizures (3,12,14,16), polyradiculitis (2,3,13), acute cerebellar ataxia (3, brain stem dysfunction (4), and myelitis (6,ll). Considering the clinical course, imaging studies, and negative culture studies, the neurologic manifestations of at least some of these patients were believed to be immune or toxin mediated (7,11,14,17) rather than due to direct invasion of the organism.…”

Use of corticosteroids in Mycoplasma pneumoniae encephalitis: A case report and review of literature

“…In the CEP study, eighty percent of 84 patients were positive for M. pneumoniae by serology alone [11], and CSF -PCR for M. pneumoniae was rarely positive (2%) [11], The presence of IgM antibodies specific to M. pneumoniae are a reliable determinant of acute infection since they typically appear within 1 wk of the initial infection [39]. It is widely held that immunological sequelae of M. pneumoniae infection account for some of the neurologi-cal complications [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40], which supports the use of corticosteroids in treatment. There are both identified case series and case reports of use of corticosteroids in patients of Mycoplasma pneumonia CNS involvement.…”

“…Since autoimmunity has been suggested as a mechanism of CNS involvement; this has led clinicians to consider the use of corticosteroids for these patients. Its use has been described in case reports and case series and has shown good results [20,[24][25][26][27][28][29][30][31][32][33][34][35]. We report here a severe case of mycoplasma-associated encephalitis that had full recovery with the use of high dose corticosteroids.…”

Acute Disseminated Encephalomyelitis following Pontiac Fever

“…It has also been reported to occur after cryptococcosis [25], malaria [26], and Chlamydia infection [27], and is well known to occur following Mycoplasma infection [21,28,29]. Easterbrook and Smyth [30] report a case of postinfectious encephalomyelitis after atypical pneumonia, in which serology was positive for both Legionella and Mycoplasma.…”