Postmenopausal Breast Cancer in Women, Clinical and Epidemiological Factors Related to the Molecular Subtype: A Retrospective Cohort Study in a Single Institution for 13 Years. Follow-Up Data

Abstract

This study focused on the characteristics of postmenopausal breast cancer in the population of southeastern Europe. This retrospective study explored the clinical, epidemiological, and molecular characteristics of women with postmenopausal breast cancer. Material and methods: A retrospective cohort study was performed on 721 postmenopausal breast cancer patients selected from the database of our institution. The data collected consisted of age, living environment, location of the breast tumor, stage of the disease, and molecular sub-type. Patient characteristics were collected based on a systematic chart audit from medical records. The data were analyzed using SPSS 20.0 and Pearson analysis. Results: The most frequent age range for breast cancer diagnosis was 51 to 70 years old. Most of the patients (80.7%) came from an urban environment. The vast majority of patients were initially diagnosed in stage II (40.3%) and III (30.3%). The most frequent molecular sub-types were luminal B (39%) and luminal A (35.4%). Almost half of the breast tumors were located in the upper outer quadrant (48.8%). Conclusions: The results of this study describe the profile of patients in southeastern Europe within our institution diagnosed with postmenopausal breast cancer. In our study, patients were first diagnosed with more advanced stages of breast cancer compared with other European countries.

The Benefits of Physical Activity to Reduce Mortality in Postmenopausal Breast Cancer Patients: A Literature Review

“…These results are similar to other studies [56][57][58]. In addition, a cohort study also stated that in the middle age group (41-50 and 51-60 years) of postmenopausal women, the Luminal B subtype (ER+, PR+/-, HER2-, Ki-67 14-30%) is the most diagnosed breast cancer in this group, while for the age group (61-70 and 71-80 years) most of the patients had the Luminal A subtype (ER+, PR+, HER2-, Ki-67 < 14%) [59]. It can be caused by the increase in fat tissue in the body, especially in postmenopausal women, causing an increase in the secretion of the hormone estrogen which results in an increased risk of invasive breast cancer with positive ER subtype [60][61][62].…”

Pregnancy Reduces Il33+ Hybrid Progenitor Accumulation in the Aged Mammary Gland

“…However, our study suggests that basal cells can acquire hybrid features with aging by turning on pathways active in luminal cells during early pubertal development. In support of this model, studies have shown that basal cells can acquire hybrid phenotypes upon transformation 57 and form luminal-like tumors 52,54 , which are the predominant subtypes found in postmenopausal breast cancers 58 . Future work will determine the precise contribution of basal cells to tumor initiation with aging.…”

Skin-Reducing Mastectomy and Immediate Reconstruction for a Large Recurrent Borderline Phyllodes Tumor

“…There are no prospective randomized data supporting the use of radiation treatment with phyllodes tumors. However, in the setting where additional recurrence would create significant morbidity (e.g., chest wall recurrence following mastectomy), radiotherapy may be considered following the same principles, which are applied to the treatment of soft tissue sarcoma [35][36][37].…”