Postischemic regulation of central histamine receptors

Lozada, Adrian F.; Munyao, Nzau; Sallmén, Tina; Lintunen, Minnamaija; Leurs, Rob; Lindsberg, Perttu J.; Panula, Pertti

doi:10.1016/j.neuroscience.2005.06.079

Cited by 30 publications

(16 citation statements)

References 50 publications

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“…Our chemical analysis also found that there was no significant difference in the glutamate and GABA level between the rUCCAO and sham group ( Figure S2), although carnosine elevated the level of GABA in the striatum at day 1 and in the cortex and corpus callosum at day 37 after rUCCAO. Moreover, our data suggest that histamine may not be involved in SIVD, because there is no significant difference between WT and HDC-KO mice after rUCCAO, and histidine has no protection against WM lesion and the impairment of learning and memory after rUCCAO, but histamine is found to participate in acute cerebral ischemia from a lot of previous studies [18][19][20]. So, it seems that pathological mechanism of SIVD is so different from the acute cerebral ischemia which causes excitotoxicity because of excessive glutamate release and involves histamine.…”

Section: Discussionmentioning

confidence: 66%

Protective Effect of Carnosine on Subcortical Ischemic Vascular Dementia in Mice

Xiong

Hou

et al. 2012

CNS Neurosci Ther

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Section: Discussionmentioning

confidence: 66%

Protective Effect of Carnosine on Subcortical Ischemic Vascular Dementia in Mice

Xiong

Hou

et al. 2012

CNS Neurosci Ther

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“…However, there is no convincing evidence for the existence of particular amygdalar subareas with low densities in H 1 , H 2 and especially H 3 receptors, although a few studies have reported that these receptors (binding and mRNA expression) are far from being evenly distributed over the amygdalar and hippocampal areas (Drutel et al, 2001;Pillot et al, 2002;Lozada et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Differential effects of histamine H3 receptor inverse agonist thioperamide, given alone or in combination with the N-methyl-d-aspartate receptor antagonist dizocilpine, on reconsolidation and consolidation of a contextual fear memory in mice

Charlier

Tirelli

2011

Neuroscience

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Abstract-Albeit there is no doubt that histamine and its H 3 receptors participate in several aspects of learning and memory, such as memory consolidation, nothing is known about their potential involvement in memory reconsolidation. On the basis of previous reports of pro-cognitive effects of histamine H 3 receptor inverse agonists (which augment histamine release), we investigated to what extent the most representative of them, thioperamide, is able to facilitate reconsolidation of a contextually-conditioned fear memory in C57BL/6J mice. We also examined the effects of thioperamide on the stark disruptive effect that the non-competitive N-methyl-D-aspartate (NMDA) antagonist dizocilpine (MK-801) typically exerts on both reconsolidation and consolidation. Post-training systemic injections (i.p.) of thioperamide facilitated consolidation at 10 and 20 mg/kg and reversed amnesia induced by an i.p. injection of 0.12 mg/kg dizocilpine at 5, 10 and 20 mg/kg. Importantly, none of the five thioperamide doses (2.5, 5, 10, 20 and 30 mg/kg) given right after reactivation (reexposure to the context in which training took place 48 h earlier) affected reconsolidation, whereas all similarly given doses of dizocilpine (0.03, 0.06 and 0.12 mg/kg) disrupted it more or less equally. By contrast, thioperamide was able to unambiguously reverse the deficit in reconsolidation induced by 0.12 mg/kg dizocilpine at 10 and 20, but not 5 mg/kg. This is the first demonstration of an involvement of the interactive articulation between histamine and NMDA receptors in the mechanisms of memory reconsolidation, which seems to be indifferent to an increase of brain histamine per se. The results suggest a qualitatively different participation of histaminergic signalling in the mechanisms of reconsolidation and consolidation. The precise circuits within which these interactions take place are yet to be identified.

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“…There is evidence that activation of the H 3 R may be implicated in neuroprotection as H 3 R mRNA is up‐regulated following induction of cerebral ischemia (Lozada et al. 2005) or kainic acid induced seizures in the rat (Lintunen et al.…”

Section: Discussionmentioning

confidence: 99%

Activation of the histaminergic H₃ receptor induces phosphorylation of the Akt/GSK‐3β pathway in cultured cortical neurons and protects against neurotoxic insults

Mariottini

Scartabelli

Bongers

et al. 2009

Journal of Neurochemistry

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Stimulation of histamine H 3 receptors (H 3 R) activates G i/oproteins that inhibit adenylyl cyclase and triggers MAPK and phospholipase A 2 . In a previous study, we showed that H 3 Rmediated phosphorylation of Akt at Ser473 occurs in primary cultures of rat cortical neurons, but neither the downstream targets nor the function of such activation were explored. In this report we address these questions. Western blotting experiments showed that H 3 R-mediated activation of Akt in cultured rat cortical neurons was inhibited by LY 294004 and U0126, suggesting that it depends on phosphoinositide-3-kinase and mitogen-activated protein kinase kinase. H 3 R activation phosphorylated, hence inactivated, the Akt downstream effector glycogen synthase kinase-3b, increased the expression of the antiapoptotic protein Bcl-2 and protected cultured rat and mouse cortical neurons from neurotoxic insults in a dose-dependent manner. All these effects were inhibited by the H 3 R antagonist inverse/agonist thioperamide. Mouse cortical cells expressed H 3 R as revealed by immunostaining experiments, and stimulation of H 3 R phoshorylated Akt and decreased caspase 3 activity. Hence, we uncovered a yet unexplored action of the H 3 R that may help understand the impact of H 3 R signaling in the CNS.

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Postischemic regulation of central histamine receptors

Cited by 30 publications

References 50 publications

Protective Effect of Carnosine on Subcortical Ischemic Vascular Dementia in Mice

Protective Effect of Carnosine on Subcortical Ischemic Vascular Dementia in Mice

Differential effects of histamine H3 receptor inverse agonist thioperamide, given alone or in combination with the N-methyl-d-aspartate receptor antagonist dizocilpine, on reconsolidation and consolidation of a contextual fear memory in mice

Activation of the histaminergic H₃ receptor induces phosphorylation of the Akt/GSK‐3β pathway in cultured cortical neurons and protects against neurotoxic insults

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Postischemic regulation of central histamine receptors

Cited by 30 publications

References 50 publications

Protective Effect of Carnosine on Subcortical Ischemic Vascular Dementia in Mice

Protective Effect of Carnosine on Subcortical Ischemic Vascular Dementia in Mice

Differential effects of histamine H3 receptor inverse agonist thioperamide, given alone or in combination with the N-methyl-d-aspartate receptor antagonist dizocilpine, on reconsolidation and consolidation of a contextual fear memory in mice

Activation of the histaminergic H3 receptor induces phosphorylation of the Akt/GSK‐3β pathway in cultured cortical neurons and protects against neurotoxic insults

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Product

Resources

About

Activation of the histaminergic H₃ receptor induces phosphorylation of the Akt/GSK‐3β pathway in cultured cortical neurons and protects against neurotoxic insults