Postinterventional homocysteine levels: Failure as a predictive biomarker of in-stent restenosis

Plasma homocysteine level is unrelated to long-term cardiovascular events in patients with previous percutaneous coronary intervention

“…Previous studies have reported that the elevated level of plasma Hcy is associated with a higher incidence of restenosis after percutaneous coronary intervention (PCI), although conflicting results exist [8,9], and that patients with an elevated level of plasma Hcy have an adverse short-term outcome after PCI [10,11]. However, it is unclear whether the plasma Hcy level affects long-term outcomes in patients with previous PCI.…”

Effect of folate on neointima formation and matrix metalloproteinase-9 expression after balloon injury in hyperhomocysteinemic rabbits

“…Hhcy, a widely recognized independent risk factor for atherosclerosis, recently has received much attention for its roles in the tendency of restenosis after angioplasty. However, the current studies that have been published in the peer-reviewed medical literature have not reached a consensus as to whether Hhcy is an independent risk factor responsible for restenosis following vascular intervention [17][18][19] and to whether lowering-Hhcy treatment can reduce the rate of restenosis [19,20]. In this study, we found HHcy exacerbated neointima formation independent of hyperlipoidemia in rabbit aortas after balloon injury and folate supplementation alleviated these changes.…”