Postmenopausal Canarian women receiving oral glucocorticoids have an increased prevalence of vertebral fractures and low values of bone mineral density measured by quantitative computer tomography and dual X-ray absorptiometry, without significant changes in parathyroid hormone

Sosa, Manuel; Saavedra, Pedro; Navarro, Marlene Isabel Hernández; Tejada, Marı́a Jesús Gómez de; Martin, Audrey; Peña, Pilar de la; Gómez, J Quesada

doi:10.1016/j.ejim.2007.08.005

Cited by 10 publications

(10 citation statements)

References 31 publications

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“…Glucocorticoids, widely used for inflammatory and autoimmune disease treatment, affect both directly and indirectly the bone cell activity leading to a bone mass reduction that occurs, independently of sex and age, in 30–50% of treated patients [64,65,66]. Several studies have demonstrated that a chronic glucocorticoid therapy is strongly associated with a low bone mineral density (BMD) and a high susceptibility of fractures [68,69,70,71]. Sosa et al and Migliaccio et al demonstrated that prednisolone treatment induces apoptosis of osteoblasts and osteocytes that leads to the reduction of bone formation [70,71].…”

Section: Endocannabinoid/endovanilloid System In Osteoporosismentioning

confidence: 99%

“…Several studies have demonstrated that a chronic glucocorticoid therapy is strongly associated with a low bone mineral density (BMD) and a high susceptibility of fractures [68,69,70,71]. Sosa et al and Migliaccio et al demonstrated that prednisolone treatment induces apoptosis of osteoblasts and osteocytes that leads to the reduction of bone formation [70,71].…”

Section: Endocannabinoid/endovanilloid System In Osteoporosismentioning

confidence: 99%

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The Endocannabinoid/Endovanilloid System in Bone: From Osteoporosis to Osteosarcoma

Rossi

Tortora

Punzo

et al. 2019

IJMS

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Bone is a dynamic tissue, whose homeostasis is maintained by a fine balance between osteoclast (OC) and osteoblast (OB) activity. The endocannabinoid/endovanilloid (EC/EV) system’s receptors are the cannabinoid receptor type 1 (CB1), the cannabinoid receptor type 2 (CB2), and the transient receptor potential cation channel subfamily V member 1 (TRPV1). Their stimulation modulates bone formation and bone resorption. Bone diseases are very common worldwide. Osteoporosis is the principal cause of bone loss and it can be caused by several factors such as postmenopausal estrogen decrease, glucocorticoid (GC) treatments, iron overload, and chemotherapies. Studies have demonstrated that CB1 and TRPV1 stimulation exerts osteoclastogenic effects, whereas CB2 stimulation has an anti-osteoclastogenic role. Moreover, the EC/EV system has been demonstrated to have a role in cancer, favoring apoptosis and inhibiting cell proliferation. In particular, in bone cancer, the modulation of the EC/EV system not only reduces cell growth and enhances apoptosis but it also reduces cell invasion and bone pain in mouse models. Therefore, EC/EV receptors may be a useful pharmacological target in the prevention and treatment of bone diseases. More studies to better investigate the biochemical mechanisms underlining the EC/EV system effects in bone are needed, but the synthesis of hybrid molecules, targeting these receptors and capable of oppositely regulating bone homeostasis, seems to be a promising and encouraging prospective in bone disease management.

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Section: Endocannabinoid/endovanilloid System In Osteoporosismentioning

confidence: 99%

Section: Endocannabinoid/endovanilloid System In Osteoporosismentioning

confidence: 99%

The Endocannabinoid/Endovanilloid System in Bone: From Osteoporosis to Osteosarcoma

Rossi

Tortora

Punzo

et al. 2019

IJMS

View full text Add to dashboard Cite

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“…It is well known that the standard reference model for the measurement of vitamin D is high pressure liquid chromatography (HPLC) 27 , to which we did not have access in our Unit. Another limitation is that of having carried out only a descriptive study without using a control group with which to compare the results, but it should be taken into account that the levels set for the establishment of insufficiency and deficiency are already, practically speaking, a matter of consensus (30 ng/ml and 20 ng/ml of 25HCC, respectively) [11][12][13][14][15]17,20 as well as the upper limit of PTH, which has been established as normal at 88 ng/ml in our laboratory through other studies [28][29][30][31] . On the other hand, one of the strengths of the study is its sample size, 104 patients with spinal injury, the highest number found in the literature which we have been able to consult on this matter.…”

Section: Discussionmentioning

confidence: 99%

Prevalencia de hipovitaminosis D e hiperparatiroidismo secundario en la Unidad de Lesionados Medulares de Gran Canaria: estudio preliminar

Gonzalez

Suárez

Calderín

et al. 2013

Rev Osteoporos Metab Miner

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Background: vitamin D deficiency is very common, and has been demonstrated in multiple studies in both the general population and in patients with different pathologies. However, it has been little studied in patients affected by spinal injury. Objective: to study the prevalence of hypovitaminosis D and the possible development of secondary hyperparathyroidism in a population of patients with spinal injury. Material and method: transverse descriptive study carried out in 104 patients affected by spinal injury. A clinical history was taken, a detailed physical examination carried out and a blood sample while fasting taken, with the least possible compression, from all patients. The analytical parameters were analysed using automated techniques and the determination of 25-hydroxyvitamin D (25HCC) and parathyroid hormone (PTH) was performed using electroimmunochemiluminescence (ECLIA). Results: the global mean value of 25-hydroxyvitamin D was 20.1 ± 11.6 n/ml. 84.6% of the patients had blood values of 25-hydroxyvitamin D lower than 30 ng/ml and 62% of all patients showed values lower than 20 ng/ml. The prevalence of vitamin D deficiency was similar in men and women. However, although we found an inverse correlation between levels of PTH and hydroxyvitamin D, only 5.8% of patients ended up developing secondary hyperparathyroidism. Conclusions: there is a high prevalence of hypovitaminosis D in patients with spinal injury. It is advisable, therefore, to include a study of this metabolite in the care protocol of these patients to correct these deficiencies as and when they are found.

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“…Previously DXA and QUS have been described as good predictors of the risk of suffering a vertebral fracture [7,8,18], and patients who sustained a vertebral fracture showed lower values of both DXA and QUS measurements [7,[19][20][21]. Nevertheless, the place of QUS in the management of metabolic bone diseases is less clear because DXA is still the gold standard for the diagnosis of osteoporosis.…”

Section: Discussionmentioning

confidence: 99%

Discriminative Ability of Heel Quantitative Ultrasound in Postmenopausal Women with Prevalent Vertebral Fractures: Application of Optimal Threshold Cutoff Values Using Classification and Regression Tree Models

et al. 2012

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Quantitative ultrasound (QUS) of the heel has been proposed as a screening tool to evaluate the bone status and risk of osteoporotic fragility fractures. The aim of this study was to define threshold values that would maximize the predictive ability of QUS to discriminate subjects with vertebral fractures using the classification and regression trees (CART) models. A cross-sectional analysis was made of a cohort of 1,132 postmenopausal women with a mean age of 58 years. A total of 205 women (18.1 %) presented with a history of vertebral fracture. For all patients, a questionnaire of osteoporosis risk factors was given and measurements of the heel QUS and bone mineral density at the lumbar spine and the proximal femur, obtained by dual-energy X-ray absorptiometry (DXA), were made. Spinal radiographs were assessed for vertebral fractures. Sensitivity, specificity, predictive values, likelihood ratios, and receiver operator characteristics (ROC) curve QUS values were calculated using the optimal threshold identified in the CART models. Cutoff values calculated from best CART model (i.e., a QUS index >90.5 %) yielded a sensitivity of 80.3 % (95 % CI 69.2-88.1), a negative predictive value of 94 % (95 % CI 90.1-96.5), and a specificity of 68.8 % (95 % CI 63.3-73.8). This cutoff value would obviate the need to perform DXA in 32.8 % of the women of our population at risk for vertebral fractures. The area under the ROC curve of the best model was 0.8071. QUS was shown to discriminate between women with and without a history of vertebral fracture and constitutes a useful tool for assessing vertebral fracture risk. The application of decision trees (CART analyses) was helpful to define the optimal threshold QUS values.

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Postmenopausal Canarian women receiving oral glucocorticoids have an increased prevalence of vertebral fractures and low values of bone mineral density measured by quantitative computer tomography and dual X-ray absorptiometry, without significant changes in parathyroid hormone

Cited by 10 publications

References 31 publications

The Endocannabinoid/Endovanilloid System in Bone: From Osteoporosis to Osteosarcoma

The Endocannabinoid/Endovanilloid System in Bone: From Osteoporosis to Osteosarcoma

Prevalencia de hipovitaminosis D e hiperparatiroidismo secundario en la Unidad de Lesionados Medulares de Gran Canaria: estudio preliminar

Discriminative Ability of Heel Quantitative Ultrasound in Postmenopausal Women with Prevalent Vertebral Fractures: Application of Optimal Threshold Cutoff Values Using Classification and Regression Tree Models

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