Postintervention monitoring of peripheral arterial disease wound healing using dynamic vascular optical spectroscopy

Abstract

. Significance Due to the persistence of chronic wounds, a second surgical intervention is often necessary for patients with peripheral arterial disease (PAD) within a year of the first intervention. The dynamic vascular optical spectroscopy system (DVOS) may assist physicians in determining patient prognosis only a month after the first surgical intervention. Aim We aim to assess the DVOS utility in characterizing wound healing in PAD patients after endovascular intervention. Approach The DVOS used near-infrared light ( ) to record hemodynamic response to a cuff inflation in 14 PAD patients with lower limb ulcers immediately before, immediately after, and at a first follow-up 3 to 4 weeks after intervention. Ankle-brachial index (ABI) and arterial duplex ultrasound (A-DUS) measurements were obtained when possible. Results The total hemoglobin plateau time differed significantly between patients with ulcers that reduced in size ( ) and patients with ulcers that did not ( ) 3 to 4 weeks after intervention ( ). Data correlated strongly (89% sensitivity, 100% specificity, and ) with long-term wound healing. ABI and A-DUS measurements were not statistically associated with wound healing. Conclusions This pilot study demonstrates the potential of the DVOS to aid physicians in giving accurate long-term wound healing prognoses 1 month after intervention.

Design of a flexible dynamic optical spectroscopic system for monitoring blood oxygenation status in the carotid artery

“…Dynamic vascular optical spectroscopy (DVOS) holds unique promise as a noninvasive modality for evaluating carotid health 12 . By measuring the light reflected from the tissue of interest in response to light sources with known properties and examining the resultant absorption, DVOS can capture valuable data regarding oxygen saturation levels 13,14 . However, traditional optical spectroscopy systems tend to be bulky, expensive and designed for use by specialized personnel in controlled environments like research laboratories or clinics 9 .…”

“…Recently, optical devices are becoming increasingly compact and portable, making them suitable for at-home health monitoring and integration into wearable technologies 15 . While many of these efforts have concentrated on peripheral areas such as the finger or feet, new developments in flexible sensors are enabling the examination of crucial areas such as the carotid arteries 14,16 . In this paper, we introduce a wearable patch system that uses DVOS for noninvasive carotid artery monitoring.…”