Postmenopausal Hormone Replacement Therapy Use Decreases Oxidative Protein Damage

Telci, Ayşegül; Çakatay, Ufuk; Akhan, Süleyman Engin; Bilgin, Murat E.; Turfanda, Abdullah; Sıvas, Ahmet

doi:10.1159/000067718

Cited by 37 publications

(27 citation statements)

References 24 publications

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“…It is well known that estrogens, with the contribution of their phenolic structure, have a clearance effect on ROS in both lipophilic and hydrophilic subcellular structures. Estrogens show this effect by breaking free radical chain reactions composed of membrane oxidation processes which lead to the inhibition of lipid and protein oxidation (Telci et al 2002;Topcuoglu et al 2009) due to these reasons male rats were used in our study.…”

Section: Discussionmentioning

confidence: 99%

Comparison of oxidative stress biomarkers in renal tissues of d-galactose induced, naturally aged and young rats

et al. 2011

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Ageing of kidneys is a clinical health issue of the society. Age-related renal insufficiency has important implications due to impaired redox homeostasis. We examined protein, DNA and lipid oxidation biomarkers as well as protein-bound sialic acid (SA) in the kidney tissues of D-galactose induced ageing rats, naturally aged rats and their corresponding young control group. Intraperitoneal injection of D-galactose (60 mg/kg/day) for 6 weeks to young male Sprague-Dawley rats (20-week-old) was used to establish mimetic ageing model. In this study, we investigated the levels of protein carbonyl groups (PCO), various thiol fractions such as total thiol groups (T-SH), protein (P-SH) and non-protein thiol groups (NP-SH), lipid oxidation parameters such as lipid hydroperoxides (LHP) and malondialdehyde (MDA), SA and 8-hydroxy-2'deoxyguanosine (8-OHdG) parameters for comparison of naturally aged, induced aged and young rats. In D-galactose induced aged group, PCO, LHP, MDA, and 8-OHdG concentrations were significantly higher than young control group, whereas T-SH, P-SH levels were significantly lower than the young rats. In addition, NP-SH and SA concentrations were similar between the mimetic ageing and young control groups. In naturally ageing rats, PCO and MDA levels were significantly higher, whereas T-SH, P-SH, NP-SH concentrations were low compared to young controls. On the other hand, SA and 8-OHdG levels were not different between the naturally ageing group and the young control group. Our results demonstrated that the rats in the mimetic ageing group, have significant similarities with the naturally aged rats in terms of impaired redox homeostasis and can be used as a reliable animal model for renal ageing.

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Section: Discussionmentioning

confidence: 99%

Comparison of oxidative stress biomarkers in renal tissues of d-galactose induced, naturally aged and young rats

et al. 2011

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“…This cardioprotection afforded by estrogen may be associated with a relaxing of the coronary artery (Gilligan et al 1994), a reduction in neutrophil infiltration (Delyani et al 1996), the scavenging of free radicals (Telci et al 2002), an increase in the production of nitric oxide (Node et al 1997), and (or) the inhibition of TNF-α production (Squadrito et al 1997). However, it has recently been shown that estrogen treatment for 6 weeks exerted no benefit on infarct size or ventricular dysrhythmias induced by left coronary occlusion and reperfusion in ovariectomized rats (Mcnulty et al 2000).…”

Section: Discussionmentioning

confidence: 99%

Effect of estrogen replacement treatment on ischemic preconditioning in isolated rat hearts

Peng¹,

Yu²,

Deng³

et al. 2004

Can. J. Physiol. Pharmacol.

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In the present study, we tested the effects of long-term estrogen replacement treatment on myocardial ischemia-reperfusion injury and on the cardioprotection of ischemic preconditioning in isolated hearts from ovariectomized rats. Ovariectomized rats were treated with 17beta-estradiol (30 micro g/kg/d, s.c.) for 12 weeks. Isolated rat hearts were perfused in the Langendorff mode. Heart rate, coronary flow, left ventricular pressure and its first derivative (+/-LVdp/dtmax) were recorded. Fifteen-min global ischemia and 30-min reperfusion caused a significant decrease of cardiac mechanical function, which were not affected by ovariectomy or estrogen replacement treatment. The isolated hearts in all groups could be preconditioned, and the cardioprotection afforded by preconditioning in the sham-operated rats was greater compared with ovariectomized rats with or without estrogen treatment. These results suggest that long-term estrogen replacement treatment exerts no effect on the inhibition of mechanical function after ischemia-reperfusion, and this study also suggests that estrogen does not affect ischemic preconditioning in isolated hearts of ovariectomized rats.

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“…Apparently both types of treatment did not significantly affect systemic oxidative stress in vivo. Telci and colleagues examined the influence of HRT on OxS [130] in 12 postmenopausal women who had received HRT for 6 months, and 13 postmenopausal women who did not receive HRT, as the control group. They found that after the period of therapy, protein carbonyls (but not nitrotyrosine) decreased.…”

Section: Hrt (And/or Ert) and Oxsmentioning

confidence: 99%

Oxidative damage and the pathogenesis of menopause related disturbances and diseases

Cervellati

Bergamini

2016

Clinical Chemistry and Laboratory Medicine (CCLM)

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Abstract:The postmenopausal phase of life is frequently associated in women with subjective symptoms (e.g. vasomotor) and real diseases (atherosclerosis with coronary ischemia, osteoporosis, Alzheimer-type neurodegeneration, urogenital dystrophy), which together determine the post-menopausal syndrome. Observations that oxidative damage by reactive oxygen/nitrogen species in experimental models can contribute to the pathogenesis of these disturbances stimulated research on the relationships between menopause, its endocrine deficiency, oxidative balance and the "wellness" in postmenopausal life. The connection among these events is probably due to the loss of protective actions exerted by estrogens during the fertile life. Most recent studies have revealed that estrogens exert an antioxidant action not by direct chemical neutralization of reactants as it was expected until recently but by modulating the expression of antioxidant enzymes that control levels of biological reducing agents. Also nutritional antioxidants apparently act by a similar mechanism. From this perspective it is conceivable that a cumulative control of body oxidant challenges and biological defenses could help in monitoring between "normal" and "pathological" menopause. However, as clinical studies failed to confirm this scenario in vivo, we have decided to review the existing literature to understand the causes of this discrepancy and whether this was due to methodologic reasons or to real failure of the basic hypothesis.

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Postmenopausal Hormone Replacement Therapy Use Decreases Oxidative Protein Damage

Cited by 37 publications

References 24 publications

Comparison of oxidative stress biomarkers in renal tissues of d-galactose induced, naturally aged and young rats

Comparison of oxidative stress biomarkers in renal tissues of d-galactose induced, naturally aged and young rats

Effect of estrogen replacement treatment on ischemic preconditioning in isolated rat hearts

Oxidative damage and the pathogenesis of menopause related disturbances and diseases

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